The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism

The substrate resists the electrophilic attack of the bound dioxygen by the trim of its phenyl ring. [Display omitted] 4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for both drug and pesticide discovery. As a typical Fe(II)-dependent dioxygenase, HPPD catalyzes the complicated tr...

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Veröffentlicht in:	Chinese chemical letters 2021-06, Vol.32 (6), p.1920-1924
Hauptverfasser:	Wang, Xiaoning, Lin, Hongyan, Liu, Junjun, Zhao, Xinyun, Chen, Xi, Yang, Wenchao, Yang, Guangfu, Zhan, Chang-guo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxyphenylpyruvate dioxygenase Potential surface scan QM/MM calculation Substrate self-inhibition
Online-Zugang:	Volltext
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