CIAPIN1与P—gp在结肠癌中的表达及意义

目的探讨CIAPIN1与P—gp在散发型结肠癌中的表达及其与耐药性的关系。方法应用sP免疫组化法检测65例结肠癌组织标本中CIAPIN1与P—gP的分布和表达并分析其相关性。结果CIAPIN1与P—gP的阳性表达率分别为69.2%、52.3%,其表达不受性别、年龄、肿瘤部位、分化程度的影响,但不同Duke’s分期的癌组织中的表达有显著性差异(P〈0.05),相关分析显示二者表达呈显著正相关(P〈0.05)。结论CIAPIN1与P—gP在结肠癌进展中起重要作用,高表达CIAPIN1与P—gP的肿瘤组织具有较强的浸润与转移能力,并可能导致多药耐药的发生。...

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Veröffentlicht in:医学新知杂志 2013, Vol.23 (6), p.402-404
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description 目的探讨CIAPIN1与P—gp在散发型结肠癌中的表达及其与耐药性的关系。方法应用sP免疫组化法检测65例结肠癌组织标本中CIAPIN1与P—gP的分布和表达并分析其相关性。结果CIAPIN1与P—gP的阳性表达率分别为69.2%、52.3%,其表达不受性别、年龄、肿瘤部位、分化程度的影响,但不同Duke’s分期的癌组织中的表达有显著性差异(P〈0.05),相关分析显示二者表达呈显著正相关(P〈0.05)。结论CIAPIN1与P—gP在结肠癌进展中起重要作用,高表达CIAPIN1与P—gP的肿瘤组织具有较强的浸润与转移能力,并可能导致多药耐药的发生。
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subjects ICIAPIN1
P—gP
结肠癌
title CIAPIN1与P—gp在结肠癌中的表达及意义
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