The antimicrobial activities of a series of bis-quaternary ammonium compounds

The antimicrobial activities of a series of bis-quaternary ammonium compounds

A series of bis-quaternary ammonium compounds（bis-QACs） N,N＇-hevamethylenebis（1-alkyl-4-carbamoyl pyridinium bromide）（4BCAP-6,n）（alkyl chain length,n=8,10,12,14,16 and 18） were synthesized and characterized.Their surface tensions,critical micelle concentrations（CMC）,and antimicrobial activities were...

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Veröffentlicht in:Chinese chemical letters 2011-08, Vol.22 (8), p.887-890
Hauptverfasser: Sun, Xu Zhuo, Wang, Ning, Cao, Di, Hu, Zi Yu, Mao, Pu, Zhang, Hai Bo, Zhou, Xiao Hai
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Sprache:eng
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Antimicrobial activity
Bis-quaternary ammonium compounds
CMC
Minimum inhibitory concentrations
Surface activity
临界胶束浓度
双季铵盐化合物
大肠杆菌
抗菌活性
烷基链
细菌浓度
表面张力
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container_end_page 890
container_issue 8
container_start_page 887
container_title Chinese chemical letters
container_volume 22
creator Sun, Xu Zhuo
Wang, Ning
Cao, Di
Hu, Zi Yu
Mao, Pu
Zhang, Hai Bo
Zhou, Xiao Hai
description A series of bis-quaternary ammonium compounds（bis-QACs） N,N＇-hevamethylenebis（1-alkyl-4-carbamoyl pyridinium bromide）（4BCAP-6,n）（alkyl chain length,n=8,10,12,14,16 and 18） were synthesized and characterized.Their surface tensions,critical micelle concentrations（CMC）,and antimicrobial activities were evaluated.4BCAP-6,10 exhibited the strongest antimicrobial activities except for that against Proteus vulgari.The activities of 4BCAP-6.n against Escherichia coli zk126 were not significantly influenced by temperature.pH and initial bacteria concentration.These results indicate that bis-QACs exhibit high antimicrobial activity regardless of the environmental conditions.
doi_str_mv 10.1016/j.cclet.2011.01.030
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subjects Antimicrobial activity
Bis-quaternary ammonium compounds
CMC
Minimum inhibitory concentrations
Surface activity
临界胶束浓度
双季铵盐化合物
大肠杆菌
抗菌活性
烷基链
细菌浓度
表面张力
title The antimicrobial activities of a series of bis-quaternary ammonium compounds
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