Design, synthesis and primary activity of thiomorpholine derivatives as DPP-IV inhibitors

Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors, with natural and non-natural l-amino acids as the starting materials. Their structures were characterized by 1H NMR, 13C NMR and HR-MS. The target compounds were screened for the D...

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Veröffentlicht in:	Chinese chemical letters 2012-03, Vol.23 (3), p.297-300
Hauptverfasser:	Han, Bei, Liu, Jing Long, Huan, Yi, Li, Peng, Wu, Qi, Lin, Zi Yun, Shen, Zhu Fang, Yin, Da Li, Huang, Hai Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Dipeptidyl peptidase IV inhibitor Oral glucose tolerance test Structure–activity relationship Synthesis Thiomorpholine
Online-Zugang:	Volltext
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