Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury
The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels. In the present study, muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury...
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| Veröffentlicht in: | Neural regeneration research 2010-09, Vol.5 (18), p.1418-1422 |
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| container_title | Neural regeneration research |
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| creator | Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu |
| description | The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels. In the present study, muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats. There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury, but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury （P 〈 0.01）. At day 30 after facial nerve injury, 50 pmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid, and the change range was 82% of artificial cerebrospinal fluid （P 〈 0.05）. These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release, and that the transmembrane flow of calcium ions is also involved in this process. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2010.18.010 |
| format | Article |
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In the present study, muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats. There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury, but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury （P 〈 0.01）. At day 30 after facial nerve injury, 50 pmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid, and the change range was 82% of artificial cerebrospinal fluid （P 〈 0.05）. These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release, and that the transmembrane flow of calcium ions is also involved in this process.</description><identifier>ISSN: 1673-5374</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2010.18.010</identifier><language>eng</language><publisher>Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Oncology,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Science and Education,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%School of Public Health,Shandong University,Jinan 250012,Shandong Province,China%Department of Otolaryngology-Head and Neck Surgery,Union Hospital of Huazhong University of Science and Technology,Wuhan430022,Hubei Province,China</publisher><subject>受体介导 ; 毒蕈碱受体 ; 激光共聚焦显微镜 ; 神经损伤 ; 细胞内游离钙 ; 面神经核</subject><ispartof>Neural regeneration research, 2010-09, Vol.5 (18), p.1418-1422</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu</creatorcontrib><title>Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels. In the present study, muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats. There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury, but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury （P 〈 0.01）. At day 30 after facial nerve injury, 50 pmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid, and the change range was 82% of artificial cerebrospinal fluid （P 〈 0.05）. These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release, and that the transmembrane flow of calcium ions is also involved in this process.</description><subject>受体介导</subject><subject>毒蕈碱受体</subject><subject>激光共聚焦显微镜</subject><subject>神经损伤</subject><subject>细胞内游离钙</subject><subject>面神经核</subject><issn>1673-5374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNo9kEFPwzAMhXMAiTH4DxHihlrapGnTI5qAIQ1xgQuXynXdLaVLIWlB268n0xAXP8n-5Pdsxq7TJJZlXt52sfHexmleyEjJIotFEkapjoOcsNl__4yde98lidKlkDP2_jx5BGesQe4I6XMcXLSlxsBIDUfo0Uxbjhuwa_LcWA7cwci3Q0M9H1reAhrouSX3TdxO2NN0wLrJ7S7YaQu9p8s_nbO3h_vXxTJavTw-Le5WEYpUjxGS0hJrkVOthRKqSQooVNtIzGssdJYRSCFEI8sinFJTjY2GPBWQScQMCjlnN8e9P2DbkLPqhsnZ4Fjt177b-11X0eEZqQ4l0FdHGjeDXX-ZwNeAH63pqZJKHUxS-Qv0BGVY</recordid><startdate>20100930</startdate><enddate>20100930</enddate><creator>Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu</creator><general>Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Oncology,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Science and Education,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%School of Public Health,Shandong University,Jinan 250012,Shandong Province,China%Department of Otolaryngology-Head and Neck Surgery,Union Hospital of Huazhong University of Science and Technology,Wuhan430022,Hubei Province,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20100930</creationdate><title>Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury</title><author>Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c218t-ce583cb26eb82525d07a75fd3c6bc7844ea3222d397010bebcd8a612a43cc4a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>受体介导</topic><topic>毒蕈碱受体</topic><topic>激光共聚焦显微镜</topic><topic>神经损伤</topic><topic>细胞内游离钙</topic><topic>面神经核</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2010-09-30</date><risdate>2010</risdate><volume>5</volume><issue>18</issue><spage>1418</spage><epage>1422</epage><pages>1418-1422</pages><issn>1673-5374</issn><abstract>The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels. In the present study, muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats. There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury, but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury （P 〈 0.01）. At day 30 after facial nerve injury, 50 pmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid, and the change range was 82% of artificial cerebrospinal fluid （P 〈 0.05）. These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release, and that the transmembrane flow of calcium ions is also involved in this process.</abstract><pub>Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Oncology,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%Department of Science and Education,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China%School of Public Health,Shandong University,Jinan 250012,Shandong Province,China%Department of Otolaryngology-Head and Neck Surgery,Union Hospital of Huazhong University of Science and Technology,Wuhan430022,Hubei Province,China</pub><doi>10.3969/j.issn.1673-5374.2010.18.010</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neural regeneration research, 2010-09, Vol.5 (18), p.1418-1422 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | 受体介导 毒蕈碱受体 激光共聚焦显微镜 神经损伤 细胞内游离钙 面神经核 |
| title | Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury |
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