Influence of Transplantation of Allogenic Bone Marrow Mononuclear Cells on the Left Ventricular Remodeling of Rat after Acute Myocardial Infarction
To probe into the influence of transplantation of allogenic bone marrow mononuclear cells （BM-MNCs） on the left ventricular remodeling of rat after acute myocardial infarction （AMI）, 60 male Wistar rats were evenly divided into three groups at random： control group 1, control group 2 and transplanta...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2006, Vol.26 (6), p.696-699 |
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| creator | 张瑞成 董念国 侯剑峰 法宪恩 |
| description | To probe into the influence of transplantation of allogenic bone marrow mononuclear cells （BM-MNCs） on the left ventricular remodeling of rat after acute myocardial infarction （AMI）, 60 male Wistar rats were evenly divided into three groups at random： control group 1, control group 2 and transplantation group. In control group 1, chest was opened without ligation of coronary artery; in control group 2 and transplantation group, the left anterior descending branch of coronary artery was ligated to establish AMI model. Prepared culture medium and allogenic BM-MNCs suspension were respectively implanted the surrounding area of infracted cardiac muscle via epicardium of control group 2 and transplantation group. Four weeks after the operation, the osteopontin gene （OPN mRNA, P〈0.01）, type Ⅰ collagen （P〈0.01） and angiotensin Ⅱ （AngⅡ, P〈0.01） content in the left ventricular non-infracted myocardium, and the Ang Ⅱ density in blood plasma （P〈0.05） of transplantation group and control group 2 were all significantly higher than that of control group Ⅰ. In the transplantation group, the myocardial OPN InRNA, type Ⅰ collagen and Ang Ⅱ content of non-infracted zone in left ventricle, and the Ang Ⅱ concentration in blood plasma were all significantly lower than those of control group 2 （P〈0.05 for all）. It is concluded that allogenic BM-MNCs transplantation may ease left ventricular remodeling after AMI by inhibiting the synthesis of type Ⅰ collagen in the cardiac muscle and down-regulating the expression of Ang Ⅱ and OPN gene. |
| doi_str_mv | 10.1007/s11596-006-0618-0 |
| format | Article |
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In control group 1, chest was opened without ligation of coronary artery; in control group 2 and transplantation group, the left anterior descending branch of coronary artery was ligated to establish AMI model. Prepared culture medium and allogenic BM-MNCs suspension were respectively implanted the surrounding area of infracted cardiac muscle via epicardium of control group 2 and transplantation group. Four weeks after the operation, the osteopontin gene （OPN mRNA, P〈0.01）, type Ⅰ collagen （P〈0.01） and angiotensin Ⅱ （AngⅡ, P〈0.01） content in the left ventricular non-infracted myocardium, and the Ang Ⅱ density in blood plasma （P〈0.05） of transplantation group and control group 2 were all significantly higher than that of control group Ⅰ. In the transplantation group, the myocardial OPN InRNA, type Ⅰ collagen and Ang Ⅱ content of non-infracted zone in left ventricle, and the Ang Ⅱ concentration in blood plasma were all significantly lower than those of control group 2 （P〈0.05 for all）. It is concluded that allogenic BM-MNCs transplantation may ease left ventricular remodeling after AMI by inhibiting the synthesis of type Ⅰ collagen in the cardiac muscle and down-regulating the expression of Ang Ⅱ and OPN gene.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/s11596-006-0618-0</identifier><identifier>PMID: 17357492</identifier><language>eng</language><publisher>China: Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China%Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China%Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China</publisher><subject>Angiotensin II - blood ; Angiotensin II - metabolism ; Animals ; Bone Marrow Transplantation ; Collagen Type I - biosynthesis ; Disease Models, Animal ; Leukocytes, Mononuclear - transplantation ; Male ; Myocardial Infarction - surgery ; Osteopontin - metabolism ; Rats ; Rats, Wistar ; Ventricular Remodeling ; 单核细胞 ; 心室功能 ; 心肌疾病 ; 骨髓移植</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2006, Vol.26 (6), p.696-699</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2618-33778d7e6b153aeadb2c8d07133e61354032415ddddc97b76d2f7ee889a035d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17357492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>张瑞成 董念国 侯剑峰 法宪恩</creatorcontrib><title>Influence of Transplantation of Allogenic Bone Marrow Mononuclear Cells on the Left Ventricular Remodeling of Rat after Acute Myocardial Infarction</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description>To probe into the influence of transplantation of allogenic bone marrow mononuclear cells （BM-MNCs） on the left ventricular remodeling of rat after acute myocardial infarction （AMI）, 60 male Wistar rats were evenly divided into three groups at random： control group 1, control group 2 and transplantation group. In control group 1, chest was opened without ligation of coronary artery; in control group 2 and transplantation group, the left anterior descending branch of coronary artery was ligated to establish AMI model. Prepared culture medium and allogenic BM-MNCs suspension were respectively implanted the surrounding area of infracted cardiac muscle via epicardium of control group 2 and transplantation group. Four weeks after the operation, the osteopontin gene （OPN mRNA, P〈0.01）, type Ⅰ collagen （P〈0.01） and angiotensin Ⅱ （AngⅡ, P〈0.01） content in the left ventricular non-infracted myocardium, and the Ang Ⅱ density in blood plasma （P〈0.05） of transplantation group and control group 2 were all significantly higher than that of control group Ⅰ. In the transplantation group, the myocardial OPN InRNA, type Ⅰ collagen and Ang Ⅱ content of non-infracted zone in left ventricle, and the Ang Ⅱ concentration in blood plasma were all significantly lower than those of control group 2 （P〈0.05 for all）. It is concluded that allogenic BM-MNCs transplantation may ease left ventricular remodeling after AMI by inhibiting the synthesis of type Ⅰ collagen in the cardiac muscle and down-regulating the expression of Ang Ⅱ and OPN gene.</description><subject>Angiotensin II - blood</subject><subject>Angiotensin II - metabolism</subject><subject>Animals</subject><subject>Bone Marrow Transplantation</subject><subject>Collagen Type I - biosynthesis</subject><subject>Disease Models, Animal</subject><subject>Leukocytes, Mononuclear - transplantation</subject><subject>Male</subject><subject>Myocardial Infarction - surgery</subject><subject>Osteopontin - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Ventricular Remodeling</subject><subject>单核细胞</subject><subject>心室功能</subject><subject>心肌疾病</subject><subject>骨髓移植</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu3CAUhq2qVZOmfYBuKtRFu6jccDEGLyejXiJNFClKu0UYjieeMDABrGSeoy9crBkpu4AQCL7zn8P5q-ojwd8JxuI8EcK7tsa4rJbIGr-qTknXsZowTl-XcytojQVjJ9W7lDYYc9HS5m11QgTjounoafXv0g9uAm8AhQHdRu3TzmmfdR6Dn68WzoU1-NGgi-ABXekYwyO6Cj74yTjQES3BuYQKne8ArWDI6C_4HEczufJ6A9tgwY1-Pavd6Iz0kCGihZlykdsHo6MdtUOlEB3NnPZ99WbQLsGH435W_fn543b5u15d_7pcLla1ofNvGRNCWgFtTzjToG1PjbRYEMagLR1oMKMN4bYM04letJYOAkDKTmPGLWdn1beD7qMuuf1abcIUfcmo8mZ_b5-eegW0NLdMIgv99UDvYniYIGW1HZMpf9cewpSUYA2RVNKmkF9eJEnXNpRRXEByAE0MKUUY1C6OWx33imA1O6wODqtShJodVnPMp6P41G_BPkccLS3A56PoXfDrh9J41WtzP4wOFGVtIwWX7D8Np63H</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>张瑞成 董念国 侯剑峰 法宪恩</creator><general>Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China%Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China%Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China</general><general>Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2006</creationdate><title>Influence of Transplantation of Allogenic Bone Marrow Mononuclear Cells on the Left Ventricular Remodeling of Rat after Acute Myocardial Infarction</title><author>张瑞成 董念国 侯剑峰 法宪恩</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2618-33778d7e6b153aeadb2c8d07133e61354032415ddddc97b76d2f7ee889a035d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Angiotensin II - blood</topic><topic>Angiotensin II - metabolism</topic><topic>Animals</topic><topic>Bone Marrow Transplantation</topic><topic>Collagen Type I - biosynthesis</topic><topic>Disease Models, Animal</topic><topic>Leukocytes, Mononuclear - transplantation</topic><topic>Male</topic><topic>Myocardial Infarction - surgery</topic><topic>Osteopontin - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Ventricular Remodeling</topic><topic>单核细胞</topic><topic>心室功能</topic><topic>心肌疾病</topic><topic>骨髓移植</topic><toplevel>online_resources</toplevel><creatorcontrib>张瑞成 董念国 侯剑峰 法宪恩</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>张瑞成 董念国 侯剑峰 法宪恩</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Transplantation of Allogenic Bone Marrow Mononuclear Cells on the Left Ventricular Remodeling of Rat after Acute Myocardial Infarction</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2006</date><risdate>2006</risdate><volume>26</volume><issue>6</issue><spage>696</spage><epage>699</epage><pages>696-699</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>To probe into the influence of transplantation of allogenic bone marrow mononuclear cells （BM-MNCs） on the left ventricular remodeling of rat after acute myocardial infarction （AMI）, 60 male Wistar rats were evenly divided into three groups at random： control group 1, control group 2 and transplantation group. In control group 1, chest was opened without ligation of coronary artery; in control group 2 and transplantation group, the left anterior descending branch of coronary artery was ligated to establish AMI model. Prepared culture medium and allogenic BM-MNCs suspension were respectively implanted the surrounding area of infracted cardiac muscle via epicardium of control group 2 and transplantation group. Four weeks after the operation, the osteopontin gene （OPN mRNA, P〈0.01）, type Ⅰ collagen （P〈0.01） and angiotensin Ⅱ （AngⅡ, P〈0.01） content in the left ventricular non-infracted myocardium, and the Ang Ⅱ density in blood plasma （P〈0.05） of transplantation group and control group 2 were all significantly higher than that of control group Ⅰ. In the transplantation group, the myocardial OPN InRNA, type Ⅰ collagen and Ang Ⅱ content of non-infracted zone in left ventricle, and the Ang Ⅱ concentration in blood plasma were all significantly lower than those of control group 2 （P〈0.05 for all）. It is concluded that allogenic BM-MNCs transplantation may ease left ventricular remodeling after AMI by inhibiting the synthesis of type Ⅰ collagen in the cardiac muscle and down-regulating the expression of Ang Ⅱ and OPN gene.</abstract><cop>China</cop><pub>Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China%Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China%Department of Cardiovascular Surgery, No.2 Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China</pub><pmid>17357492</pmid><doi>10.1007/s11596-006-0618-0</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1672-0733 |
| ispartof | Journal of Huazhong University of Science and Technology. Medical sciences, 2006, Vol.26 (6), p.696-699 |
| issn | 1672-0733 1993-1352 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Angiotensin II - blood Angiotensin II - metabolism Animals Bone Marrow Transplantation Collagen Type I - biosynthesis Disease Models, Animal Leukocytes, Mononuclear - transplantation Male Myocardial Infarction - surgery Osteopontin - metabolism Rats Rats, Wistar Ventricular Remodeling 单核细胞 心室功能 心肌疾病 骨髓移植 |
| title | Influence of Transplantation of Allogenic Bone Marrow Mononuclear Cells on the Left Ventricular Remodeling of Rat after Acute Myocardial Infarction |
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