GENE THERAPY USING RETROVIRAL VECTOR OF bcr-abl SPECIFIC MULTI-UNIT RIBOZYMES COULD INHIBIT CML CELL GROWTH AND INDUCE APOPTOSIS

Objective: To investigate the in vitro cleavage ability and effects on apoptosis and cell growth of the bcr-abl fusion gene specific multi-unit ribozymes. Methods: Three fusion point specific ribozymes were designed and the multi-unit ribozymes′ in vitro transcription vector and retroviral vector we...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chinese journal of cancer research 2003, Vol.15 (3), p.167-171
1. Verfasser:	冯琦 孙凯 赵永同 张涛 尚振川 王莎 王玮 赵宁 颜真 韩苇 张英起 孙秉中
Format:	Artikel
Sprache:	eng
Schlagworte:	bcr-abl融合基因 CML 基因疗法 基因转录 慢性白血病 细胞生长
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!