Following a TRAIL: Update on a ligand and its five receptors
ABSTRACT Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the t...
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| Veröffentlicht in: | Cell research 2004-10, Vol.14 (5), p.359-372 |
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| creator | KIMBERLEY, Fiona C SCREATON, Gavin R |
| description | ABSTRACT
Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves. |
| doi_str_mv | 10.1038/sj.cr.7290236 |
| format | Article |
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Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves.</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/sj.cr.7290236</identifier><identifier>PMID: 15538968</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Apoptosis - drug effects ; Apoptosis - physiology ; Apoptosis Regulatory Proteins ; Biomedical and Life Sciences ; Cell Biology ; Humans ; Life Sciences ; Ligands ; Membrane Glycoproteins - physiology ; Membrane Glycoproteins - therapeutic use ; Models, Biological ; Physiology ; Protein Structure, Tertiary ; Receptors, Tumor Necrosis Factor - physiology ; review ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha - physiology ; Tumor Necrosis Factor-alpha - therapeutic use ; Tumors</subject><ispartof>Cell research, 2004-10, Vol.14 (5), p.359-372</ispartof><rights>Science Press 2004</rights><rights>Copyright Nature Publishing Group Oct 2004</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-108bc813c86b3af0318f3a6a5c816a45cce79dda7f0d6b2d3b60a4e8e8c6758f3</citedby><cites>FETCH-LOGICAL-c515t-108bc813c86b3af0318f3a6a5c816a45cce79dda7f0d6b2d3b60a4e8e8c6758f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/xbyj/xbyj.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.cr.7290236$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.cr.7290236$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27913,27914,41477,42546,51308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15538968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMBERLEY, Fiona C</creatorcontrib><creatorcontrib>SCREATON, Gavin R</creatorcontrib><title>Following a TRAIL: Update on a ligand and its five receptors</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Res</addtitle><description>ABSTRACT
Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. 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Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15538968</pmid><doi>10.1038/sj.cr.7290236</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Animals Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins Biomedical and Life Sciences Cell Biology Humans Life Sciences Ligands Membrane Glycoproteins - physiology Membrane Glycoproteins - therapeutic use Models, Biological Physiology Protein Structure, Tertiary Receptors, Tumor Necrosis Factor - physiology review TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - physiology Tumor Necrosis Factor-alpha - therapeutic use Tumors |
| title | Following a TRAIL: Update on a ligand and its five receptors |
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