Effects of aspirin on fracture healing in OPF rats
Objective:To study the effect of aspirin on healing process of osteoporotic fracture(OPF)in rats.Methods:A total of 50 female Wistar rata aged 3 months were randomly divided into observation group and control group,castration method was adopted to establish the osteoporosis(OP)model.After artificial...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2014-10, Vol.7 (10), p.801-805 |
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| creator | Wei, Jin-Song Zeng, Rong Chen, Si-Yuan Lin, Hao Wu, Shao-Ke Zheng, Jin-Chang |
| description | Objective:To study the effect of aspirin on healing process of osteoporotic fracture(OPF)in rats.Methods:A total of 50 female Wistar rata aged 3 months were randomly divided into observation group and control group,castration method was adopted to establish the osteoporosis(OP)model.After artificial preparing fractures on the midpoint of left femur,fixing gram needle intramedullary.OPF modeling was complete.Aspirin lavage of 33 mg once a day was adoptde in observation group after modeling,same amount of normal saline was used in the control as placebo.From eash group,selected 5 rats at the 2nd.4th,8th and 12th week after modeling to measure the bone mineral density(BMD)and histogical examination of the fracture callus,radiology observation was conducted at the 8th and 12th week.Left femur biomechanical measurement was taken at the 12th week.Results:BMD values of observation group at each time point were significantly higher than that of the control group after modeling(P<0.05);Histological observation showed that at the 8th week,the endochondral ossification process of observation group was faster than that of observation group,with fuzzy fracture line in observation group and clear fracture line in observtion group;at the 12th week,fracture line disappeared in observation group,fracture line of the control group was fuzzy at the same time;three-point bending load of the left femur in observation group rats was significantly higher than that of control group after12 weeka(P<0.05).Conclusions:Asporin can accelerate the healing of new callus in OPF rats,increase bone density and biomechanics strength,and promote fracture of osteporotic rats. |
| doi_str_mv | 10.1016/S1995-7645(14)60140-1 |
| format | Article |
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Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-c80765f0b9a8cba8217ae5eae0b302e44ed24572af335922a2a777d80f1ef9f03</citedby><cites>FETCH-LOGICAL-c508t-c80765f0b9a8cba8217ae5eae0b302e44ed24572af335922a2a777d80f1ef9f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1995764514601401$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25129464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Jin-Song</creatorcontrib><creatorcontrib>Zeng, Rong</creatorcontrib><creatorcontrib>Chen, Si-Yuan</creatorcontrib><creatorcontrib>Lin, Hao</creatorcontrib><creatorcontrib>Wu, Shao-Ke</creatorcontrib><creatorcontrib>Zheng, Jin-Chang</creatorcontrib><title>Effects of aspirin on fracture healing in OPF rats</title><title>Asian Pacific journal of tropical medicine</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description>Objective:To study the effect of aspirin on healing process of osteoporotic fracture(OPF)in rats.Methods:A total of 50 female Wistar rata aged 3 months were randomly divided into observation group and control group,castration method was adopted to establish the osteoporosis(OP)model.After artificial preparing fractures on the midpoint of left femur,fixing gram needle intramedullary.OPF modeling was complete.Aspirin lavage of 33 mg once a day was adoptde in observation group after modeling,same amount of normal saline was used in the control as placebo.From eash group,selected 5 rats at the 2nd.4th,8th and 12th week after modeling to measure the bone mineral density(BMD)and histogical examination of the fracture callus,radiology observation was conducted at the 8th and 12th week.Left femur biomechanical measurement was taken at the 12th week.Results:BMD values of observation group at each time point were significantly higher than that of the control group after modeling(P&lt;0.05);Histological observation showed that at the 8th week,the endochondral ossification process of observation group was faster than that of observation group,with fuzzy fracture line in observation group and clear fracture line in observtion group;at the 12th week,fracture line disappeared in observation group,fracture line of the control group was fuzzy at the same time;three-point bending load of the left femur in observation group rats was significantly higher than that of control group after12 weeka(P&lt;0.05).Conclusions:Asporin can accelerate the healing of new callus in OPF rats,increase bone density and biomechanics strength,and promote fracture of osteporotic rats.</description><subject>Aspirin</subject><subject>Fracture</subject><subject>Healing</subject><subject>Osteoporosis</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkV1LXDEQhoNYdLH-hMoBb1Q4Nd8fV1JE24JgQb0O2ZzJGtnNWZNzKuuvN-tupXfmZiA8M-_M-yL0jeDvBBN5fkeMEa2SXJwQfiox4bglO2hCmaAtJ1zuoskHso8OS3nC9TFqjGJ7aJ8KQg2XfILoVQjgh9L0oXFlGXNMTZ-akJ0fxgzNI7h5TLOmft_-uW6yG8pX9CW4eYHDbT1AD9dX95e_2pvbn78vf9y0XmA9tF5jJUXAU-O0nzpNiXIgwAGeMkyBc-goF4q6wJgwlDrqlFKdxoFAMAGzA3S2mfviUnBpZp_6MaeqaFe5W61eXy3QejnBmKzhkw28zP3zCGWwi1g8zOcuQT8WS6TEzFAj1OeoEJxLLaiuqNigPvelZAh2mePC5ZUl2K6TsO9J2LXNlnD7noQlte9oKzFOF9B9dP3zvQIXGwCqgX8jZFt8hOShi7nGYbs-fipxvF3tsU-z55rRf7thwag2WrI3_uGgrA</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Wei, Jin-Song</creator><creator>Zeng, Rong</creator><creator>Chen, Si-Yuan</creator><creator>Lin, Hao</creator><creator>Wu, Shao-Ke</creator><creator>Zheng, Jin-Chang</creator><general>Elsevier B.V</general><general>Department of 0rthopaedics, Guangdong Medical University Affiliated Hospital, Zhanjiang, Guangdong 524001, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20141001</creationdate><title>Effects of aspirin on fracture healing in OPF rats</title><author>Wei, Jin-Song ; Zeng, Rong ; Chen, Si-Yuan ; Lin, Hao ; Wu, Shao-Ke ; Zheng, Jin-Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-c80765f0b9a8cba8217ae5eae0b302e44ed24572af335922a2a777d80f1ef9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aspirin</topic><topic>Fracture</topic><topic>Healing</topic><topic>Osteoporosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Jin-Song</creatorcontrib><creatorcontrib>Zeng, Rong</creatorcontrib><creatorcontrib>Chen, Si-Yuan</creatorcontrib><creatorcontrib>Lin, Hao</creatorcontrib><creatorcontrib>Wu, Shao-Ke</creatorcontrib><creatorcontrib>Zheng, Jin-Chang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Asian Pacific journal of tropical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Jin-Song</au><au>Zeng, Rong</au><au>Chen, Si-Yuan</au><au>Lin, Hao</au><au>Wu, Shao-Ke</au><au>Zheng, Jin-Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of aspirin on fracture healing in OPF rats</atitle><jtitle>Asian Pacific journal of tropical medicine</jtitle><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>7</volume><issue>10</issue><spage>801</spage><epage>805</epage><pages>801-805</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract>Objective:To study the effect of aspirin on healing process of osteoporotic fracture(OPF)in rats.Methods:A total of 50 female Wistar rata aged 3 months were randomly divided into observation group and control group,castration method was adopted to establish the osteoporosis(OP)model.After artificial preparing fractures on the midpoint of left femur,fixing gram needle intramedullary.OPF modeling was complete.Aspirin lavage of 33 mg once a day was adoptde in observation group after modeling,same amount of normal saline was used in the control as placebo.From eash group,selected 5 rats at the 2nd.4th,8th and 12th week after modeling to measure the bone mineral density(BMD)and histogical examination of the fracture callus,radiology observation was conducted at the 8th and 12th week.Left femur biomechanical measurement was taken at the 12th week.Results:BMD values of observation group at each time point were significantly higher than that of the control group after modeling(P&lt;0.05);Histological observation showed that at the 8th week,the endochondral ossification process of observation group was faster than that of observation group,with fuzzy fracture line in observation group and clear fracture line in observtion group;at the 12th week,fracture line disappeared in observation group,fracture line of the control group was fuzzy at the same time;three-point bending load of the left femur in observation group rats was significantly higher than that of control group after12 weeka(P&lt;0.05).Conclusions:Asporin can accelerate the healing of new callus in OPF rats,increase bone density and biomechanics strength,and promote fracture of osteporotic rats.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>25129464</pmid><doi>10.1016/S1995-7645(14)60140-1</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aspirin Fracture Healing Osteoporosis |
| title | Effects of aspirin on fracture healing in OPF rats |
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