布洛芬-羟丙基-β-环糊精及布洛芬-β-环糊精微观结构的原子力显微镜表征
R943; 采用原子力显微镜(AFM)表征布洛芬-羟丙基-β-环糊精(IBU-HP-β-CyD)及布洛芬-β-环糊精(IBU-β-CyD)微观结构.测定条件为:钨丝探针(力常数0.06 N·m-1),扫描范围10.5 nm×10.5 nm,轻敲模式下成像,室温下逐点采集数据,G3DR软件处理数据.结果表明,β-CyD与HP-β-CyD空穴外径为1.53 nm,布洛芬的苯环直径为0.62 nm,布洛芬的苯环及其疏水基团插入HP-β-CyD与β-CyD空穴,形成1:1的包合物.红外光谱、X-射线衍射和相溶解度佐证了AFM测定结果....
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| Veröffentlicht in: | 药学学报 2008, Vol.43 (9), p.969-973 |
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| container_title | 药学学报 |
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| creator | 王丽娟 朱照静 车坷科 鞠凤阁 |
| description | R943; 采用原子力显微镜(AFM)表征布洛芬-羟丙基-β-环糊精(IBU-HP-β-CyD)及布洛芬-β-环糊精(IBU-β-CyD)微观结构.测定条件为:钨丝探针(力常数0.06 N·m-1),扫描范围10.5 nm×10.5 nm,轻敲模式下成像,室温下逐点采集数据,G3DR软件处理数据.结果表明,β-CyD与HP-β-CyD空穴外径为1.53 nm,布洛芬的苯环直径为0.62 nm,布洛芬的苯环及其疏水基团插入HP-β-CyD与β-CyD空穴,形成1:1的包合物.红外光谱、X-射线衍射和相溶解度佐证了AFM测定结果. |
| doi_str_mv | 10.3321/j.issn:0513-4870.2008.09.017 |
| format | Article |
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| title | 布洛芬-羟丙基-β-环糊精及布洛芬-β-环糊精微观结构的原子力显微镜表征 |
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