Radiosensitization of human pancreatic cancer by piperlongumine analogues

A series of piperlongumine derivatives were synthesized. Compounds 9c and 9d enhanced the radiosensitivity of Panc-1 and SW1990 cells with high sensitivity enhancement ratios. They also significantly inhibited tumor growth in pancreatic bi-flank xenograft tumor model. They can induce ROS expression...

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Veröffentlicht in:	Chinese chemical letters 2021-03, Vol.32 (3), p.1197-1201
Hauptverfasser:	Ma, Hao, Wu, Yuelin, Zhang, Wannian, Zhang, Huojun, Miao, Zhenyuan, Zhuang, Chunlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bi-flank xenograft tumor model Keap1-Nrf2 Pancreatic cancer Piperlongumine Radiosensitization Reactive oxygen species (ROS) Sensitivity enhancement ratio (SER)
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