Highly Sensitive Chemiluminescence Detection for PDMS/Glass Micro-chip Electrophoresis

Highly Sensitive Chemiluminescence Detection for PDMS/Glass Micro-chip Electrophoresis

This paper described a highly sensitive chemiluminescence detection system for micro-chip electrophoresis (MCE) based on luminol-hydrogen peroxide reaction catalyzed by the metal ions. The micro-chip was composed of poly(dimethylsiloxane) (PDMS) and glass, and was fabricated by micro-machining techn...

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Veröffentlicht in:中国化学快报(英文版) 2004-06, Vol.15 (6), p.683-686
Hauptverfasser: Xiang Yi HUANG, Jiao Ning WANG, Lin CHEN, Ji Cun REN
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creator Xiang Yi HUANG
Jiao Ning WANG
Lin CHEN
Ji Cun REN
description This paper described a highly sensitive chemiluminescence detection system for micro-chip electrophoresis (MCE) based on luminol-hydrogen peroxide reaction catalyzed by the metal ions. The micro-chip was composed of poly(dimethylsiloxane) (PDMS) and glass, and was fabricated by micro-machining technology. The surface of channels was dynamically modified by polydimethylacrylamide (PDMA) in order to eliminate unhomogeneous electroosmotic flow (EOF) of the PDMS/glass chip, adsorption of molecules, and improve hydrophobicity on PDMS surface. The detection modes, reagent mix procedures and reaction conditions were optimized and the detection limit of 5 x 10-11 mol/L for cobalt (II) was achieved by MCE with chemiluminescence detection, which was about four orders of magnitude more sensitive than that reported in the reference.
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