COMBINED DETECTION OF CYCLIN D1, P27 AND DNA CONTENT IN ESOPHAGEAL CANCER
Objective： To investigate the expressions of cyclin D1 and p27 and DNA content in esophageal cancer and adjacent normal tissues, and to discuss the relationship between them. Methods： The cyclinD1 and p27 were detected by immunohistochernical staining; DNA content was measured by flow cytometry. Res...
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| Veröffentlicht in: | Chinese journal of cancer research 2006-12, Vol.18 (4), p.282-285 |
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| container_title | Chinese journal of cancer research |
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| creator | 马萍 尹元琴 王晓华 |
| description | Objective： To investigate the expressions of cyclin D1 and p27 and DNA content in esophageal cancer and adjacent normal tissues, and to discuss the relationship between them. Methods： The cyclinD1 and p27 were detected by immunohistochernical staining; DNA content was measured by flow cytometry. Results： The positive expression rates of cyclinD1 and p27 in cancer were 45.8% and 33.3% respectively, the DNA content in the positive group of cyclinD1 was higher than that in the negative group of cyclinDl（1.54±0.21 versus 1.08i-0.43, P〈0.05）, while the DNA content and SPF （S-phase fraction） in the positive group of p27 were lower than those in the negative group （1.10±0.19 and 5.56%±5.18% versus 1.66±0.28 and 19.78%±6.12%, P〈0.05）. Conclusion： The data show that the expression of cyclinD1 and p27 are related to the ontogenesis and progression of esophageal cancer. The combined detection of cyclinD1, p27 and DNA content may be indicators of diagnosis and assessment of esophageal cancer. |
| doi_str_mv | 10.1007/s11670-006-0282-8 |
| format | Article |
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Methods： The cyclinD1 and p27 were detected by immunohistochernical staining; DNA content was measured by flow cytometry. Results： The positive expression rates of cyclinD1 and p27 in cancer were 45.8% and 33.3% respectively, the DNA content in the positive group of cyclinD1 was higher than that in the negative group of cyclinDl（1.54±0.21 versus 1.08i-0.43, P〈0.05）, while the DNA content and SPF （S-phase fraction） in the positive group of p27 were lower than those in the negative group （1.10±0.19 and 5.56%±5.18% versus 1.66±0.28 and 19.78%±6.12%, P〈0.05）. Conclusion： The data show that the expression of cyclinD1 and p27 are related to the ontogenesis and progression of esophageal cancer. The combined detection of cyclinD1, p27 and DNA content may be indicators of diagnosis and assessment of esophageal cancer.</description><identifier>ISSN: 1000-9604</identifier><identifier>EISSN: 1993-0631</identifier><identifier>DOI: 10.1007/s11670-006-0282-8</identifier><language>eng</language><publisher>Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001</publisher><subject>治疗方法 ; 细胞循环 ; 蛋白质 ; 食管癌</subject><ispartof>Chinese journal of cancer research, 2006-12, Vol.18 (4), p.282-285</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1719-4cf090e758e6cffa48162b22e0cca36d197a9b024fdd91fee51fcf79277c5bac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85190X/85190X.jpg</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>马萍 尹元琴 王晓华</creatorcontrib><title>COMBINED DETECTION OF CYCLIN D1, P27 AND DNA CONTENT IN ESOPHAGEAL CANCER</title><title>Chinese journal of cancer research</title><addtitle>Chinese Journal of Cancer Research</addtitle><description>Objective： To investigate the expressions of cyclin D1 and p27 and DNA content in esophageal cancer and adjacent normal tissues, and to discuss the relationship between them. Methods： The cyclinD1 and p27 were detected by immunohistochernical staining; DNA content was measured by flow cytometry. Results： The positive expression rates of cyclinD1 and p27 in cancer were 45.8% and 33.3% respectively, the DNA content in the positive group of cyclinD1 was higher than that in the negative group of cyclinDl（1.54±0.21 versus 1.08i-0.43, P〈0.05）, while the DNA content and SPF （S-phase fraction） in the positive group of p27 were lower than those in the negative group （1.10±0.19 and 5.56%±5.18% versus 1.66±0.28 and 19.78%±6.12%, P〈0.05）. Conclusion： The data show that the expression of cyclinD1 and p27 are related to the ontogenesis and progression of esophageal cancer. The combined detection of cyclinD1, p27 and DNA content may be indicators of diagnosis and assessment of esophageal cancer.</description><subject>治疗方法</subject><subject>细胞循环</subject><subject>蛋白质</subject><subject>食管癌</subject><issn>1000-9604</issn><issn>1993-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNotkE1PwjAYxxejiYh-AG-NFy9Wn6d76XqcpcCSuRGdB09NKSuCOnSLMfDpLYHT8yT_t-QXBNcI9wjAH3rEhAMFSCiwlNH0JBigECGFJMRT_wMAFQlE58FF368BYh4DDoJcVk-PealGZKRqJeu8Kkk1JvJNFnlJRnhHZoyTrPR6mRFZlbUqa-Il9VLNptlEZQWRWSnV82Vw5sxn31wd7zB4HataTmlRTXKZFdQiR0Ej60BAw-O0SaxzJkoxYXPGGrDWhMkCBTdiDixyi4VA1zQxOuu4YJzbeG5sOAxuD71_pnWmXer15rdr_aLeLc1uu2aeAUQAwjvx4LTdpu-7xunvbvVluq1G0Htq-kBN-4TeU9Opz9wcM--bdvmz8v1-9MOtPhvNwlgAS0T4D4oMYxs</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>马萍 尹元琴 王晓华</creator><general>Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>200612</creationdate><title>COMBINED DETECTION OF CYCLIN D1, P27 AND DNA CONTENT IN ESOPHAGEAL CANCER</title><author>马萍 尹元琴 王晓华</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1719-4cf090e758e6cffa48162b22e0cca36d197a9b024fdd91fee51fcf79277c5bac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>治疗方法</topic><topic>细胞循环</topic><topic>蛋白质</topic><topic>食管癌</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>马萍 尹元琴 王晓华</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese journal of cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>马萍 尹元琴 王晓华</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMBINED DETECTION OF CYCLIN D1, P27 AND DNA CONTENT IN ESOPHAGEAL CANCER</atitle><jtitle>Chinese journal of cancer research</jtitle><addtitle>Chinese Journal of Cancer Research</addtitle><date>2006-12</date><risdate>2006</risdate><volume>18</volume><issue>4</issue><spage>282</spage><epage>285</epage><pages>282-285</pages><issn>1000-9604</issn><eissn>1993-0631</eissn><abstract>Objective： To investigate the expressions of cyclin D1 and p27 and DNA content in esophageal cancer and adjacent normal tissues, and to discuss the relationship between them. Methods： The cyclinD1 and p27 were detected by immunohistochernical staining; DNA content was measured by flow cytometry. Results： The positive expression rates of cyclinD1 and p27 in cancer were 45.8% and 33.3% respectively, the DNA content in the positive group of cyclinD1 was higher than that in the negative group of cyclinDl（1.54±0.21 versus 1.08i-0.43, P〈0.05）, while the DNA content and SPF （S-phase fraction） in the positive group of p27 were lower than those in the negative group （1.10±0.19 and 5.56%±5.18% versus 1.66±0.28 and 19.78%±6.12%, P〈0.05）. Conclusion： The data show that the expression of cyclinD1 and p27 are related to the ontogenesis and progression of esophageal cancer. The combined detection of cyclinD1, p27 and DNA content may be indicators of diagnosis and assessment of esophageal cancer.</abstract><pub>Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001</pub><doi>10.1007/s11670-006-0282-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Chinese journal of cancer research, 2006-12, Vol.18 (4), p.282-285 |
| issn | 1000-9604 1993-0631 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 治疗方法 细胞循环 蛋白质 食管癌 |
| title | COMBINED DETECTION OF CYCLIN D1, P27 AND DNA CONTENT IN ESOPHAGEAL CANCER |
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