Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions

Amide,which is derived from proline and is inexpensive and air-stable,has been synthesized and characterized by ~1H NMR,~(13)C NMR,and MS.It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction.In the Pd/amide catalytic system,aryl bromides can be coupled wit...

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Veröffentlicht in:Chinese chemical letters 2011-06, Vol.22 (6), p.738-740
Hauptverfasser: Liu, Hai Yang, Wang, Kun, Fu, Hai Yan, Yuan, Mao Lin, Chen, Hua, Li, Rui Xiang
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container_title Chinese chemical letters
container_volume 22
creator Liu, Hai Yang
Wang, Kun
Fu, Hai Yan
Yuan, Mao Lin
Chen, Hua
Li, Rui Xiang
description Amide,which is derived from proline and is inexpensive and air-stable,has been synthesized and characterized by ~1H NMR,~(13)C NMR,and MS.It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction.In the Pd/amide catalytic system,aryl bromides can be coupled with phenylboronic acid in ethanol/water(1:2;v/v) in excellent yields even with a low Pd loading of 0.01 mol%.Moreover,the scope of the reaction is broad,and a wide variety of functional groups are tolerant.
doi_str_mv 10.1016/j.cclet.2010.12.048
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subjects Amide
Aryl bromides
Palladium catalyst
Suzuki cross-coupling
Suzuki偶联反应
Water
乙醇/水
乙醇酰胺
交叉偶联反应
催化系统
有氧条件
配体
钯催化
title Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
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