丙酮酸激酶M2在胃癌中的作用
R735.2%R730.2; 胃癌是最常见的恶性肿瘤之一,其发病率与死亡率均呈较高水平.丙酮酸激酶M2(pyruvate kinase M2,PKM2)是糖酵解过程的关键限速酶,在多种肿瘤组织中表达明显升高,目前认为PKM2与肿瘤的发生、发展密切相关.在胃癌中,PKM2通过参与调节糖酵解途径、介导PI3K/Akt/mTOR信号通路活化、调控基因转录与细胞凋亡,进而促进胃癌细胞的增殖、转移,抑制细胞凋亡,最终加速胃癌的发展,本文将对此进行详细综述....
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| Veröffentlicht in: | 协和医学杂志 2021, Vol.12 (2), p.227-231 |
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| container_title | 协和医学杂志 |
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| creator | 高洋 孙昭 白春梅 |
| description | R735.2%R730.2; 胃癌是最常见的恶性肿瘤之一,其发病率与死亡率均呈较高水平.丙酮酸激酶M2(pyruvate kinase M2,PKM2)是糖酵解过程的关键限速酶,在多种肿瘤组织中表达明显升高,目前认为PKM2与肿瘤的发生、发展密切相关.在胃癌中,PKM2通过参与调节糖酵解途径、介导PI3K/Akt/mTOR信号通路活化、调控基因转录与细胞凋亡,进而促进胃癌细胞的增殖、转移,抑制细胞凋亡,最终加速胃癌的发展,本文将对此进行详细综述. |
| doi_str_mv | 10.12290/xhyxzz.20190274 |
| format | Article |
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| title | 丙酮酸激酶M2在胃癌中的作用 |
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