LY294002 Enhances Inhibitory Effect of Gemcitabine on Proliferation of Human Pancreatic Carcinoma PANC-1 Cells

Phosphatidylinositide 3-kinase （PI3K）/protein kinase B （PKB, Akt） pathway plays a major role in proliferation and survival of many types of cells. The inhibitory effect of LY294002, widely ap- plied as an inhibitor of PI3K, in combination with gemcitabine on proliferation of PANC-1 ceils was investi...

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Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2013-02, Vol.33 (1), p.57-62
1. Verfasser:	柯晓煜王渝谢祚启刘志清张翠芳赵秋杨东亮
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimetabolites, Antineoplastic - administration & dosage Cell Proliferation - drug effects Chromones - administration & dosage Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Dose-Response Relationship, Drug Drug Synergism Drug Therapy, Combination - methods Enzyme Inhibitors - administration & dosage Female Humans Male Medicine Medicine & Public Health Middle Aged Morpholines - administration & dosage Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Treatment Outcome Tumor Cells, Cultured Western印迹法抑制作用磷脂酰肌醇细胞增殖胰腺癌胰腺组织蛋白激酶B 蛋白质水平
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