Gene Transfer to Dendritic Cells Induced a Protective Immunity against Melanoma

Lentiviral vectors have shown promises for efficient gene transfer to dividing as well as nondividing cells. In this study, we explored lentiviral vector-mediated, the entire mTRP-2 gene transfer and expression in dendritic cells （DCs）. Adoptive transfer of DCs-expressing mTRP-2 （DC-HR＇CmT2） into C5...

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Veröffentlicht in:	Cellular & molecular immunology 2005-08, Vol.2 (4), p.281-288
Hauptverfasser:	Metharom, Pat, Ellem, Kay A O, Wei, Ming Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Cancer Vaccines Dendritic Cells - immunology Dendritic Cells - metabolism Female Genetic Vectors Lentivirus Lymphocyte Culture Test, Mixed Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Peptides - immunology Peptides - metabolism Transduction, Genetic TRPC Cation Channels - chemistry TRPC Cation Channels - immunology TRPC Cation Channels - metabolism 保护作用免疫反应基因转化树状细胞黑色素瘤
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