The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China
Summary The relationship between Ala/Ser polymorphism in 133 codon of exon 3 region of the RASSF1 gene and genetic susceptibility of lung cancer in Hubei province Han population was investigated by a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) te...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2009-10, Vol.29 (5), p.646-649 |
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| container_title | Journal of Huazhong University of Science and Technology. Medical sciences |
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| creator | Xiao, Geqiong Zhang, Tao Yao, Jie Ren, Jinghua Cao, Wenmiao Wu, Gang |
| description | Summary
The relationship between Ala/Ser polymorphism in 133 codon of exon 3 region of the RASSF1 gene and genetic susceptibility of lung cancer in Hubei province Han population was investigated by a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was adopted to analyze the polymorphism of codon 133 of exon 3 in the RASSF1 gene of 100 pathologically diagnosed lung cancer patients, and 100 healthy controls. The relationship between different genotypes and the susceptibility of lung cancer was analyzed. Among 200 blood samples from Han people in Hubei Province, including 100 from lung cancer patients and 100 from healthy controls, the frequencies of Ala/Ala, Ala/Ser, Ser/Ser genotype of the RASSF1 in lung cancer patients were 83%, 16%, 1%, and those in healthy controls was 93%, 7%, 0% respectively, with the difference being statistically significant between two groups (
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| doi_str_mv | 10.1007/s11596-009-0522-5 |
| format | Article |
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The relationship between Ala/Ser polymorphism in 133 codon of exon 3 region of the RASSF1 gene and genetic susceptibility of lung cancer in Hubei province Han population was investigated by a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was adopted to analyze the polymorphism of codon 133 of exon 3 in the RASSF1 gene of 100 pathologically diagnosed lung cancer patients, and 100 healthy controls. The relationship between different genotypes and the susceptibility of lung cancer was analyzed. Among 200 blood samples from Han people in Hubei Province, including 100 from lung cancer patients and 100 from healthy controls, the frequencies of Ala/Ala, Ala/Ser, Ser/Ser genotype of the RASSF1 in lung cancer patients were 83%, 16%, 1%, and those in healthy controls was 93%, 7%, 0% respectively, with the difference being statistically significant between two groups (
P
<0.05). The individuals with Ala/Ser genotype had higher risk of suffering from lung cancer, with an OR of 2.341, and 95% CI of 1.009–6.393 respectively. It was concluded that RASSF1Ala133Ser was a susceptible genetic factor of lung cancer. Ala/Ser genotype increased the risk of lung cancer.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/s11596-009-0522-5</identifier><identifier>PMID: 19821102</identifier><language>eng</language><publisher>Heidelberg: Huazhong University of Science and Technology</publisher><subject>Adult ; Case-Control Studies ; China - ethnology ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lung Neoplasms - genetics ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Polymorphism, Genetic ; Risk Factors ; Tumor Suppressor Proteins - genetics</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2009-10, Vol.29 (5), p.646-649</ispartof><rights>Huazhong University of Science and Technology and Springer Berlin Heidelberg 2009</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-f0ed8fe27e8b672415f8ae26040a95abc68df591f5eee9da872b2db6123e5c023</citedby><cites>FETCH-LOGICAL-c411t-f0ed8fe27e8b672415f8ae26040a95abc68df591f5eee9da872b2db6123e5c023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/tjykdxxb-e/tjykdxxb-e.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19821102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Geqiong</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Yao, Jie</creatorcontrib><creatorcontrib>Ren, Jinghua</creatorcontrib><creatorcontrib>Cao, Wenmiao</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><title>The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>J. Huazhong Univ. Sci. Technol. [Med. Sci.]</addtitle><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><description>Summary
The relationship between Ala/Ser polymorphism in 133 codon of exon 3 region of the RASSF1 gene and genetic susceptibility of lung cancer in Hubei province Han population was investigated by a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was adopted to analyze the polymorphism of codon 133 of exon 3 in the RASSF1 gene of 100 pathologically diagnosed lung cancer patients, and 100 healthy controls. The relationship between different genotypes and the susceptibility of lung cancer was analyzed. Among 200 blood samples from Han people in Hubei Province, including 100 from lung cancer patients and 100 from healthy controls, the frequencies of Ala/Ala, Ala/Ser, Ser/Ser genotype of the RASSF1 in lung cancer patients were 83%, 16%, 1%, and those in healthy controls was 93%, 7%, 0% respectively, with the difference being statistically significant between two groups (
P
<0.05). The individuals with Ala/Ser genotype had higher risk of suffering from lung cancer, with an OR of 2.341, and 95% CI of 1.009–6.393 respectively. It was concluded that RASSF1Ala133Ser was a susceptible genetic factor of lung cancer. Ala/Ser genotype increased the risk of lung cancer.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>China - ethnology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Tumor Suppressor Proteins - genetics</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EoqXwA7gg3zigwNiJk_hYrShFqgSi5WzZyXjXS2IHO6G7_x6vslJPiNNYmm_e-M0j5C2Djwyg-ZQYE7IuAGQBgvNCPCOXTMqyYKXgz_O7bngBTVlekFcp7QFEU_PqJblgsuWMAb8kh4cdUp1S6JyeXfDU4PyI6OmP6_v7G0a36JFOYTiOIU47l8ZEte_psPgt7bTvMNK0pA6n2Rk3uPlI9Rhyb8IwDUidp7eLQUe_x_DHZZwGSzc75_Vr8sLqIeGbc70iP28-P2xui7tvX75uru-KrmJsLixg31rkDbYmu6mYsK1GXkMFWgpturrtrZDMCkSUvW4bbnhvasZLFB3w8op8WHUftbfab9U-LNHnjWreH3_1h4NRyPMFQQA_0e9Xeorh94JpVqPL7oZBewxLUk0lZD6jqP5PlhW00FZlJtlKdjGkFNGqKbpRx6NioE45qjVHlX-hTjkqkWfendUXM2L_NHEOLgN8BVJu-S3GJ1__Vv0LlbOpPQ</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Xiao, Geqiong</creator><creator>Zhang, Tao</creator><creator>Yao, Jie</creator><creator>Ren, Jinghua</creator><creator>Cao, Wenmiao</creator><creator>Wu, Gang</creator><general>Huazhong University of Science and Technology</general><general>Cancer Center, Union Hospital Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430023, China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20091001</creationdate><title>The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China</title><author>Xiao, Geqiong ; Zhang, Tao ; Yao, Jie ; Ren, Jinghua ; Cao, Wenmiao ; Wu, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-f0ed8fe27e8b672415f8ae26040a95abc68df591f5eee9da872b2db6123e5c023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>China - ethnology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Tumor Suppressor Proteins - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Geqiong</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Yao, Jie</creatorcontrib><creatorcontrib>Ren, Jinghua</creatorcontrib><creatorcontrib>Cao, Wenmiao</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Geqiong</au><au>Zhang, Tao</au><au>Yao, Jie</au><au>Ren, Jinghua</au><au>Cao, Wenmiao</au><au>Wu, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><stitle>J. Huazhong Univ. Sci. Technol. [Med. Sci.]</stitle><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>29</volume><issue>5</issue><spage>646</spage><epage>649</epage><pages>646-649</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>Summary
The relationship between Ala/Ser polymorphism in 133 codon of exon 3 region of the RASSF1 gene and genetic susceptibility of lung cancer in Hubei province Han population was investigated by a case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was adopted to analyze the polymorphism of codon 133 of exon 3 in the RASSF1 gene of 100 pathologically diagnosed lung cancer patients, and 100 healthy controls. The relationship between different genotypes and the susceptibility of lung cancer was analyzed. Among 200 blood samples from Han people in Hubei Province, including 100 from lung cancer patients and 100 from healthy controls, the frequencies of Ala/Ala, Ala/Ser, Ser/Ser genotype of the RASSF1 in lung cancer patients were 83%, 16%, 1%, and those in healthy controls was 93%, 7%, 0% respectively, with the difference being statistically significant between two groups (
P
<0.05). The individuals with Ala/Ser genotype had higher risk of suffering from lung cancer, with an OR of 2.341, and 95% CI of 1.009–6.393 respectively. It was concluded that RASSF1Ala133Ser was a susceptible genetic factor of lung cancer. Ala/Ser genotype increased the risk of lung cancer.</abstract><cop>Heidelberg</cop><pub>Huazhong University of Science and Technology</pub><pmid>19821102</pmid><doi>10.1007/s11596-009-0522-5</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Case-Control Studies China - ethnology Female Genetic Predisposition to Disease Genotype Humans Lung Neoplasms - genetics Male Medicine Medicine & Public Health Middle Aged Polymorphism, Genetic Risk Factors Tumor Suppressor Proteins - genetics |
| title | The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China |
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