Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica
<正>Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-i...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2013-04, Vol.6 (4), p.311-314 |
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| creator | Mohan, CG Deepak, M Viswanatha, GL Savinay, G Hanumantharaju, V Rajendra, CE Halemani, Praveen D |
| description | <正>Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract（MEMI）,successive water extract （SWMI） and ethyl acetate fraction（EMEMI）,n-butanol fraction（BMEMI） and water soluble fraction （WMEMI） of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. |
| doi_str_mv | 10.1016/S1995-7645(13)60062-0 |
| format | Article |
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Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions.</description><identifier>ISSN: 1995-7645</identifier><identifier>EISSN: 2352-4146</identifier><identifier>DOI: 10.1016/S1995-7645(13)60062-0</identifier><identifier>PMID: 23608334</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>Anti-inflammatory ; Anti-Inflammatory Agents - chemistry ; Antioxidants ; Antioxidants - chemistry ; assay ; Biphenyl Compounds - chemistry ; DPPH ; DPPH assay ; indica ; Lipoxygenase ; Lipoxygenase - analysis ; Lipoxygenase Inhibitors - chemistry ; Mangifera ; Mangifera indica ; Picrates - chemistry ; Plant Extracts - chemistry ; Plant Leaves</subject><ispartof>Asian Pacific journal of tropical medicine, 2013-04, Vol.6 (4), p.311-314</ispartof><rights>2013 Hainan Medical College</rights><rights>Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-b302364d688d4b3c4fed29bb70b37798ddd13297caea6553ae84ba10da0197293</citedby><cites>FETCH-LOGICAL-c527t-b302364d688d4b3c4fed29bb70b37798ddd13297caea6553ae84ba10da0197293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1995764513600620$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23608334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohan, CG</creatorcontrib><creatorcontrib>Deepak, M</creatorcontrib><creatorcontrib>Viswanatha, GL</creatorcontrib><creatorcontrib>Savinay, G</creatorcontrib><creatorcontrib>Hanumantharaju, V</creatorcontrib><creatorcontrib>Rajendra, CE</creatorcontrib><creatorcontrib>Halemani, Praveen D</creatorcontrib><title>Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica</title><title>Asian Pacific journal of tropical medicine</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description>&lt;正&gt;Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract（MEMI）,successive water extract （SWMI） and ethyl acetate fraction（EMEMI）,n-butanol fraction（BMEMI） and water soluble fraction （WMEMI） of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions.</description><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>assay</subject><subject>Biphenyl Compounds - chemistry</subject><subject>DPPH</subject><subject>DPPH assay</subject><subject>indica</subject><subject>Lipoxygenase</subject><subject>Lipoxygenase - analysis</subject><subject>Lipoxygenase Inhibitors - chemistry</subject><subject>Mangifera</subject><subject>Mangifera indica</subject><subject>Picrates - chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFTEQhoMo9lD7E5QFb6qwOvnczZWU4hdUvFBvDdl81JTdpE321G5_vdlzjvXSQEiYPDPvmxmEnmN4gwGLt9-wlLztBOOnmL4SAIK08AhtCOWkZZiJx2jzgByhk1KuoC5KpOzoU3REqICeUrZBP8_iHNp0F6yOc6OjrbsGQvSjniY9p7w02szhNsxLk3wzOu0bdzfnGiw73q_XkGJZn7_oeBm8y7oJ0Qajn6EnXo_FnRzOY_Tjw_vv55_ai68fP5-fXbSGk25uBwrVErOi7y0bqGHeWSKHoYOBdp3srbW4mu-MdlpwTrXr2aAxWA1YdkTSY_R6X_e3jr56UFdpm2NVVEu2y3J_rxwBTIEBhgqf7uHrnG62rsxqCsW4cdTRpW1RmDLOQfY9qyjfoyanUrLz6jqHSedFYVDrKNRuFGrtc81Tu1GoVeLFQWI7TM4-ZP1tfAXe7QFXu3IbXFbFBBeNsyE7Myubwn8lXh6s_Urx8ibUT__zBhSo6CWjfwCeVqQJ</recordid><startdate>20130413</startdate><enddate>20130413</enddate><creator>Mohan, CG</creator><creator>Deepak, M</creator><creator>Viswanatha, GL</creator><creator>Savinay, G</creator><creator>Hanumantharaju, V</creator><creator>Rajendra, CE</creator><creator>Halemani, Praveen D</creator><general>Elsevier B.V</general><general>Department of Pharmacognosy, Government College of Pharmacy, Bangalore-560 027%Department of Phytochemistry, Natural Remedies Pvt. 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Bangalore- 560 100%Department of Pharmacology, PES College of Pharmacy, Bangalore-560050%Deparment of Pharmaceutics, Government College of Pharmacy, Bangalore-560 027%Drug Testing Laboratory, Drugs Control Department, Palace road, Bangalore-560001</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20130413</creationdate><title>Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica</title><author>Mohan, CG ; Deepak, M ; Viswanatha, GL ; Savinay, G ; Hanumantharaju, V ; Rajendra, CE ; Halemani, Praveen D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-b302364d688d4b3c4fed29bb70b37798ddd13297caea6553ae84ba10da0197293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anti-inflammatory</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>assay</topic><topic>Biphenyl Compounds - chemistry</topic><topic>DPPH</topic><topic>DPPH assay</topic><topic>indica</topic><topic>Lipoxygenase</topic><topic>Lipoxygenase - analysis</topic><topic>Lipoxygenase Inhibitors - chemistry</topic><topic>Mangifera</topic><topic>Mangifera indica</topic><topic>Picrates - chemistry</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohan, CG</creatorcontrib><creatorcontrib>Deepak, M</creatorcontrib><creatorcontrib>Viswanatha, GL</creatorcontrib><creatorcontrib>Savinay, G</creatorcontrib><creatorcontrib>Hanumantharaju, V</creatorcontrib><creatorcontrib>Rajendra, CE</creatorcontrib><creatorcontrib>Halemani, Praveen D</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Asian Pacific journal of tropical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohan, CG</au><au>Deepak, M</au><au>Viswanatha, GL</au><au>Savinay, G</au><au>Hanumantharaju, V</au><au>Rajendra, CE</au><au>Halemani, Praveen D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica</atitle><jtitle>Asian Pacific journal of tropical medicine</jtitle><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><date>2013-04-13</date><risdate>2013</risdate><volume>6</volume><issue>4</issue><spage>311</spage><epage>314</epage><pages>311-314</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract>&lt;正&gt;Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract（MEMI）,successive water extract （SWMI） and ethyl acetate fraction（EMEMI）,n-butanol fraction（BMEMI） and water soluble fraction （WMEMI） of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>23608334</pmid><doi>10.1016/S1995-7645(13)60062-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1995-7645 |
| ispartof | Asian Pacific journal of tropical medicine, 2013-04, Vol.6 (4), p.311-314 |
| issn | 1995-7645 2352-4146 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-inflammatory Anti-Inflammatory Agents - chemistry Antioxidants Antioxidants - chemistry assay Biphenyl Compounds - chemistry DPPH DPPH assay indica Lipoxygenase Lipoxygenase - analysis Lipoxygenase Inhibitors - chemistry Mangifera Mangifera indica Picrates - chemistry Plant Extracts - chemistry Plant Leaves |
| title | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica |
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