Involvement of VKORC1 in the Inhibition of Calcium Oxalate Crystal Formation in HK-2 Cells

Summary： The vitamin K epoxide reductase complex subunit 1 （VKORC1）, the rate-limiting enzyme for vitamin K recycling, is significantly down-regulated in the kidneys of urolithiasis patients. This study searched for direct evidence to define the inhibitory activity of VKORC1 against calcium oxalate...

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Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2014-06, Vol.34 (3), p.376-381
1. Verfasser:	胡波吴浩然马志永武专昌陆莹梅施国伟
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Blotting, Western Calcium Oxalate - chemistry Calcium Oxalate - metabolism Calcium Oxalate - pharmacology Cell Line Crystallization Dose-Response Relationship, Drug Flow Cytometry Gene Expression Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Medicine Medicine & Public Health Microscopy, Confocal Reverse Transcriptase Polymerase Chain Reaction RNA Interference shRNA Time Factors Transfection Vitamin K Epoxide Reductases - genetics Vitamin K Epoxide Reductases - metabolism Western印迹法实时定量PCR 抑制作用晶体形成激光扫描共聚焦显微镜细胞转染草酸钙晶体
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