Organocatalytic enantioselective construction of bicyclic y-butrolactones

Organocatalytic enantioselective construction of bicyclic y-butrolactones

An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been es-tablished herein,which provides an efficient access to chiral bicyclic y-butyrolactones in good yields,enantioselectivities and diastereoselectivities.Further transformations of product are demonstrat...

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Veröffentlicht in:中国化学快报（英文版） 2023, Vol.34 (7), p.122-126
Hauptverfasser: Qiang Zhang, Jingxiang Pang, Tian-Zhang Wang, Feng Chen, Minghao Shen, Tianyu Li, Yongshuai Chai, Yu-Feng Liang, Jie Sun, Zhushuang Bai
Format: Artikel
Sprache:eng
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Zusammenfassung:An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been es-tablished herein,which provides an efficient access to chiral bicyclic y-butyrolactones in good yields,enantioselectivities and diastereoselectivities.Further transformations of product are demonstrated.A di-amine mediated catalytic cycle is proposed.
ISSN:1001-8417
DOI:10.1016/j.cclet.2022.108121