Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma
Objective: To study the correlation between mi R-21 and Treg/Th17 ratio in the microenvironment of rats with hepatocellular carcinoma. Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in t...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2015-09, Vol.8 (9), p.747-750 |
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| container_title | Asian Pacific journal of tropical medicine |
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| creator | Yao, Shao-Xin Zhang, Gui-Song Cao, Hong-Xia Song, Guang Li, Zang-Tuo Zhang, Wei-Tao |
| description | Objective: To study the correlation between mi R-21 and Treg/Th17 ratio in the microenvironment of rats with hepatocellular carcinoma. Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in the peripheral blood of rats with hepatocellular carcinoma were detected. The statistical analysis was performed on the correlation between mi R-21 expression and Treg/Th17 ratio. Results: Hepatocellular carcinoma model of rats was successfully constructed. The proportion of Th17 cells among all CD4+T cells in the peripheral blood of rats with hepatocellular carcinoma was 5.319%, which was higher than the control group; while the proportion of Treg cells was 9.472%, which was higher than the control group. Treg/Th17 ratio in the model group was 1.781, compared with 1.478 in the control group. The expression of mi R-21 was increased in the peripheral blood of rats with hepatocellular carcinoma and it showed a positive correlation with the ratio of Treg/Th17. Conclusions: There is a positive correlation between the expression level of miR-21 and the ratio of Treg/Th17. |
| doi_str_mv | 10.1016/j.apjtm.2015.07.021 |
| format | Article |
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Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in the peripheral blood of rats with hepatocellular carcinoma were detected. The statistical analysis was performed on the correlation between mi R-21 expression and Treg/Th17 ratio. Results: Hepatocellular carcinoma model of rats was successfully constructed. The proportion of Th17 cells among all CD4+T cells in the peripheral blood of rats with hepatocellular carcinoma was 5.319%, which was higher than the control group; while the proportion of Treg cells was 9.472%, which was higher than the control group. Treg/Th17 ratio in the model group was 1.781, compared with 1.478 in the control group. The expression of mi R-21 was increased in the peripheral blood of rats with hepatocellular carcinoma and it showed a positive correlation with the ratio of Treg/Th17. Conclusions: There is a positive correlation between the expression level of miR-21 and the ratio of Treg/Th17.</description><identifier>ISSN: 1995-7645</identifier><identifier>EISSN: 2352-4146</identifier><identifier>DOI: 10.1016/j.apjtm.2015.07.021</identifier><identifier>PMID: 26433664</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>analysis ; carcinoma ; Cells ; Correlation ; Correlation analysis ; Hepatocellular ; Hepatocellular carcinoma ; miR-21 ; Th17 ; Th17 cells ; Treg ; Treg cells</subject><ispartof>Asian Pacific journal of tropical medicine, 2015-09, Vol.8 (9), p.747-750</ispartof><rights>2015 Hainan Medical College</rights><rights>Copyright © 2015 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-d4ffa170a170e88c5f4c000bddbf0f0e0c31c14b8dbd21199c2a94b30df479d43</citedby><cites>FETCH-LOGICAL-c553t-d4ffa170a170e88c5f4c000bddbf0f0e0c31c14b8dbd21199c2a94b30df479d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apjtm.2015.07.021$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26433664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Shao-Xin</creatorcontrib><creatorcontrib>Zhang, Gui-Song</creatorcontrib><creatorcontrib>Cao, Hong-Xia</creatorcontrib><creatorcontrib>Song, Guang</creatorcontrib><creatorcontrib>Li, Zang-Tuo</creatorcontrib><creatorcontrib>Zhang, Wei-Tao</creatorcontrib><title>Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma</title><title>Asian Pacific journal of tropical medicine</title><addtitle>亚太热带医药杂志(英文版)</addtitle><description>Objective: To study the correlation between mi R-21 and Treg/Th17 ratio in the microenvironment of rats with hepatocellular carcinoma. Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in the peripheral blood of rats with hepatocellular carcinoma were detected. The statistical analysis was performed on the correlation between mi R-21 expression and Treg/Th17 ratio. Results: Hepatocellular carcinoma model of rats was successfully constructed. The proportion of Th17 cells among all CD4+T cells in the peripheral blood of rats with hepatocellular carcinoma was 5.319%, which was higher than the control group; while the proportion of Treg cells was 9.472%, which was higher than the control group. Treg/Th17 ratio in the model group was 1.781, compared with 1.478 in the control group. The expression of mi R-21 was increased in the peripheral blood of rats with hepatocellular carcinoma and it showed a positive correlation with the ratio of Treg/Th17. Conclusions: There is a positive correlation between the expression level of miR-21 and the ratio of Treg/Th17.</description><subject>analysis</subject><subject>carcinoma</subject><subject>Cells</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Hepatocellular</subject><subject>Hepatocellular carcinoma</subject><subject>miR-21</subject><subject>Th17</subject><subject>Th17 cells</subject><subject>Treg</subject><subject>Treg cells</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkV9r2zAUxcXYWEPWTzAYfhwDe5Il_9HDHkro1kHZYGTPQpauExlbciWnWfqyr165TvY6gZAQv3vPPToIvSc4I5iUn7tMjt00ZDkmRYarDOfkFVrltMhTRlj5Gq0I50Valay4QtchdDgumnNe0bfoKi8ZpWXJVujvxnkPvZyMs0kD0xHAJoNR3v36cZPmJJFWJ_Bn9BDCjLg22e5J9fK89bBLFPR9SMy5COyj8c4OYKcZ9XIKydFM-2QPo5zcDB966RMlvTLWDfIdetPKPsD1-Vyj319vt5u79P7nt--bm_tUFQWdUs3aVpIKzxvqWhUtU9FQo3XT4hYDVpQowppaNzon0brKJWcNxbplFdeMrtGnpe9R2lbanejcwduoKE5en05PTwLmr8Qckxn-uMCjdw8HCJMYTJhnlxbcIQhSEc4Ir-Noa0QXNJoPwUMrRm8G6U-CYDEnJTrxkpSY2wtciZhUrPpwFjg0A-h_NZdcIvBlASD-yaMBL4IyYBVo40FNQjvzH4HLWHtndw8mGr5o1LxmdV7zArOa8YKyuqiWG30GOnq2Ew</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Yao, Shao-Xin</creator><creator>Zhang, Gui-Song</creator><creator>Cao, Hong-Xia</creator><creator>Song, Guang</creator><creator>Li, Zang-Tuo</creator><creator>Zhang, Wei-Tao</creator><general>Elsevier B.V</general><general>Department of Interventional Therapy, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei, 063000%Department of Interventional Therapy, Luanxian People's Hospital, Tangshan, Hebei, 063700</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20150901</creationdate><title>Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma</title><author>Yao, Shao-Xin ; Zhang, Gui-Song ; Cao, Hong-Xia ; Song, Guang ; Li, Zang-Tuo ; Zhang, Wei-Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-d4ffa170a170e88c5f4c000bddbf0f0e0c31c14b8dbd21199c2a94b30df479d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>analysis</topic><topic>carcinoma</topic><topic>Cells</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Hepatocellular</topic><topic>Hepatocellular carcinoma</topic><topic>miR-21</topic><topic>Th17</topic><topic>Th17 cells</topic><topic>Treg</topic><topic>Treg cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Shao-Xin</creatorcontrib><creatorcontrib>Zhang, Gui-Song</creatorcontrib><creatorcontrib>Cao, Hong-Xia</creatorcontrib><creatorcontrib>Song, Guang</creatorcontrib><creatorcontrib>Li, Zang-Tuo</creatorcontrib><creatorcontrib>Zhang, Wei-Tao</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Asian Pacific journal of tropical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Shao-Xin</au><au>Zhang, Gui-Song</au><au>Cao, Hong-Xia</au><au>Song, Guang</au><au>Li, Zang-Tuo</au><au>Zhang, Wei-Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma</atitle><jtitle>Asian Pacific journal of tropical medicine</jtitle><addtitle>亚太热带医药杂志(英文版)</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>8</volume><issue>9</issue><spage>747</spage><epage>750</epage><pages>747-750</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract>Objective: To study the correlation between mi R-21 and Treg/Th17 ratio in the microenvironment of rats with hepatocellular carcinoma. Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in the peripheral blood of rats with hepatocellular carcinoma were detected. The statistical analysis was performed on the correlation between mi R-21 expression and Treg/Th17 ratio. Results: Hepatocellular carcinoma model of rats was successfully constructed. The proportion of Th17 cells among all CD4+T cells in the peripheral blood of rats with hepatocellular carcinoma was 5.319%, which was higher than the control group; while the proportion of Treg cells was 9.472%, which was higher than the control group. Treg/Th17 ratio in the model group was 1.781, compared with 1.478 in the control group. The expression of mi R-21 was increased in the peripheral blood of rats with hepatocellular carcinoma and it showed a positive correlation with the ratio of Treg/Th17. Conclusions: There is a positive correlation between the expression level of miR-21 and the ratio of Treg/Th17.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>26433664</pmid><doi>10.1016/j.apjtm.2015.07.021</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | analysis carcinoma Cells Correlation Correlation analysis Hepatocellular Hepatocellular carcinoma miR-21 Th17 Th17 cells Treg Treg cells |
| title | Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma |
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