Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells

Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat hear...

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Veröffentlicht in:	Cellular & molecular immunology 2007-04, Vol.4 (2), p.127-133
Hauptverfasser:	Okruhlicova, Ludmila, Morwinski, Rosemarie, Schulze, Wolfgang, Bartel, Sabine, Weismann, Peter, Tribulova, Narcisa, Wallukat, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Adult Angiotensin II - pharmacology Animals Animals, Newborn Autoantibodies - blood Cell Degranulation Cell Differentiation Cells, Cultured Female G-蛋白耦合受体 Humans Hypertension - immunology Hypertension, Pulmonary - immunology Male Mast Cells - drug effects Mast Cells - metabolism Mast Cells - ultrastructure Middle Aged Myocardium - metabolism Myocardium - ultrastructure Phenylephrine - pharmacology Pre-Eclampsia - immunology Pregnancy Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - immunology Receptors, Adrenergic, alpha-1 - immunology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - immunology Receptors, G-Protein-Coupled - metabolism Time Factors 心肌细胞肥大细胞自身抗体
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