Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery
Intelligent hydrogels prepared by conventional methods face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, RAFT polymerization provides a versatil...
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| Veröffentlicht in: | Chinese chemical letters 2020-01, Vol.31 (1), p.19-27 |
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| creator | Xian, Caihong Yuan, Qijuan Bao, Ziting Liu, Guiting Wu, Jun |
| description | Intelligent hydrogels prepared by conventional methods face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, and expands their applications for controlled drug delivery.
[Display omitted]
Although intelligent hydrogels have shown bright potential application in biomedical fields, they were prepared by conventional methods and still face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, such as block copolymer, graft copolymer, star copolymer. In this review, we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery. |
| doi_str_mv | 10.1016/j.cclet.2019.03.052 |
| format | Article |
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[Display omitted]
Although intelligent hydrogels have shown bright potential application in biomedical fields, they were prepared by conventional methods and still face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, such as block copolymer, graft copolymer, star copolymer. In this review, we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.</description><identifier>ISSN: 1001-8417</identifier><identifier>EISSN: 1878-5964</identifier><identifier>DOI: 10.1016/j.cclet.2019.03.052</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Drug controlled release ; Hydrogel ; RAFT polymerization ; Rapid response ; timulus-responsive</subject><ispartof>Chinese chemical letters, 2020-01, Vol.31 (1), p.19-27</ispartof><rights>2019 The Author</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-c72d783d76a443bfcc94e401061730e8c48278d54e7e4500cdd88a399c7de2f83</citedby><cites>FETCH-LOGICAL-c335t-c72d783d76a443bfcc94e401061730e8c48278d54e7e4500cdd88a399c7de2f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zghxkb/zghxkb.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cclet.2019.03.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Xian, Caihong</creatorcontrib><creatorcontrib>Yuan, Qijuan</creatorcontrib><creatorcontrib>Bao, Ziting</creatorcontrib><creatorcontrib>Liu, Guiting</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><title>Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery</title><title>Chinese chemical letters</title><description>Intelligent hydrogels prepared by conventional methods face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, and expands their applications for controlled drug delivery.
[Display omitted]
Although intelligent hydrogels have shown bright potential application in biomedical fields, they were prepared by conventional methods and still face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, such as block copolymer, graft copolymer, star copolymer. In this review, we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.</description><subject>Drug controlled release</subject><subject>Hydrogel</subject><subject>RAFT polymerization</subject><subject>Rapid response</subject><subject>timulus-responsive</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1DAQxyMEEqXwBFx840LScezEDhKHqlCKVAmEytny2pOsF9de2W4hfQieGW-3Z04zmv_HSL-meUuho0DHs11njMfS9UCnDlgHQ_-sOaFSyHaYRv687gC0lZyKl82rnHcAvZRsPGn-fk9xSZgziYG4UNB7t2AoZLvaqqDPZKMz2oP84_zyhuyjX28xuQddXAwfyCfMbgkkl6QLLut7MutNcuZRJTpYUrZI9H7vn26ZzDERE0NJ0ftabNPdQix6d49pfd28mLXP-OZpnjY_Lz_fXFy119--fL04v24NY0NpjeitkMyKUXPONrMxE0cOFEYqGKA0XPZC2oGjQD4AGGul1GyajLDYz5KdNu-Ovb91mHVY1C7epVA_qodl--fXpoe-AgNg1cmOTpNizglntU_uVqdVUVAH-GqnHuGrA3wFTFX4NfXxmKoA8d5hUtk4DAatS2iKstH9N_8PcluRiA</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Xian, Caihong</creator><creator>Yuan, Qijuan</creator><creator>Bao, Ziting</creator><creator>Liu, Guiting</creator><creator>Wu, Jun</creator><general>Elsevier B.V</general><general>Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China%Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China</general><general>Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen 518057, China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>202001</creationdate><title>Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery</title><author>Xian, Caihong ; Yuan, Qijuan ; Bao, Ziting ; Liu, Guiting ; Wu, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-c72d783d76a443bfcc94e401061730e8c48278d54e7e4500cdd88a399c7de2f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Drug controlled release</topic><topic>Hydrogel</topic><topic>RAFT polymerization</topic><topic>Rapid response</topic><topic>timulus-responsive</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xian, Caihong</creatorcontrib><creatorcontrib>Yuan, Qijuan</creatorcontrib><creatorcontrib>Bao, Ziting</creatorcontrib><creatorcontrib>Liu, Guiting</creatorcontrib><creatorcontrib>Wu, Jun</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xian, Caihong</au><au>Yuan, Qijuan</au><au>Bao, Ziting</au><au>Liu, Guiting</au><au>Wu, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery</atitle><jtitle>Chinese chemical letters</jtitle><date>2020-01</date><risdate>2020</risdate><volume>31</volume><issue>1</issue><spage>19</spage><epage>27</epage><pages>19-27</pages><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>Intelligent hydrogels prepared by conventional methods face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, and expands their applications for controlled drug delivery.
[Display omitted]
Although intelligent hydrogels have shown bright potential application in biomedical fields, they were prepared by conventional methods and still face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, such as block copolymer, graft copolymer, star copolymer. In this review, we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cclet.2019.03.052</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1001-8417 |
| ispartof | Chinese chemical letters, 2020-01, Vol.31 (1), p.19-27 |
| issn | 1001-8417 1878-5964 |
| language | eng |
| recordid | cdi_wanfang_journals_zghxkb202001003 |
| source | Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Drug controlled release Hydrogel RAFT polymerization Rapid response timulus-responsive |
| title | Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery |
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