Second-generation DNA-encoded multiple display on a constant macrocyclic scaffold enabled by an orthogonal protecting group strategy

DNA-encoded chemical library (DEL) represents an emerging drug discovery technology to construct compound libraries with abundant chemical combinations. While drug-like small molecule DELs facilitate the discovery of binders against targets with defined pockets, macrocyclic DELs harboring extended s...

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Veröffentlicht in:	Chinese chemical letters 2022-05, Vol.33 (5), p.2559-2563
Hauptverfasser:	Nie, Qigui, Zhong, Shuting, Li, Yangfeng, Zhang, Gong, Li, Yizhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical probe DNA-compatible DNA-encoded library Macrocyclic scaffold Protein–protein interaction
Online-Zugang:	Volltext
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