A study on the traditional Chinese medicine Jinyebaidu for prevention and treatment of intrauterine infection with guinea pigs cytomegalovirus
The purpose is to study the prophylactic and therapeutic effect of the traditional Chinese Medicine (TCM)-Jinyebaidu (JYBD) to guinea pig cytomegalovirus (GPCMV) intrauterine infection. The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2005, Vol.25 (6), p.721-723 |
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| container_title | Journal of Huazhong University of Science and Technology. Medical sciences |
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| creator | Chen, Suhua Xiong, Jinwen Xing, Wei Wen, Liangzhen Liu, Haizhi Wang, Xinrong |
| description | The purpose is to study the prophylactic and therapeutic effect of the traditional Chinese Medicine (TCM)-Jinyebaidu (JYBD) to guinea pig cytomegalovirus (GPCMV) intrauterine infection. The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred, pregnant guinea pigs were selected and divided into 3 groups randomly: 5 guniea pigs of the blank control group were not given either GPCMV or JYBD. 31 guniea pigs of the positive control group were inoculated 1 mL (10(7) TCID50) suspension of GPCMV intraperitoneal. 10 guniea pigs of the experimental group were inoculated GPCMV firstly and then perfused stomach with JYBD for 14 days (Dosage in accordance with the modulus of the weight ratio of human to guniea pig). The effects of JYBD on the intrauterine infection of GPCMV were observed. The results showed that JYBD could decrease the maternal infection rate from 100% (31/31) to 50% (5/10) (P < 0.001), the intrauterine infection rate from 100% (72/72) to 75% (21/28) (P < 0.001), and the rate of abnormal outcome of pregnancy from 64.4% (29/45) to 25.0% (7/28) (P < 0.001), the infective symptoms being relieved. It can be concluded that traditional Chinese medicine- JYBD can prevent and treat (GPCMV intrauterine infection, and can be expected a prophylactic drug for HCMV intrauterine infection. |
| doi_str_mv | 10.1007/bf02896182 |
| format | Article |
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The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred, pregnant guinea pigs were selected and divided into 3 groups randomly: 5 guniea pigs of the blank control group were not given either GPCMV or JYBD. 31 guniea pigs of the positive control group were inoculated 1 mL (10(7) TCID50) suspension of GPCMV intraperitoneal. 10 guniea pigs of the experimental group were inoculated GPCMV firstly and then perfused stomach with JYBD for 14 days (Dosage in accordance with the modulus of the weight ratio of human to guniea pig). The effects of JYBD on the intrauterine infection of GPCMV were observed. The results showed that JYBD could decrease the maternal infection rate from 100% (31/31) to 50% (5/10) (P < 0.001), the intrauterine infection rate from 100% (72/72) to 75% (21/28) (P < 0.001), and the rate of abnormal outcome of pregnancy from 64.4% (29/45) to 25.0% (7/28) (P < 0.001), the infective symptoms being relieved. It can be concluded that traditional Chinese medicine- JYBD can prevent and treat (GPCMV intrauterine infection, and can be expected a prophylactic drug for HCMV intrauterine infection.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/bf02896182</identifier><identifier>PMID: 16696337</identifier><language>eng</language><publisher>China: Department of obstetrics & gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China</publisher><subject>Animals ; Cytomegalovirus ; Cytomegalovirus Infections - drug therapy ; Drugs, Chinese Herbal - therapeutic use ; Female ; Fetal Diseases - drug therapy ; Fetal Diseases - prevention & control ; Fetal Diseases - virology ; Guinea pig cytomegalovirus ; Guinea Pigs ; Human cytomegalovirus ; Male ; Phytotherapy ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Random Allocation</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2005, Vol.25 (6), p.721-723</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2672-3e28627ad7e930e61e79fa5858df9485084c49e62e9d87dee7725ebff63293b63</citedby><cites>FETCH-LOGICAL-c2672-3e28627ad7e930e61e79fa5858df9485084c49e62e9d87dee7725ebff63293b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/tjykdxxb-e/tjykdxxb-e.jpg</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16696337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Suhua</creatorcontrib><creatorcontrib>Xiong, Jinwen</creatorcontrib><creatorcontrib>Xing, Wei</creatorcontrib><creatorcontrib>Wen, Liangzhen</creatorcontrib><creatorcontrib>Liu, Haizhi</creatorcontrib><creatorcontrib>Wang, Xinrong</creatorcontrib><title>A study on the traditional Chinese medicine Jinyebaidu for prevention and treatment of intrauterine infection with guinea pigs cytomegalovirus</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><description>The purpose is to study the prophylactic and therapeutic effect of the traditional Chinese Medicine (TCM)-Jinyebaidu (JYBD) to guinea pig cytomegalovirus (GPCMV) intrauterine infection. The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred, pregnant guinea pigs were selected and divided into 3 groups randomly: 5 guniea pigs of the blank control group were not given either GPCMV or JYBD. 31 guniea pigs of the positive control group were inoculated 1 mL (10(7) TCID50) suspension of GPCMV intraperitoneal. 10 guniea pigs of the experimental group were inoculated GPCMV firstly and then perfused stomach with JYBD for 14 days (Dosage in accordance with the modulus of the weight ratio of human to guniea pig). The effects of JYBD on the intrauterine infection of GPCMV were observed. The results showed that JYBD could decrease the maternal infection rate from 100% (31/31) to 50% (5/10) (P < 0.001), the intrauterine infection rate from 100% (72/72) to 75% (21/28) (P < 0.001), and the rate of abnormal outcome of pregnancy from 64.4% (29/45) to 25.0% (7/28) (P < 0.001), the infective symptoms being relieved. It can be concluded that traditional Chinese medicine- JYBD can prevent and treat (GPCMV intrauterine infection, and can be expected a prophylactic drug for HCMV intrauterine infection.</description><subject>Animals</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Fetal Diseases - drug therapy</subject><subject>Fetal Diseases - prevention & control</subject><subject>Fetal Diseases - virology</subject><subject>Guinea pig cytomegalovirus</subject><subject>Guinea Pigs</subject><subject>Human cytomegalovirus</subject><subject>Male</subject><subject>Phytotherapy</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Random Allocation</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uFDEQhC0EIj9w4QGQTxxAC_4Z2-NjsiIBFIkLnEeecXvXy4y92J4k8xI8M152EUdO3Sp9XVJ1IfSKkveUEPWhd4S1WtKWPUHnVGu-olywp3WXiq2I4vwMXeS8I0QoyZrn6IxKqSXn6hz9usK5zHbBMeCyBVySsb74GMyI11sfIAOewPqhrviLDwv0xtsZu5jwPsE9hAOMTbD1FEyZqoCjwz5Up7lAOtz54GD4wz34ssWbuYoG7_0m42EpcYKNGeO9T3N-gZ45M2Z4eZqX6PvNx2_rT6u7r7ef11d3q4EdMnFgrWTKWAWaE5AUlHZGtKK1TjetIG0zNBokA21bZQGUYgJ65yRnmveSX6J3R98HE5wJm24X51Qz567slh_28bHvgNV_EUk4q_SbI71P8ecMuXSTzwOMowkQ59wpQmWjtPovSLUQjW5EBd8ewSHFnBO4bp_8ZNLSUdIdSu2ub_6WWuHXJ9e5r138Q08t8t_5pZ8B</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Chen, Suhua</creator><creator>Xiong, Jinwen</creator><creator>Xing, Wei</creator><creator>Wen, Liangzhen</creator><creator>Liu, Haizhi</creator><creator>Wang, Xinrong</creator><general>Department of obstetrics & gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>A study on the traditional Chinese medicine Jinyebaidu for prevention and treatment of intrauterine infection with guinea pigs cytomegalovirus</title><author>Chen, Suhua ; Xiong, Jinwen ; Xing, Wei ; Wen, Liangzhen ; Liu, Haizhi ; Wang, Xinrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2672-3e28627ad7e930e61e79fa5858df9485084c49e62e9d87dee7725ebff63293b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>Fetal Diseases - drug therapy</topic><topic>Fetal Diseases - prevention & control</topic><topic>Fetal Diseases - virology</topic><topic>Guinea pig cytomegalovirus</topic><topic>Guinea Pigs</topic><topic>Human cytomegalovirus</topic><topic>Male</topic><topic>Phytotherapy</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Random Allocation</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Suhua</creatorcontrib><creatorcontrib>Xiong, Jinwen</creatorcontrib><creatorcontrib>Xing, Wei</creatorcontrib><creatorcontrib>Wen, Liangzhen</creatorcontrib><creatorcontrib>Liu, Haizhi</creatorcontrib><creatorcontrib>Wang, Xinrong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Suhua</au><au>Xiong, Jinwen</au><au>Xing, Wei</au><au>Wen, Liangzhen</au><au>Liu, Haizhi</au><au>Wang, Xinrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study on the traditional Chinese medicine Jinyebaidu for prevention and treatment of intrauterine infection with guinea pigs cytomegalovirus</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><addtitle>J Huazhong Univ Sci Technolog Med Sci</addtitle><date>2005</date><risdate>2005</risdate><volume>25</volume><issue>6</issue><spage>721</spage><epage>723</epage><pages>721-723</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>The purpose is to study the prophylactic and therapeutic effect of the traditional Chinese Medicine (TCM)-Jinyebaidu (JYBD) to guinea pig cytomegalovirus (GPCMV) intrauterine infection. The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred, pregnant guinea pigs were selected and divided into 3 groups randomly: 5 guniea pigs of the blank control group were not given either GPCMV or JYBD. 31 guniea pigs of the positive control group were inoculated 1 mL (10(7) TCID50) suspension of GPCMV intraperitoneal. 10 guniea pigs of the experimental group were inoculated GPCMV firstly and then perfused stomach with JYBD for 14 days (Dosage in accordance with the modulus of the weight ratio of human to guniea pig). The effects of JYBD on the intrauterine infection of GPCMV were observed. The results showed that JYBD could decrease the maternal infection rate from 100% (31/31) to 50% (5/10) (P < 0.001), the intrauterine infection rate from 100% (72/72) to 75% (21/28) (P < 0.001), and the rate of abnormal outcome of pregnancy from 64.4% (29/45) to 25.0% (7/28) (P < 0.001), the infective symptoms being relieved. It can be concluded that traditional Chinese medicine- JYBD can prevent and treat (GPCMV intrauterine infection, and can be expected a prophylactic drug for HCMV intrauterine infection.</abstract><cop>China</cop><pub>Department of obstetrics & gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China</pub><pmid>16696337</pmid><doi>10.1007/bf02896182</doi><tpages>3</tpages></addata></record> |
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| issn | 1672-0733 1993-1352 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cytomegalovirus Cytomegalovirus Infections - drug therapy Drugs, Chinese Herbal - therapeutic use Female Fetal Diseases - drug therapy Fetal Diseases - prevention & control Fetal Diseases - virology Guinea pig cytomegalovirus Guinea Pigs Human cytomegalovirus Male Phytotherapy Pregnancy Pregnancy Complications, Infectious - drug therapy Random Allocation |
| title | A study on the traditional Chinese medicine Jinyebaidu for prevention and treatment of intrauterine infection with guinea pigs cytomegalovirus |
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