Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma
Arnequinol A (1), featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge, together with arnequinone A (2) bearing a highly conjugated methyl-shifting benzogeijerene skeleton, were isolated from Arnebia euchroma. Their structures were elucidated by extensive spe...
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| Veröffentlicht in: | Chinese chemical letters 2022-05, Vol.33 (5), p.2555-2558 |
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| container_title | Chinese chemical letters |
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| creator | Yan, Hai-Wei Du, Rong-Rong Zhang, Xu Yang, Ya-Nan Yuan, Xiang Feng, Zi-Ming Jiang, Jian-Shuang Zhang, Pei-Cheng |
| description | Arnequinol A (1), featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge, together with arnequinone A (2) bearing a highly conjugated methyl-shifting benzogeijerene skeleton, were isolated from Arnebia euchroma. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of the 13C nuclear magnetic resonance (NMR) data and electronic circular dichroism (ECD) spectra. The plausible biosynthetic pathways for 1 and 2 were presented. In in vitro test, compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10 µmol/L.
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| doi_str_mv | 10.1016/j.cclet.2021.09.064 |
| format | Article |
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[Display omitted] .</description><subject>Arnebia euchroma</subject><subject>Arnequinol A and arnequinone A</subject><subject>Cytotoxicity</subject><subject>Meroterpenoids</subject><subject>Neuroprotective activity</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMlOwzAQhi0EEqXwBFx840KClzh1Dhyiik2q1AucLdcZtw6t3ToJ29PjUrhyGM2i_5_RfAhdUpJTQsubNjdmDX3OCKM5qXJSFkdoROVEZqIqi-NUE0IzWdDJKTrrupYQJiUvR2heRw-7wfmwxjXWvsH6b-AB19e4fw948G43AN5ADD3ELfjgmg7bGDZ4b184jWEwq9Trc3Ri9bqDi988Ri_3d8_Tx2w2f3ia1rPMcC76TJoGJNMCQFhmmxRMUA0N54XVklhWgJCUCgZcMDEx1EpZVrqghV1ITikfo6vD3nftrfZL1YYh-nRRfS1XH6-LRIIRQQRPSn5Qmhi6LoJV2-g2On4qStSenmrVDz21p6dIpRK95Lo9uCA98eYgqs448AYaF8H0qgnuX_839ft5kA</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Yan, Hai-Wei</creator><creator>Du, Rong-Rong</creator><creator>Zhang, Xu</creator><creator>Yang, Ya-Nan</creator><creator>Yuan, Xiang</creator><creator>Feng, Zi-Ming</creator><creator>Jiang, Jian-Shuang</creator><creator>Zhang, Pei-Cheng</creator><general>Elsevier B.V</general><general>State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20220501</creationdate><title>Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma</title><author>Yan, Hai-Wei ; Du, Rong-Rong ; Zhang, Xu ; Yang, Ya-Nan ; Yuan, Xiang ; Feng, Zi-Ming ; Jiang, Jian-Shuang ; Zhang, Pei-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-8cde82a5ee5f2fdf2f251aed334fa80f24e581152e35257c1f8869a414fb83113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arnebia euchroma</topic><topic>Arnequinol A and arnequinone A</topic><topic>Cytotoxicity</topic><topic>Meroterpenoids</topic><topic>Neuroprotective activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Hai-Wei</creatorcontrib><creatorcontrib>Du, Rong-Rong</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Yang, Ya-Nan</creatorcontrib><creatorcontrib>Yuan, Xiang</creatorcontrib><creatorcontrib>Feng, Zi-Ming</creatorcontrib><creatorcontrib>Jiang, Jian-Shuang</creatorcontrib><creatorcontrib>Zhang, Pei-Cheng</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Hai-Wei</au><au>Du, Rong-Rong</au><au>Zhang, Xu</au><au>Yang, Ya-Nan</au><au>Yuan, Xiang</au><au>Feng, Zi-Ming</au><au>Jiang, Jian-Shuang</au><au>Zhang, Pei-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma</atitle><jtitle>Chinese chemical letters</jtitle><date>2022-05-01</date><risdate>2022</risdate><volume>33</volume><issue>5</issue><spage>2555</spage><epage>2558</epage><pages>2555-2558</pages><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>Arnequinol A (1), featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge, together with arnequinone A (2) bearing a highly conjugated methyl-shifting benzogeijerene skeleton, were isolated from Arnebia euchroma. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of the 13C nuclear magnetic resonance (NMR) data and electronic circular dichroism (ECD) spectra. The plausible biosynthetic pathways for 1 and 2 were presented. In in vitro test, compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10 µmol/L.
[Display omitted] .</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cclet.2021.09.064</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1001-8417 |
| ispartof | Chinese chemical letters, 2022-05, Vol.33 (5), p.2555-2558 |
| issn | 1001-8417 1878-5964 |
| language | eng |
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| source | Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Arnebia euchroma Arnequinol A and arnequinone A Cytotoxicity Meroterpenoids Neuroprotective activity |
| title | Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma |
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