Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic
<正>Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further co...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2011-11, Vol.4 (11), p.866-869 |
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| creator | Kant Singh, Shashi Sinha, Saurabh K Prasad, SK Kumar, R Bithu, Bhawani S Sadish Kumar, S Singh, P |
| description | <正>Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. |
| doi_str_mv | 10.1016/S1995-7645(11)60210-1 |
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Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.</description><identifier>ISSN: 1995-7645</identifier><identifier>EISSN: 2352-4146</identifier><identifier>DOI: 10.1016/S1995-7645(11)60210-1</identifier><identifier>PMID: 22078948</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>Animals ; Antipyretic ; Bark ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fever - chemically induced ; Fever - drug therapy ; Glycosides - pharmacology ; Glycosides - therapeutic use ; indica ; Mangifera ; Mangifera - chemistry ; Mangifera indica ; Mangiferin ; Mice ; Phytotherapy ; Plant Bark - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Saccharomyces cerevisiae ; Treatment Outcome ; Xanthones - administration & dosage ; Xanthones - chemical synthesis ; Xanthones - pharmacology ; Xanthones - therapeutic use</subject><ispartof>Asian Pacific journal of tropical medicine, 2011-11, Vol.4 (11), p.866-869</ispartof><rights>2011 Hainan Medical College</rights><rights>Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-51464cf92cf21ebf730aad10507e3b016df3aaaea6a50254c5d22b865aa86b463</citedby><cites>FETCH-LOGICAL-c506t-51464cf92cf21ebf730aad10507e3b016df3aaaea6a50254c5d22b865aa86b463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1995-7645(11)60210-1$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22078948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kant Singh, Shashi</creatorcontrib><creatorcontrib>Sinha, Saurabh K</creatorcontrib><creatorcontrib>Prasad, SK</creatorcontrib><creatorcontrib>Kumar, R</creatorcontrib><creatorcontrib>Bithu, Bhawani S</creatorcontrib><creatorcontrib>Sadish Kumar, S</creatorcontrib><creatorcontrib>Singh, P</creatorcontrib><title>Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic</title><title>Asian Pacific journal of tropical medicine</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description>&lt;正&gt;Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.</description><subject>Animals</subject><subject>Antipyretic</subject><subject>Bark</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fever - chemically induced</subject><subject>Fever - drug therapy</subject><subject>Glycosides - pharmacology</subject><subject>Glycosides - therapeutic use</subject><subject>indica</subject><subject>Mangifera</subject><subject>Mangifera - chemistry</subject><subject>Mangifera indica</subject><subject>Mangiferin</subject><subject>Mice</subject><subject>Phytotherapy</subject><subject>Plant Bark - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Saccharomyces cerevisiae</subject><subject>Treatment Outcome</subject><subject>Xanthones - administration & dosage</subject><subject>Xanthones - chemical synthesis</subject><subject>Xanthones - pharmacology</subject><subject>Xanthones - therapeutic use</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaZY0P6HF0EM_wO3o0_YplNAvCOSQ9ixkebRR8Eobyd7i_Ppqs9v0mLkMDM_MvDMvIa8pfKJA1edr2nWybpSQ7yn9oIBRqOkzsmJcslpQoZ6T1SNyQs5yvoUSnHVdw1-SE8agaTvRrsjV9RKmG8w-VyYMFe7MOJvJx1BFV4W4w7HUzRjXM-Z9aWPC2jtMPlQmV9s4YZgKMfntknDy9hV54cyY8eyYT8nvb19_XfyoL6--_7z4cllbCWqqZdEorOuYdYxi7xoOxgwUJDTI-3Li4LgxBo0yEpgUVg6M9a2SxrSqF4qfko-HuX9McEWTvo1zKkKzXtKwLPf3GhnQEgB7-N0B3qZ4Vw6Z9MZni-NoAsY5645x2imqmqdJEEBZK0Qh5YG0Keac0Olt8huTFk1B703SDybpvQOaUv1gkqal781xw9xvcHjs-mdJAc4PAJb37Twmna3HYHHwCe2kh-ifXPH2KO0mhvWdL9_5rw048EY0iv8F_UyshA</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Kant Singh, Shashi</creator><creator>Sinha, Saurabh K</creator><creator>Prasad, SK</creator><creator>Kumar, R</creator><creator>Bithu, Bhawani S</creator><creator>Sadish Kumar, S</creator><creator>Singh, P</creator><general>Elsevier B.V</general><general>Varanasi College of Pharmacy, Uttar Pradesh, Varanasi, India%Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India%Institute of Technology and Sciences, Paramedical College Pharmacy, Muradnagar, Uttar Pradesh, India%Uday Pratap College, Varanasi, Uttar Pradesh, India</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20111101</creationdate><title>Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic</title><author>Kant Singh, Shashi ; Sinha, Saurabh K ; Prasad, SK ; Kumar, R ; Bithu, Bhawani S ; Sadish Kumar, S ; Singh, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-51464cf92cf21ebf730aad10507e3b016df3aaaea6a50254c5d22b865aa86b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antipyretic</topic><topic>Bark</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fever - chemically induced</topic><topic>Fever - drug therapy</topic><topic>Glycosides - pharmacology</topic><topic>Glycosides - therapeutic use</topic><topic>indica</topic><topic>Mangifera</topic><topic>Mangifera - chemistry</topic><topic>Mangifera indica</topic><topic>Mangiferin</topic><topic>Mice</topic><topic>Phytotherapy</topic><topic>Plant Bark - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Saccharomyces cerevisiae</topic><topic>Treatment Outcome</topic><topic>Xanthones - administration & dosage</topic><topic>Xanthones - chemical synthesis</topic><topic>Xanthones - pharmacology</topic><topic>Xanthones - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kant Singh, Shashi</creatorcontrib><creatorcontrib>Sinha, Saurabh K</creatorcontrib><creatorcontrib>Prasad, SK</creatorcontrib><creatorcontrib>Kumar, R</creatorcontrib><creatorcontrib>Bithu, Bhawani S</creatorcontrib><creatorcontrib>Sadish Kumar, S</creatorcontrib><creatorcontrib>Singh, P</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>维普中文医药期刊数据库</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Asian Pacific journal of tropical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kant Singh, Shashi</au><au>Sinha, Saurabh K</au><au>Prasad, SK</au><au>Kumar, R</au><au>Bithu, Bhawani S</au><au>Sadish Kumar, S</au><au>Singh, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic</atitle><jtitle>Asian Pacific journal of tropical medicine</jtitle><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>4</volume><issue>11</issue><spage>866</spage><epage>869</epage><pages>866-869</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract>&lt;正&gt;Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>22078948</pmid><doi>10.1016/S1995-7645(11)60210-1</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1995-7645 |
| ispartof | Asian Pacific journal of tropical medicine, 2011-11, Vol.4 (11), p.866-869 |
| issn | 1995-7645 2352-4146 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
| subjects | Animals Antipyretic Bark Disease Models, Animal Dose-Response Relationship, Drug Fever - chemically induced Fever - drug therapy Glycosides - pharmacology Glycosides - therapeutic use indica Mangifera Mangifera - chemistry Mangifera indica Mangiferin Mice Phytotherapy Plant Bark - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Saccharomyces cerevisiae Treatment Outcome Xanthones - administration & dosage Xanthones - chemical synthesis Xanthones - pharmacology Xanthones - therapeutic use |
| title | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic |
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