Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy
Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer. Herein, we designed 1,7-diphenyl-substituted meso‑CF3-BDP monomer confirmed by X-ray crystallographic analysis. The low-barrier rotation of the –CF3 group in meso‑CF3...
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| Veröffentlicht in: | Chinese chemical letters 2023-09, Vol.34 (9), p.108223-206, Article 108223 |
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| creator | Ye, Chujing Zhang, Shan Zhang, Dongxiang Shen, Yue Wang, Zhan Wang, Huan Ren, Junyi Jiang, Xin-Dong Du, Jianjun Shang, Rong Wang, Guiling |
| description | Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer. Herein, we designed 1,7-diphenyl-substituted meso‑CF3-BDP monomer confirmed by X-ray crystallographic analysis. The low-barrier rotation of the –CF3 group in meso‑CF3-BDP 1 significantly enhances the non-radiative efficiency, and the photothermal conversion efficiency (PCE) of the self-assembled nanoparticles (1-NPs: λabs = 746 nm) by J-aggregates was 82%. 1-NPs could effectively block cell cycle progression, inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation (0.2 W/cm2). This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.
Meso-CF3-BODIPY nanoparticles by J-aggregates enhanced photothermal conversion efficiency through the insertion of rotating segment and triggered the cancer cells apoptosis in photothermal therapy at low power laser density.
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| doi_str_mv | 10.1016/j.cclet.2023.108223 |
| format | Article |
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Meso-CF3-BODIPY nanoparticles by J-aggregates enhanced photothermal conversion efficiency through the insertion of rotating segment and triggered the cancer cells apoptosis in photothermal therapy at low power laser density.
[Display omitted]</description><identifier>ISSN: 1001-8417</identifier><identifier>EISSN: 1878-5964</identifier><identifier>DOI: 10.1016/j.cclet.2023.108223</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Cell apoptosis ; CF3-BODIPY ; J-aggregate ; NIR dye ; Photothermal therapy</subject><ispartof>Chinese chemical letters, 2023-09, Vol.34 (9), p.108223-206, Article 108223</ispartof><rights>2023</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-cd14b0daf44efddd340d6b97ed66af8aa0ec8f97c8b444c776379167438766663</citedby><cites>FETCH-LOGICAL-c335t-cd14b0daf44efddd340d6b97ed66af8aa0ec8f97c8b444c776379167438766663</cites><orcidid>0000-0002-9780-1124 ; 0000-0002-6748-7349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zghxkb/zghxkb.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ye, Chujing</creatorcontrib><creatorcontrib>Zhang, Shan</creatorcontrib><creatorcontrib>Zhang, Dongxiang</creatorcontrib><creatorcontrib>Shen, Yue</creatorcontrib><creatorcontrib>Wang, Zhan</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Ren, Junyi</creatorcontrib><creatorcontrib>Jiang, Xin-Dong</creatorcontrib><creatorcontrib>Du, Jianjun</creatorcontrib><creatorcontrib>Shang, Rong</creatorcontrib><creatorcontrib>Wang, Guiling</creatorcontrib><title>Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy</title><title>Chinese chemical letters</title><description>Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer. Herein, we designed 1,7-diphenyl-substituted meso‑CF3-BDP monomer confirmed by X-ray crystallographic analysis. The low-barrier rotation of the –CF3 group in meso‑CF3-BDP 1 significantly enhances the non-radiative efficiency, and the photothermal conversion efficiency (PCE) of the self-assembled nanoparticles (1-NPs: λabs = 746 nm) by J-aggregates was 82%. 1-NPs could effectively block cell cycle progression, inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation (0.2 W/cm2). This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.
Meso-CF3-BODIPY nanoparticles by J-aggregates enhanced photothermal conversion efficiency through the insertion of rotating segment and triggered the cancer cells apoptosis in photothermal therapy at low power laser density.
[Display omitted]</description><subject>Cell apoptosis</subject><subject>CF3-BODIPY</subject><subject>J-aggregate</subject><subject>NIR dye</subject><subject>Photothermal therapy</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kLFuFDEQQFcRSAkJX5DGHZUPe-3Y3iIFHAlcFBGEoKCyvPbsno87e2U7IUfDr8ebo840MxrNm9G8pjmnZEEJFe83C2u3UBYtaVntqLZlR80JVVLhi07wV7UmhGLFqTxu3uS8IaRViomT5t9VGH0ASD6M6AabcUwwmgIZDTGhr6vv2Ad3b8GhHeSIl9cMf7z7tPr2CwUT4mRS8fVyRv0eGVv8Q0UdMlOcSsw-V8iuTfB5h3xA0zqWWNaQdmaL5mym_VnzejDbDG__59Pm5_XVj-UXfHv3ebX8cIstYxcFW0d5T5wZOIfBOcc4caLvJDghzKCMIWDV0Emres65lVIw2VEhOVNS1GCnzbvD3j8mDCaMehPvU6gX9d9x_fi7n82RjrTzJDtM2hRzTjDoKfmdSXtNiZ5t641-tq1nRh9sV-ryQEF94sFD0tl6CFWcT2CLdtG_yD8BuZuLAA</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Ye, Chujing</creator><creator>Zhang, Shan</creator><creator>Zhang, Dongxiang</creator><creator>Shen, Yue</creator><creator>Wang, Zhan</creator><creator>Wang, Huan</creator><creator>Ren, Junyi</creator><creator>Jiang, Xin-Dong</creator><creator>Du, Jianjun</creator><creator>Shang, Rong</creator><creator>Wang, Guiling</creator><general>Elsevier B.V</general><general>Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment,Shenyang University of Chemical Technology,Shenyang 110142,China%Department of Cell Biology,China Medical University,Shenyang 110122,China%State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 110624,China%Department of Chemistry,Graduate School of Science,Hiroshima University,Higashi-Hiroshima 7398526,Japan</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><orcidid>https://orcid.org/0000-0002-9780-1124</orcidid><orcidid>https://orcid.org/0000-0002-6748-7349</orcidid></search><sort><creationdate>20230901</creationdate><title>Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy</title><author>Ye, Chujing ; Zhang, Shan ; Zhang, Dongxiang ; Shen, Yue ; Wang, Zhan ; Wang, Huan ; Ren, Junyi ; Jiang, Xin-Dong ; Du, Jianjun ; Shang, Rong ; Wang, Guiling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-cd14b0daf44efddd340d6b97ed66af8aa0ec8f97c8b444c776379167438766663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell apoptosis</topic><topic>CF3-BODIPY</topic><topic>J-aggregate</topic><topic>NIR dye</topic><topic>Photothermal therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ye, Chujing</creatorcontrib><creatorcontrib>Zhang, Shan</creatorcontrib><creatorcontrib>Zhang, Dongxiang</creatorcontrib><creatorcontrib>Shen, Yue</creatorcontrib><creatorcontrib>Wang, Zhan</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Ren, Junyi</creatorcontrib><creatorcontrib>Jiang, Xin-Dong</creatorcontrib><creatorcontrib>Du, Jianjun</creatorcontrib><creatorcontrib>Shang, Rong</creatorcontrib><creatorcontrib>Wang, Guiling</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ye, Chujing</au><au>Zhang, Shan</au><au>Zhang, Dongxiang</au><au>Shen, Yue</au><au>Wang, Zhan</au><au>Wang, Huan</au><au>Ren, Junyi</au><au>Jiang, Xin-Dong</au><au>Du, Jianjun</au><au>Shang, Rong</au><au>Wang, Guiling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy</atitle><jtitle>Chinese chemical letters</jtitle><date>2023-09-01</date><risdate>2023</risdate><volume>34</volume><issue>9</issue><spage>108223</spage><epage>206</epage><pages>108223-206</pages><artnum>108223</artnum><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer. Herein, we designed 1,7-diphenyl-substituted meso‑CF3-BDP monomer confirmed by X-ray crystallographic analysis. The low-barrier rotation of the –CF3 group in meso‑CF3-BDP 1 significantly enhances the non-radiative efficiency, and the photothermal conversion efficiency (PCE) of the self-assembled nanoparticles (1-NPs: λabs = 746 nm) by J-aggregates was 82%. 1-NPs could effectively block cell cycle progression, inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation (0.2 W/cm2). This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.
Meso-CF3-BODIPY nanoparticles by J-aggregates enhanced photothermal conversion efficiency through the insertion of rotating segment and triggered the cancer cells apoptosis in photothermal therapy at low power laser density.
[Display omitted]</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cclet.2023.108223</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9780-1124</orcidid><orcidid>https://orcid.org/0000-0002-6748-7349</orcidid></addata></record> |
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| ispartof | Chinese chemical letters, 2023-09, Vol.34 (9), p.108223-206, Article 108223 |
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| source | Alma/SFX Local Collection |
| subjects | Cell apoptosis CF3-BODIPY J-aggregate NIR dye Photothermal therapy |
| title | Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy |
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