Dioscin-induced Apoptosis of Human LNCaP Prostate Carcinoma Cells through Activation of Caspase-3 and Modulation of Bcl-2 Protein Family

Dioscin is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. In the present study, we investigated the anti-cancer activity of dioscin against human LNCaP cells, and evaluated the possible mechanism involved in its antineo...

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Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2014-02, Vol.34 (1), p.125-130
1. Verfasser:	陈静李辉敏张学农熊朝梅阮金兰
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Bax Bcl-2 bcl-2-Associated X Protein - metabolism Bcl-2蛋白 Blotting, Western Caspase 3 - metabolism Caspase-3 Cell Line, Tumor Cell Survival - drug effects Diosgenin - analogs & derivatives Diosgenin - chemistry Diosgenin - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Flow Cytometry Humans LNCaP细胞 Male Medicine Medicine & Public Health Molecular Structure Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Time Factors 前列腺癌细胞细胞凋亡薯蓣皂甙
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