Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats
Objective:To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:Sixty Wistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligati...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2013-12, Vol.6 (12), p.986-989 |
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| creator | Liu, Hong-Bo Lin, Chun-Hua Zhou, Guang-Yu Chen, Guo-Zhen Cai, Wei-Yan |
| description | Objective:To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:Sixty Wistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method.Rats in A and B groups were intragastrically administered with physiological saline,while C and D groups were administered with Xinjikang and metoprolol,respectively.The changes in blood pressure.E/A ratio,myocardial pathological morphology,myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.Results:There were statistically significant differences in E/A ratio between C group after treatment and model group(P<0.05).while no difference was observed between A and D groups(P>0.05);after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group(P<0.05).Conclusions:Xinjikang can improve myocardial injury,restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy. |
| doi_str_mv | 10.1016/S1995-7645(13)60177-7 |
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Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c456t-b7728bcc763160817755d836cd769f007df3c58e10f53cb31d6f503a3b6307c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1995-7645(13)60177-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24144033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Hong-Bo</creatorcontrib><creatorcontrib>Lin, Chun-Hua</creatorcontrib><creatorcontrib>Zhou, Guang-Yu</creatorcontrib><creatorcontrib>Chen, Guo-Zhen</creatorcontrib><creatorcontrib>Cai, Wei-Yan</creatorcontrib><title>Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats</title><title>Asian Pacific journal of tropical medicine</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description>Objective:To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:Sixty Wistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method.Rats in A and B groups were intragastrically administered with physiological saline,while C and D groups were administered with Xinjikang and metoprolol,respectively.The changes in blood pressure.E/A ratio,myocardial pathological morphology,myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.Results:There were statistically significant differences in E/A ratio between C group after treatment and model group(P&lt;0.05).while no difference was observed between A and D groups(P&gt;0.05);after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group(P&lt;0.05).Conclusions:Xinjikang can improve myocardial injury,restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.</description><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>hypertrophy</subject><subject>Left</subject><subject>Left ventricular hypertrophy</subject><subject>Male</subject><subject>Metoprolol - pharmacology</subject><subject>Metoprolol - therapeutic use</subject><subject>Myocardium - chemistry</subject><subject>Myocardium - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>ventricular</subject><subject>Ventricular Remodeling - drug effects</subject><subject>Xinjikang</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQgC0EoqvSnwCKxKUghdoZP5ITqqpCK1XqoSBxsxJn3PWStbd2sij99Xi7S8WtPtiH-cbz-Ah5z-gXRpk8u2NNI0oluThl8ElSplSpXpFFBaIqOePyNVk8I0fkJKUVzQeqplHwlhxVmeEUYEHuLq1FMxbBFr-cX7nfrb8vgi8GtGOxRT9GZ6ahjcVy3mAcY9gs5yLiOvQ4uIw6f4igT26LRWzH9I68se2Q8OTwHpOf3y5_XFyVN7ffry_Ob0rDhRzLTqmq7oxREpikdZ5BiL4GaXolG0up6i0YUSOjVoDpgPXSCgotdBKoMg0ck8_7f_-03ua-9SpM0eeKeo79PD8-aqwoA5YvluHTPbyJ4WHCNOq1SwaHofUYpqSZlJTn_Sn6Mso5h4bVfIeKPWpiSCmi1Zvo1m2cNaN6p0o_qdI7D5qBflKlVc77cCgxdWvsn7P-icnA1z2AeYFbh1En49Ab7F3MvnQf3IslPh5aWwZ__5Bl_dcbBQp5Ug5_AV3KrbA</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Liu, Hong-Bo</creator><creator>Lin, Chun-Hua</creator><creator>Zhou, Guang-Yu</creator><creator>Chen, Guo-Zhen</creator><creator>Cai, Wei-Yan</creator><general>Elsevier B.V</general><general>Yuhuangding Hospital of Yantai, Yantai 264000, Shandong Province, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20131201</creationdate><title>Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats</title><author>Liu, Hong-Bo ; Lin, Chun-Hua ; Zhou, Guang-Yu ; Chen, Guo-Zhen ; Cai, Wei-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b7728bcc763160817755d836cd769f007df3c58e10f53cb31d6f503a3b6307c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - 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| identifier | ISSN: 1995-7645 |
| ispartof | Asian Pacific journal of tropical medicine, 2013-12, Vol.6 (12), p.986-989 |
| issn | 1995-7645 2352-4146 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Hypertension Hypertension - drug therapy hypertrophy Left Left ventricular hypertrophy Male Metoprolol - pharmacology Metoprolol - therapeutic use Myocardium - chemistry Myocardium - pathology Rats Rats, Wistar ventricular Ventricular Remodeling - drug effects Xinjikang |
| title | Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats |
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