Single Nucleotide Polymorphism of CYP3A4 Intron 2 and Its Influence on CYP3A4 mRNA Expression and Liver Enzymatic Activity in Human Liver

Summary： In adult liver, CYP3A4 plays an important role in the metabolism of a wide range of en- dogenous and exogenous compounds. To investigate whether there is a single nucleotide polymorphism （SNP） of CYP3A4 intron 2 in the liver and its effects on the mRNA expression and enzymatic activity of C...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2015-08, Vol.35 (4), p.502-507
Hauptverfasser:	Huang, Min, Wang, Han-ming, Guo, Yu, Ping, Jie, Chen, Man, Xu, Dan, Wang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asian Continental Ancestry Group - genetics China Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Erythromycin - metabolism Genotype Humans Introns Liver - enzymology Medicine Medicine & Public Health mRNA表达 Phenotype Polymorphism, Single Nucleotide RNA, Messenger - genetics Sequence Analysis, DNA - methods Testosterone - metabolism 内含子单核苷酸多态性单链构象多态性基因组DNA 聚合酶链反应肝脏酶活性
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!