Snapshot of HIV pathogenesis in China
ABSTRACT Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China,...
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| Veröffentlicht in: | Cell research 2005-11, Vol.15 (11-12), p.953-961 |
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| container_issue | 11-12 |
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| container_title | Cell research |
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| creator | SAKSENA, Nitin K WANG, Bin STEAIN, Megan YANG, Rong Ge ZHANG, Lin Qi |
| description | ABSTRACT
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area. |
| doi_str_mv | 10.1038/sj.cr.7290373 |
| format | Article |
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Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/sj.cr.7290373</identifier><identifier>PMID: 16354574</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedical and Life Sciences ; Cell Biology ; China ; Disease Outbreaks ; Drug resistance ; Hepatitis ; HIV - genetics ; HIV - pathogenicity ; HIV Infections - epidemiology ; HIV Infections - virology ; Human immunodeficiency virus 1 ; Humans ; Life Sciences ; review ; Vaccines</subject><ispartof>Cell research, 2005-11, Vol.15 (11-12), p.953-961</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2005</rights><rights>Copyright Nature Publishing Group Dec 2005</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-97752e48e912938dc29d35820ee7ae1ecc5cf3e92302a034db49516c81020a5b3</citedby><cites>FETCH-LOGICAL-c480t-97752e48e912938dc29d35820ee7ae1ecc5cf3e92302a034db49516c81020a5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/xbyj/xbyj.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.cr.7290373$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.cr.7290373$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16354574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAKSENA, Nitin K</creatorcontrib><creatorcontrib>WANG, Bin</creatorcontrib><creatorcontrib>STEAIN, Megan</creatorcontrib><creatorcontrib>YANG, Rong Ge</creatorcontrib><creatorcontrib>ZHANG, Lin Qi</creatorcontrib><title>Snapshot of HIV pathogenesis in China</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Res</addtitle><description>ABSTRACT
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>China</subject><subject>Disease Outbreaks</subject><subject>Drug resistance</subject><subject>Hepatitis</subject><subject>HIV - genetics</subject><subject>HIV - pathogenicity</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>review</subject><subject>Vaccines</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0VFr2zAQB3AxNpY23WMfOwyle7N7kixLeiyhbQqBPWztq1CUc2KTyJlk0_bbT8VZN0phTzq4n-4Pd4ScUigocHUZ28KFQjINXPIP5IjKUuVScfUx1QA0hwrYhBzH2AIwUQr6mUxoxVMlyyNy8cPbfdx0fdbV2fzuIdvbftOt0WNsYtb4bLZpvD0hn2q7jfjl8E7J_c31z9k8X3y_vZtdLXJXKuhzLaVgWCrUlGmuVo7pFReKAaK0SNE54WqOmnFgFni5WpZa0MopCgysWPIpuRjnPlpfW782bTcEnxLN0_K5ZQCCJsqT-za6feh-DRh7s2uiw-3WeuyGaCqV1iHSQv4HGVRcC6UTPH8DX6NTolQKZAVJ5aNyoYsxYG32odnZ8JyQeTmHia1xwRzOkfzXw9RhucPVX33YfwLFCGJq-TWGf2Pfn3g2fvC2HwK-TvzT_w17Kpq6</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>SAKSENA, Nitin K</creator><creator>WANG, Bin</creator><creator>STEAIN, Megan</creator><creator>YANG, Rong Ge</creator><creator>ZHANG, Lin Qi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Retroviral Genetics Division, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia%AIDS and HIV Research Group, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China%Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA</general><general>The AIDS Research Center, Chinese Academy of Medical Sciences, Peking Union Medical School, Beijing 100730, China</general><general>Modern Virology Research Center and AIDS Center, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20051101</creationdate><title>Snapshot of HIV pathogenesis in China</title><author>SAKSENA, Nitin K ; 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Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16354574</pmid><doi>10.1038/sj.cr.7290373</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Cell Biology China Disease Outbreaks Drug resistance Hepatitis HIV - genetics HIV - pathogenicity HIV Infections - epidemiology HIV Infections - virology Human immunodeficiency virus 1 Humans Life Sciences review Vaccines |
| title | Snapshot of HIV pathogenesis in China |
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