Design and synthesis of novel cytotoxic podophyllotoxin derivatives

In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4＇-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro,...

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Veröffentlicht in:	Chinese chemical letters 2010-10, Vol.21 (10), p.1153-1156
Hauptverfasser:	Xi, Wen Li, Cai, Qian, Tang, Yan Bo, Sun, Hua, Xiao, Zhi Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	C4-derivation Cytotoxicity IC50 MCF Podophyllotoxin 化合物 细胞毒性 联动效应 肿瘤细胞 设计合成 鬼臼毒素衍生物
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