Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection
A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester bond as the recognition group were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with the smallest acetate group displayed t...
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| Veröffentlicht in: | Chinese chemical letters 2022-09, Vol.33 (9), p.4233-4237 |
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| creator | He, Shengui Zhang, Shufang Zhao, Xin Zhu, Xinyue Chen, Lisen Cui, Jingnan |
| description | A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester bond as the recognition group were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with the smallest acetate group displayed the highest activity toward AChE. The detection limit of NDRO-1 for sensing AChE was 0.32 µg/mL, and Km was 6.40 µmol/L, indicating ultra-sensitivity and good affinity of NDRO-1 toward AChE. NDRO-1 was used to detect the inhibitory of four kinds of pesticides including methamidophos, dichlorvos, and the detection limit was lower than 50 µg/L, which was further used in pesticide residues detection.
A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester groups as the recognition site were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with acetate group displayed highly selective and sensitive toward AChE and was further used to detect pesticide residues. [Display omitted] |
| doi_str_mv | 10.1016/j.cclet.2022.02.020 |
| format | Article |
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A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester groups as the recognition site were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with acetate group displayed highly selective and sensitive toward AChE and was further used to detect pesticide residues. [Display omitted]</description><identifier>ISSN: 1001-8417</identifier><identifier>EISSN: 1878-5964</identifier><identifier>DOI: 10.1016/j.cclet.2022.02.020</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Acetylcholinesterase ; Enzyme-activated ; NIR fluorescent probe ; Pesticide residue detection</subject><ispartof>Chinese chemical letters, 2022-09, Vol.33 (9), p.4233-4237</ispartof><rights>2022</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-71870ebcfdad0da8be1757eb29f11880d9420ce540a9a4aa42d897791c0a76f73</citedby><cites>FETCH-LOGICAL-c335t-71870ebcfdad0da8be1757eb29f11880d9420ce540a9a4aa42d897791c0a76f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zghxkb/zghxkb.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1001841722001346$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>He, Shengui</creatorcontrib><creatorcontrib>Zhang, Shufang</creatorcontrib><creatorcontrib>Zhao, Xin</creatorcontrib><creatorcontrib>Zhu, Xinyue</creatorcontrib><creatorcontrib>Chen, Lisen</creatorcontrib><creatorcontrib>Cui, Jingnan</creatorcontrib><title>Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection</title><title>Chinese chemical letters</title><description>A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester bond as the recognition group were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with the smallest acetate group displayed the highest activity toward AChE. The detection limit of NDRO-1 for sensing AChE was 0.32 µg/mL, and Km was 6.40 µmol/L, indicating ultra-sensitivity and good affinity of NDRO-1 toward AChE. NDRO-1 was used to detect the inhibitory of four kinds of pesticides including methamidophos, dichlorvos, and the detection limit was lower than 50 µg/L, which was further used in pesticide residues detection.
A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester groups as the recognition site were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with acetate group displayed highly selective and sensitive toward AChE and was further used to detect pesticide residues. [Display omitted]</description><subject>Acetylcholinesterase</subject><subject>Enzyme-activated</subject><subject>NIR fluorescent probe</subject><subject>Pesticide residue detection</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9UD1PwzAQjRBIlMIvYPHGlHJO0toZGFAFtFIFEoLZcuxL6xLsyHaB8utxKDPSSXfD-7j3suySwoQCnV1vJ0p1GCcFFMUEhoGjbEQ54_m0nlXH6QagOa8oO83OQtgCFJyXs1EWFma96fYkYIcqmg8kj8tn0nY75zEotJH03jVIWueJVBj3ndq4zlgMEb0MSKTVxMRAZN93RslonCXGkj4BjDIaSdIxeoeBaIyDhbPn2Ukru4AXf3ucvd7fvcwX-erpYTm_XeWqLKcxZ-l_wEa1WmrQkjdI2ZRhU9QtpZyDrqsCFE4rkLWspKwKzWvGaqpAslnLynF2ddD9lLaVdi22budtchTf683XWzO0BXXqLyHLA1J5F4LHVvTevEu_FxTE0LDYit-GxcARMAwk1s2BhSnEh0EvgjJoFWrjU1KhnfmX_wMtm4gf</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>He, Shengui</creator><creator>Zhang, Shufang</creator><creator>Zhao, Xin</creator><creator>Zhu, Xinyue</creator><creator>Chen, Lisen</creator><creator>Cui, Jingnan</creator><general>Elsevier B.V</general><general>State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20220901</creationdate><title>Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection</title><author>He, Shengui ; Zhang, Shufang ; Zhao, Xin ; Zhu, Xinyue ; Chen, Lisen ; Cui, Jingnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-71870ebcfdad0da8be1757eb29f11880d9420ce540a9a4aa42d897791c0a76f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetylcholinesterase</topic><topic>Enzyme-activated</topic><topic>NIR fluorescent probe</topic><topic>Pesticide residue detection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Shengui</creatorcontrib><creatorcontrib>Zhang, Shufang</creatorcontrib><creatorcontrib>Zhao, Xin</creatorcontrib><creatorcontrib>Zhu, Xinyue</creatorcontrib><creatorcontrib>Chen, Lisen</creatorcontrib><creatorcontrib>Cui, Jingnan</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Shengui</au><au>Zhang, Shufang</au><au>Zhao, Xin</au><au>Zhu, Xinyue</au><au>Chen, Lisen</au><au>Cui, Jingnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection</atitle><jtitle>Chinese chemical letters</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>33</volume><issue>9</issue><spage>4233</spage><epage>4237</epage><pages>4233-4237</pages><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester bond as the recognition group were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with the smallest acetate group displayed the highest activity toward AChE. The detection limit of NDRO-1 for sensing AChE was 0.32 µg/mL, and Km was 6.40 µmol/L, indicating ultra-sensitivity and good affinity of NDRO-1 toward AChE. NDRO-1 was used to detect the inhibitory of four kinds of pesticides including methamidophos, dichlorvos, and the detection limit was lower than 50 µg/L, which was further used in pesticide residues detection.
A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼8) derived from fluorophore NDRH with different volumes of ester groups as the recognition site were designed and synthesized for the detection of acetylcholinesterase (AChE), among which NDRO-1 with acetate group displayed highly selective and sensitive toward AChE and was further used to detect pesticide residues. [Display omitted]</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cclet.2022.02.020</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Chinese chemical letters, 2022-09, Vol.33 (9), p.4233-4237 |
| issn | 1001-8417 1878-5964 |
| language | eng |
| recordid | cdi_wanfang_journals_zghxkb202209016 |
| source | Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Acetylcholinesterase Enzyme-activated NIR fluorescent probe Pesticide residue detection |
| title | Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection |
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