Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma
Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.Methods:A total of 297 patients from July 2009 to May 2013 were chosen as objects.EGFR gene mutation were detected with fluorescence quantitative PCR.Relevan...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2015-03, Vol.8 (3), p.249-252 |
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| creator | Wang, Cheng-De Wang, Xin-Rong Wang, Chao-Yang Tang, Yi-Jun Hao, Ming-Wen |
| description | Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.Methods:A total of 297 patients from July 2009 to May 2013 were chosen as objects.EGFR gene mutation were detected with fluorescence quantitative PCR.Relevance of EGFR gene mutation with clinical and pathological features was analyzed,and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was compared.Results:In 297 patients.136(45.79%) showed EGFR gene mutation.EGFR gene mutation had no significant relevance with age.gender,smoking history,family history of cancer and clinical stage(P>0.05);there was significant relevance between EGFR gene mutation and blood type,pathologic types,differentiation and diameter of cancer(P<0.05).The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance(P<0.05).Conclusions:EGFR gene mutation has significant relevance with pathological features,the prognosis of EGFRmutant-paticnts is better than that of EGFR- wide type-patients. |
| doi_str_mv | 10.1016/S1995-7645(14)60326-6 |
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Production and hosting by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-7a6f029e6f8da77fd7a8532429fe0bf94d6df551e34ab7478ce97c171cda7a553</citedby><cites>FETCH-LOGICAL-c491t-7a6f029e6f8da77fd7a8532429fe0bf94d6df551e34ab7478ce97c171cda7a553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1995764514603266$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25902172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Cheng-De</creatorcontrib><creatorcontrib>Wang, Xin-Rong</creatorcontrib><creatorcontrib>Wang, Chao-Yang</creatorcontrib><creatorcontrib>Tang, Yi-Jun</creatorcontrib><creatorcontrib>Hao, Ming-Wen</creatorcontrib><title>Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma</title><title>Asian Pacific journal of tropical medicine</title><addtitle>亚太热带医药杂志(英文版)</addtitle><description>Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.Methods:A total of 297 patients from July 2009 to May 2013 were chosen as objects.EGFR gene mutation were detected with fluorescence quantitative PCR.Relevance of EGFR gene mutation with clinical and pathological features was analyzed,and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was compared.Results:In 297 patients.136(45.79%) showed EGFR gene mutation.EGFR gene mutation had no significant relevance with age.gender,smoking history,family history of cancer and clinical stage(P&gt;0.05);there was significant relevance between EGFR gene mutation and blood type,pathologic types,differentiation and diameter of cancer(P&lt;0.05).The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance(P&lt;0.05).Conclusions:EGFR gene mutation has significant relevance with pathological features,the prognosis of EGFRmutant-paticnts is better than that of EGFR- wide type-patients.</description><subject>carcinoma</subject><subject>Epidermal</subject><subject>Epidermal growth factor receptor</subject><subject>factor</subject><subject>features</subject><subject>Fluorescence</subject><subject>Fluorescence quantitative PCR</subject><subject>growth</subject><subject>lung</subject><subject>Non-small-cell</subject><subject>Non–small–cell lung carcinoma</subject><subject>Pathological</subject><subject>Pathological features</subject><subject>PCR</subject><subject>Prognosis</subject><subject>quantitative</subject><subject>receptor</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkU1P3DAQhqOqVVlRfkIrHylSqL8dn6oKAUVCqkTbs-V1JlmjxF7shNXy6-v9gGt9GR-ed96ZeavqM8GXBBP57TfRWtRKcnFO-FeJGZW1fFctKBO05oTL99XiDTmpznJ-xOUxqrViH6sTKjSmRNFFtXmAAZ5tcIBih65vbx5QDwHQOE928jGgjZ9WaG2nVRxi750dUAd2mhNkZEOL1in2IWafkQ87zEOY8kEUYqjzaIehdjAMaJhDj5xNzoc42k_Vh84OGc6O9bT6e3P95-pnff_r9u7qx33tuCZTrazsMNUgu6a1SnWtso1glFPdAV52mrey7YQgwLhdKq4aB1o5oogruBWCnVYXh74bGzobevMY5xSKo9mmdrt9eTFAMRGYYaIKfH6Ay1ZPM-TJjD7vhrcB4pwNkUo0ShJJCioOqEsx5wSdWSc_2rQ1BJtdRmafkdkFYAg3-4yMLLovR4t5OUL7pnpNpADfDwCUqzx7SCa7clQHrU_gJtNG_18LdhxtFUP_5MvSry6NbnhDGy0wb7gWjDeC7H-S_QOQGrF1</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Wang, Cheng-De</creator><creator>Wang, Xin-Rong</creator><creator>Wang, Chao-Yang</creator><creator>Tang, Yi-Jun</creator><creator>Hao, Ming-Wen</creator><general>Elsevier B.V</general><general>Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province,China%Department of Reproductive Medicine, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20150301</creationdate><title>Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma</title><author>Wang, Cheng-De ; Wang, Xin-Rong ; Wang, Chao-Yang ; Tang, Yi-Jun ; Hao, Ming-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-7a6f029e6f8da77fd7a8532429fe0bf94d6df551e34ab7478ce97c171cda7a553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>carcinoma</topic><topic>Epidermal</topic><topic>Epidermal growth factor receptor</topic><topic>factor</topic><topic>features</topic><topic>Fluorescence</topic><topic>Fluorescence quantitative PCR</topic><topic>growth</topic><topic>lung</topic><topic>Non-small-cell</topic><topic>Non–small–cell lung carcinoma</topic><topic>Pathological</topic><topic>Pathological features</topic><topic>PCR</topic><topic>Prognosis</topic><topic>quantitative</topic><topic>receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Cheng-De</creatorcontrib><creatorcontrib>Wang, Xin-Rong</creatorcontrib><creatorcontrib>Wang, Chao-Yang</creatorcontrib><creatorcontrib>Tang, Yi-Jun</creatorcontrib><creatorcontrib>Hao, Ming-Wen</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Asian Pacific journal of tropical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Cheng-De</au><au>Wang, Xin-Rong</au><au>Wang, Chao-Yang</au><au>Tang, Yi-Jun</au><au>Hao, Ming-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma</atitle><jtitle>Asian Pacific journal of tropical medicine</jtitle><addtitle>亚太热带医药杂志(英文版)</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>8</volume><issue>3</issue><spage>249</spage><epage>252</epage><pages>249-252</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract>Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.Methods:A total of 297 patients from July 2009 to May 2013 were chosen as objects.EGFR gene mutation were detected with fluorescence quantitative PCR.Relevance of EGFR gene mutation with clinical and pathological features was analyzed,and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was compared.Results:In 297 patients.136(45.79%) showed EGFR gene mutation.EGFR gene mutation had no significant relevance with age.gender,smoking history,family history of cancer and clinical stage(P&gt;0.05);there was significant relevance between EGFR gene mutation and blood type,pathologic types,differentiation and diameter of cancer(P&lt;0.05).The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance(P&lt;0.05).Conclusions:EGFR gene mutation has significant relevance with pathological features,the prognosis of EGFRmutant-paticnts is better than that of EGFR- wide type-patients.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>25902172</pmid><doi>10.1016/S1995-7645(14)60326-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | carcinoma Epidermal Epidermal growth factor receptor factor features Fluorescence Fluorescence quantitative PCR growth lung Non-small-cell Non–small–cell lung carcinoma Pathological Pathological features PCR Prognosis quantitative receptor |
| title | Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma |
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