Preparation and characterization of PDLLA/chondroitin sulfate /chitosan scaffold for peripheral nerve regeneration
A novel bioactive and bioresorbable PDLLA/chondroitin sulfate/chitosan scaffold was prepared via layer-by-layer(LBL) electrostatic-self-assembly (ESA) and the thermally induced phase separation (TIPS) technique. Chondroitin sulfate and chitosan were alternately deposited on the activated PDLLA subst...
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| Veröffentlicht in: | Journal of Wuhan University of Technology. Materials science edition 2008-04, Vol.23 (2), p.230-233 |
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| container_title | Journal of Wuhan University of Technology. Materials science edition |
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| creator | Xu, Haixing Yan, Yuhua Wan, Tao Li, Shipu |
| description | A novel bioactive and bioresorbable PDLLA/chondroitin sulfate/chitosan scaffold was prepared via layer-by-layer(LBL) electrostatic-self-assembly (ESA) and the thermally induced phase separation (TIPS) technique. Chondroitin sulfate and chitosan were alternately deposited on the activated PDLLA substrate. The deposition process was monitored by UV-Vis absorbance spectroscopy. After frozen and lyophilized, the scaffold was characterized by attenuated total reflection (ATR)-FT-IR, XPS, SEM and AFM. The results showed that the scaffold was modified uniformly with a dense inner layer with few detectable pores and a porous sponge outer layer with the pore size about 5 μm, there was an obvious across section and the average thickness of each layer was about 9.4 nm. |
| doi_str_mv | 10.1007/s11595-006-2230-3 |
| format | Article |
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Chondroitin sulfate and chitosan were alternately deposited on the activated PDLLA substrate. The deposition process was monitored by UV-Vis absorbance spectroscopy. After frozen and lyophilized, the scaffold was characterized by attenuated total reflection (ATR)-FT-IR, XPS, SEM and AFM. The results showed that the scaffold was modified uniformly with a dense inner layer with few detectable pores and a porous sponge outer layer with the pore size about 5 μm, there was an obvious across section and the average thickness of each layer was about 9.4 nm.</description><identifier>ISSN: 1000-2413</identifier><identifier>EISSN: 1993-0437</identifier><identifier>DOI: 10.1007/s11595-006-2230-3</identifier><language>eng</language><publisher>Heidelberg: Wuhan University of Technology</publisher><subject>Arthritis ; Chemistry and Materials Science ; Chondroitin sulfate ; Dietary supplements ; Materials Science</subject><ispartof>Journal of Wuhan University of Technology. 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| ispartof | Journal of Wuhan University of Technology. Materials science edition, 2008-04, Vol.23 (2), p.230-233 |
| issn | 1000-2413 1993-0437 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Arthritis Chemistry and Materials Science Chondroitin sulfate Dietary supplements Materials Science |
| title | Preparation and characterization of PDLLA/chondroitin sulfate /chitosan scaffold for peripheral nerve regeneration |
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