Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy
The dual anticancer drugs-conjugated PDOXCBs nanoparticles were facilely prepared by aqueous precipitation copolymerization of two dopamine prodrugs, which integrated intrinsic photothermia of PDA with the polyprodrug-induced cocktail chemotherapy for potentialcombination cancer PTT−CCTapplication....
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| Veröffentlicht in: | Chinese chemical letters 2021-01, Vol.32 (1), p.561-564 |
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| creator | Zhou, Lei Du, Chang Zhang, Rong Dong, Changming |
| description | The dual anticancer drugs-conjugated PDOXCBs nanoparticles were facilely prepared by aqueous precipitation copolymerization of two dopamine prodrugs, which integrated intrinsic photothermia of PDA with the polyprodrug-induced cocktail chemotherapy for potentialcombination cancer PTT−CCTapplication.
[Display omitted]
We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L d,l-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT−CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro. |
| doi_str_mv | 10.1016/j.cclet.2020.02.043 |
| format | Article |
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[Display omitted]
We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L d,l-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT−CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro.</description><identifier>ISSN: 1001-8417</identifier><identifier>EISSN: 1878-5964</identifier><identifier>DOI: 10.1016/j.cclet.2020.02.043</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Cocktail chemotherapy ; Combination therapy ; Near infrared ; Photothermal therapy ; Polymer drug conjugate</subject><ispartof>Chinese chemical letters, 2021-01, Vol.32 (1), p.561-564</ispartof><rights>2021</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-7aea9772c5511b07ea7e703a899450057c3e2154cffac982b3f37a54f0b7662d3</citedby><cites>FETCH-LOGICAL-c335t-7aea9772c5511b07ea7e703a899450057c3e2154cffac982b3f37a54f0b7662d3</cites><orcidid>0000-0002-7540-1082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zghxkb/zghxkb.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1001841720301030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Du, Chang</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Dong, Changming</creatorcontrib><title>Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy</title><title>Chinese chemical letters</title><description>The dual anticancer drugs-conjugated PDOXCBs nanoparticles were facilely prepared by aqueous precipitation copolymerization of two dopamine prodrugs, which integrated intrinsic photothermia of PDA with the polyprodrug-induced cocktail chemotherapy for potentialcombination cancer PTT−CCTapplication.
[Display omitted]
We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L d,l-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT−CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro.</description><subject>Cocktail chemotherapy</subject><subject>Combination therapy</subject><subject>Near infrared</subject><subject>Photothermal therapy</subject><subject>Polymer drug conjugate</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1TAQhSMEEqXlCdh4xyrp2E7iZMECVfxUqsQCurYmzuRep4kd2U7h9ulxe1mzmtHROXM0X1F84FBx4O31XBmzUKoECKhAVFDLV8UF71RXNn1bv847AC-7mqu3xbsYZwDRdbK9KJ5-Jrvuiy0Dxc27aB-JjTsubAz7IZbGu3k_YKKRbX45jX7D1TpiDl1eQ7K5NrLJB5aOxIxfB-swWe_YdvTJZzGsuOQz5iGhXZg50vqi4na6Kt5MuER6_29eFvdfv_y6-V7e_fh2e_P5rjRSNqlUSNgrJUzTcD6AIlSkQGLX93UD0CgjSfCmNtOEpu_EICepsKknGFTbilFeFh_Pd3-jm9Ad9Oz34HKjfjoc_zwMGVqGyKHPTnl2muBjDDTpLdgVw0lz0M-g9axfQOtn0BqEzqBz6tM5RfmJR0tBR2PJGRptIJP06O1_838ByZqLjA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Zhou, Lei</creator><creator>Du, Chang</creator><creator>Zhang, Rong</creator><creator>Dong, Changming</creator><general>Elsevier B.V</general><general>School of Chemistry and Chemical Engineering,Shanghai Key Laboratory of Electrical Insulation and Thermal Aging,Shanghai Jiao Tong University,Shanghai 200240,China%School of Chemistry and Chemical Engineering,Shanghai Key Laboratory of Electrical Insulation and Thermal Aging,Shanghai Jiao Tong University,Shanghai 200240,China</general><general>Joint Research Center for Precision Medicine,Department of Obstetrics and Gynecology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus,Shanghai Fengxian Central Hospital,Shanghai 201499,China%Joint Research Center for Precision Medicine,Department of Obstetrics and Gynecology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus,Shanghai Fengxian Central Hospital,Shanghai 201499,China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><orcidid>https://orcid.org/0000-0002-7540-1082</orcidid></search><sort><creationdate>202101</creationdate><title>Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy</title><author>Zhou, Lei ; Du, Chang ; Zhang, Rong ; Dong, Changming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-7aea9772c5511b07ea7e703a899450057c3e2154cffac982b3f37a54f0b7662d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cocktail chemotherapy</topic><topic>Combination therapy</topic><topic>Near infrared</topic><topic>Photothermal therapy</topic><topic>Polymer drug conjugate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Du, Chang</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Dong, Changming</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Lei</au><au>Du, Chang</au><au>Zhang, Rong</au><au>Dong, Changming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy</atitle><jtitle>Chinese chemical letters</jtitle><date>2021-01</date><risdate>2021</risdate><volume>32</volume><issue>1</issue><spage>561</spage><epage>564</epage><pages>561-564</pages><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>The dual anticancer drugs-conjugated PDOXCBs nanoparticles were facilely prepared by aqueous precipitation copolymerization of two dopamine prodrugs, which integrated intrinsic photothermia of PDA with the polyprodrug-induced cocktail chemotherapy for potentialcombination cancer PTT−CCTapplication.
[Display omitted]
We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L d,l-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT−CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cclet.2020.02.043</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-7540-1082</orcidid></addata></record> |
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| ispartof | Chinese chemical letters, 2021-01, Vol.32 (1), p.561-564 |
| issn | 1001-8417 1878-5964 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Cocktail chemotherapy Combination therapy Near infrared Photothermal therapy Polymer drug conjugate |
| title | Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy |
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