Control of secondary structure and morphology of peptide–guanidiniocarbonylpyrrole conjugates by variation of the chain length

Interesting morphology and secondary structure changes were presented by three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles with different backbone length. [Display omitted] Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are kn...

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Veröffentlicht in:Chinese chemical letters 2020-05, Vol.31 (5), p.1239-1242
Hauptverfasser: Liu, Xin, Wang, Kaiya, Externbrink, Marlen, Niemeyer, Jochen, Giese, Michael, Hu, Xiao-Yu
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container_end_page 1242
container_issue 5
container_start_page 1239
container_title Chinese chemical letters
container_volume 31
creator Liu, Xin
Wang, Kaiya
Externbrink, Marlen
Niemeyer, Jochen
Giese, Michael
Hu, Xiao-Yu
description Interesting morphology and secondary structure changes were presented by three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles with different backbone length. [Display omitted] Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of nanostructures. In this work, we present three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles, which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration regimes. The random coil conformation, α-helix, and β-sheet are obtained for peptide 1, peptide 2, and peptide 3, respectively under neutral aqueous conditions. Furthermore, all peptide amphiphiles can aggregate to form nanoparticles at low concentrations. However, at high concentrations, peptide 1 self-assembles into left-handed twisted helical fibers, while longer bamboo-like morphology can be observed exclusively for peptide 2. For peptide 3, freshly prepared samples show uniform spherical morphology, whereas an obvious morphological transition from original nanoparticles to disordered fibers was realized after incubating for one week. These fascinating morphology changes were determined by the combination of circular dichroism, dynamic light scattering, transmission electron microscopy, atomic force microscopy, and theoretical calculations.
doi_str_mv 10.1016/j.cclet.2019.10.036
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[Display omitted] Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of nanostructures. In this work, we present three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles, which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration regimes. The random coil conformation, α-helix, and β-sheet are obtained for peptide 1, peptide 2, and peptide 3, respectively under neutral aqueous conditions. Furthermore, all peptide amphiphiles can aggregate to form nanoparticles at low concentrations. However, at high concentrations, peptide 1 self-assembles into left-handed twisted helical fibers, while longer bamboo-like morphology can be observed exclusively for peptide 2. 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[Display omitted] Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of nanostructures. In this work, we present three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles, which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration regimes. The random coil conformation, α-helix, and β-sheet are obtained for peptide 1, peptide 2, and peptide 3, respectively under neutral aqueous conditions. Furthermore, all peptide amphiphiles can aggregate to form nanoparticles at low concentrations. However, at high concentrations, peptide 1 self-assembles into left-handed twisted helical fibers, while longer bamboo-like morphology can be observed exclusively for peptide 2. For peptide 3, freshly prepared samples show uniform spherical morphology, whereas an obvious morphological transition from original nanoparticles to disordered fibers was realized after incubating for one week. 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[Display omitted] Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of nanostructures. In this work, we present three guanidiniocarbonylpyrrole (GCP) containing peptide amphiphiles, which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration regimes. The random coil conformation, α-helix, and β-sheet are obtained for peptide 1, peptide 2, and peptide 3, respectively under neutral aqueous conditions. Furthermore, all peptide amphiphiles can aggregate to form nanoparticles at low concentrations. However, at high concentrations, peptide 1 self-assembles into left-handed twisted helical fibers, while longer bamboo-like morphology can be observed exclusively for peptide 2. 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subjects Nanostructures
Peptide amphiphiles
pH-responsiveness
Secondary structures
Supramolecular self-assembly
title Control of secondary structure and morphology of peptide–guanidiniocarbonylpyrrole conjugates by variation of the chain length
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