The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris
In order to study the expression of interleukin-22 （IL-22） and S 100A7, A8, A9 mRNA in the skin lesions of patients with psoriasis vulgaris and their relationship, the biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, and the expression...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2007-10, Vol.27 (5), p.605-607 |
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| container_title | Journal of Huazhong University of Science and Technology. Medical sciences |
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| creator | 刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭 |
| description | In order to study the expression of interleukin-22 （IL-22） and S 100A7, A8, A9 mRNA in the skin lesions of patients with psoriasis vulgaris and their relationship, the biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, and the expression levels of 1L-22 and S 100A7, A8 and A9 mRNA were detected by semi-quantitative RT-PCR. The results showed that （1） IL-22 and S 100A8, A9 mRNA were positively expressed in the psoriatic skin lesions but negatively expressed in the normal controls; The expression level of S 100A7 was （1.133±0.040） in the psoriatic skin lesions, significantly higher than that in the normal controls （0.744±0.037, P〈0.01）. （2） There were significantly positive correlations between the expression of IL-22/S100A7 mRNA, IL-22/S100A8 mRNA, IL-22/S100A9 mRNA in the psoriasis vulgaris （r1=-0.543, r2=0.774, r3=0.621, P〈0.01）. It was concluded that IL-22 and S 100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis. |
| doi_str_mv | 10.1007/s11596-007-0533-z |
| format | Article |
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The results showed that （1） IL-22 and S 100A8, A9 mRNA were positively expressed in the psoriatic skin lesions but negatively expressed in the normal controls; The expression level of S 100A7 was （1.133±0.040） in the psoriatic skin lesions, significantly higher than that in the normal controls （0.744±0.037, P〈0.01）. （2） There were significantly positive correlations between the expression of IL-22/S100A7 mRNA, IL-22/S100A8 mRNA, IL-22/S100A9 mRNA in the psoriasis vulgaris （r1=-0.543, r2=0.774, r3=0.621, P〈0.01）. It was concluded that IL-22 and S 100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/s11596-007-0533-z</identifier><identifier>PMID: 18060647</identifier><language>eng</language><publisher>China: Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</publisher><subject>Adolescent ; Adult ; Aged ; Calgranulin A - genetics ; Calgranulin A - metabolism ; Calgranulin B - genetics ; Calgranulin B - metabolism ; Female ; Humans ; Interleukin-22 ; Interleukins - genetics ; Interleukins - metabolism ; Male ; Middle Aged ; Psoriasis - metabolism ; Psoriasis - pathology ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; S100 Calcium Binding Protein A7 ; S100 Proteins - genetics ; S100 Proteins - metabolism ; Skin - metabolism ; Young Adult ; 内白细胞素-22 ; 基因表达 ; 牛皮癣 ; 皮肤病</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2007-10, Vol.27 (5), p.605-607</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-b46fdfe76ea096ea232d67174d397f9fee7c0855b5b1587eab473fda5687fbca3</citedby><cites>FETCH-LOGICAL-c394t-b46fdfe76ea096ea232d67174d397f9fee7c0855b5b1587eab473fda5687fbca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18060647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭</creatorcontrib><title>The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description>In order to study the expression of interleukin-22 （IL-22） and S 100A7, A8, A9 mRNA in the skin lesions of patients with psoriasis vulgaris and their relationship, the biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, and the expression levels of 1L-22 and S 100A7, A8 and A9 mRNA were detected by semi-quantitative RT-PCR. The results showed that （1） IL-22 and S 100A8, A9 mRNA were positively expressed in the psoriatic skin lesions but negatively expressed in the normal controls; The expression level of S 100A7 was （1.133±0.040） in the psoriatic skin lesions, significantly higher than that in the normal controls （0.744±0.037, P〈0.01）. （2） There were significantly positive correlations between the expression of IL-22/S100A7 mRNA, IL-22/S100A8 mRNA, IL-22/S100A9 mRNA in the psoriasis vulgaris （r1=-0.543, r2=0.774, r3=0.621, P〈0.01）. It was concluded that IL-22 and S 100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Calgranulin A - genetics</subject><subject>Calgranulin A - metabolism</subject><subject>Calgranulin B - genetics</subject><subject>Calgranulin B - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-22</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psoriasis - metabolism</subject><subject>Psoriasis - pathology</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>S100 Calcium Binding Protein A7</subject><subject>S100 Proteins - genetics</subject><subject>S100 Proteins - metabolism</subject><subject>Skin - metabolism</subject><subject>Young Adult</subject><subject>内白细胞素-22</subject><subject>基因表达</subject><subject>牛皮癣</subject><subject>皮肤病</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EoqXlA3BBFodygAX_9_oYVQUqVaUqhROS5d0dJ0423tTeVdN-ehwlErcePH6H37zRzEPoHSVfKCH6a6ZUGlUVWRHJefX0Ah1TY3hFuWQvi1aaVURzfoTe5LwkRGrFxGt0RGuiiBL6GP29WwC-2G4S5ByGiAePL-MIqYdpFWLFGHaxw7_KuJn-jGd1eQavb69nOER848YAccz4IYwLfJOHFFwOGf-Z-rlLIZ-iV971Gd4e_hP0-9vF3fmP6urn98vz2VXVciPGqhHKdx60AkdMKYyzTmmqRceN9sYD6JbUUjayobLW4Bqhue-cVLX2Tev4Cfq0931w0bs4t8thSrFMtOPycdVtt40FVq5EJOG80B_39CYN9xPk0a5DbqHvXYRhylZzwZgwkhby7FmSEWU0E6KAdA-2acg5gbebFNYuPVpK7C4qu4_K7uQuKvtUet4fzKdmDd3_jkM2BfhwMF0McX4fyl6Na1c-9GBZASgXhv8DRfKYEw</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭</creator><general>Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20071001</creationdate><title>The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris</title><author>刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-b46fdfe76ea096ea232d67174d397f9fee7c0855b5b1587eab473fda5687fbca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Calgranulin A - genetics</topic><topic>Calgranulin A - metabolism</topic><topic>Calgranulin B - genetics</topic><topic>Calgranulin B - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-22</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psoriasis - metabolism</topic><topic>Psoriasis - pathology</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>S100 Calcium Binding Protein A7</topic><topic>S100 Proteins - genetics</topic><topic>S100 Proteins - metabolism</topic><topic>Skin - metabolism</topic><topic>Young Adult</topic><topic>内白细胞素-22</topic><topic>基因表达</topic><topic>牛皮癣</topic><topic>皮肤病</topic><toplevel>online_resources</toplevel><creatorcontrib>刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>刘厚君 黄琨 吴艳 林能兴 李家文 涂亚庭</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>27</volume><issue>5</issue><spage>605</spage><epage>607</epage><pages>605-607</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>In order to study the expression of interleukin-22 （IL-22） and S 100A7, A8, A9 mRNA in the skin lesions of patients with psoriasis vulgaris and their relationship, the biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, and the expression levels of 1L-22 and S 100A7, A8 and A9 mRNA were detected by semi-quantitative RT-PCR. The results showed that （1） IL-22 and S 100A8, A9 mRNA were positively expressed in the psoriatic skin lesions but negatively expressed in the normal controls; The expression level of S 100A7 was （1.133±0.040） in the psoriatic skin lesions, significantly higher than that in the normal controls （0.744±0.037, P〈0.01）. （2） There were significantly positive correlations between the expression of IL-22/S100A7 mRNA, IL-22/S100A8 mRNA, IL-22/S100A9 mRNA in the psoriasis vulgaris （r1=-0.543, r2=0.774, r3=0.621, P〈0.01）. It was concluded that IL-22 and S 100A7, A8, A9 might play important roles in the occurrence and progression of psoriasis.</abstract><cop>China</cop><pub>Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</pub><pmid>18060647</pmid><doi>10.1007/s11596-007-0533-z</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1672-0733 |
| ispartof | Journal of Huazhong University of Science and Technology. Medical sciences, 2007-10, Vol.27 (5), p.605-607 |
| issn | 1672-0733 1993-1352 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Calgranulin A - genetics Calgranulin A - metabolism Calgranulin B - genetics Calgranulin B - metabolism Female Humans Interleukin-22 Interleukins - genetics Interleukins - metabolism Male Middle Aged Psoriasis - metabolism Psoriasis - pathology RNA, Messenger - genetics RNA, Messenger - metabolism S100 Calcium Binding Protein A7 S100 Proteins - genetics S100 Proteins - metabolism Skin - metabolism Young Adult 内白细胞素-22 基因表达 牛皮癣 皮肤病 |
| title | The Expression of Interleukin-22 and S100A7, A8, A9 mRNA in Patients with Psoriasis Vulgaris |
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