In vitro study on blocking mTOR signaling pathway in EGFR-TKI resistance NSCLC

Objective:To investigate the effect and mechanism of inhibitor everolimus on EGFR-TKI resistance NSCLC.Methods:MTT assay was used to detect proliferation of human non-small cell lung cancer cell line A549.Flow cytometry was used to detect the changes of apoptosis and cycle distribution in each group...

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Veröffentlicht in:	Asian Pacific journal of tropical medicine 2014-05, Vol.7 (5), p.394-397
Hauptverfasser:	Xiang, Xu-Dong, Yu, Jing, Li, Gao-Feng, Xie, Lin, Li, Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - analysis Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Proliferation - drug effects EGFR Everolimus Gene Expression Regulation, Neoplastic - drug effects Humans Lung Neoplasms - metabolism mTOR NSCLC Phosphoproteins - analysis Phosphoproteins - genetics Phosphoproteins - metabolism PTEN Phosphohydrolase - analysis PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Signal Transduction - drug effects Sirolimus - analogs & derivatives Sirolimus - pharmacology Targeted Targeted therapy therapy TOR Serine-Threonine Kinases - metabolism
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