Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits
This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) wer...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2005, Vol.25 (3), p.263-264 |
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| container_title | Journal of Huazhong University of Science and Technology. Medical sciences |
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| creator | 张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳 |
| description | This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system. |
| doi_str_mv | 10.1007/bf02828137 |
| format | Article |
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Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system.</description><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 1993-1352</identifier><identifier>DOI: 10.1007/bf02828137</identifier><identifier>PMID: 16201266</identifier><language>eng</language><publisher>China: Department of Physiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Internal Medicine, and Clinic, Wuhan Traditional Chinese Medical Hospital, Wuhan 430005, China</publisher><subject>Animals ; Blood Pressure - drug effects ; Depression, Chemical ; Female ; Kidney - innervation ; Male ; Microinjections ; Norepinephrine - pharmacology ; Rabbits ; Solitary Nucleus - physiology ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiopathology ; Vasomotor System - physiopathology ; 交感神经 ; 去甲肾上腺素 ; 外周血 ; 抑制作用 ; 病理机制</subject><ispartof>Journal of Huazhong University of Science and Technology. Medical sciences, 2005, Vol.25 (3), p.263-264</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2221-9370cd60ce6751e5a9c68a6fdfdcf944a577d7eba873a18efee673a955c6d48c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16201266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳</creatorcontrib><title>Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description>This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that microinjection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Depression, Chemical</subject><subject>Female</subject><subject>Kidney - innervation</subject><subject>Male</subject><subject>Microinjections</subject><subject>Norepinephrine - pharmacology</subject><subject>Rabbits</subject><subject>Solitary Nucleus - physiology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vasomotor System - physiopathology</subject><subject>交感神经</subject><subject>去甲肾上腺素</subject><subject>外周血</subject><subject>抑制作用</subject><subject>病理机制</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9vFSEUxYnR2Frd-AEMceFCM8qfAWaW9dlqk6qJresJw1z6eJ2BKQyx3fjZ5fnGuOGSc38cuByEXlLynhKiPvSWsIY1lKtH6Ji2La8oF-xx2UvFKqI4P0LPUtoRIpRk9VN0RCUjlEl5jH5_BbPV3qUp4WDxJ5gjpBQiPrMWzLLXvoUIs_Mwb2NZ8YXflQYM2Pkl4Kvc-2xGyAlvwjS5lHJ0-e-xVb4Ko1t0ERO-jtospTqPf-i-d0t6jp5YPSZ4sdYT9PP87Hrzpbr8_vlic3pZGcYYrVquiBkkMSCVoCB0a2SjpR3sYGxb11ooNSjodaO4pg1YKCDXrRBGDnVj-Al6d_D9pb3V_qbbhRx9ubFbdg-3w_193wEr_0M4obTQbw70HMNdhrR0ZTAD46g9hJw62UgheFMX8O0BNDGkFMF2c3STjg8dJd0-m-7j-b9sCvxqdc39BMN_dA2jAK9Xt23wN3euPLPX5ta6EfYQZXVN-B_d2Zb-</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳</creator><general>Department of Physiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Internal Medicine, and Clinic, Wuhan Traditional Chinese Medical Hospital, Wuhan 430005, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits</title><author>张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2221-9370cd60ce6751e5a9c68a6fdfdcf944a577d7eba873a18efee673a955c6d48c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Depression, Chemical</topic><topic>Female</topic><topic>Kidney - innervation</topic><topic>Male</topic><topic>Microinjections</topic><topic>Norepinephrine - pharmacology</topic><topic>Rabbits</topic><topic>Solitary Nucleus - physiology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Vasomotor System - physiopathology</topic><topic>交感神经</topic><topic>去甲肾上腺素</topic><topic>外周血</topic><topic>抑制作用</topic><topic>病理机制</topic><toplevel>online_resources</toplevel><creatorcontrib>张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>张毅 骆红艳 刘胜红 易正荣 李爱 胡新武 刘长金 唐明 刘烈炬 宋元龙 高琳琳</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2005</date><risdate>2005</risdate><volume>25</volume><issue>3</issue><spage>263</spage><epage>264</epage><pages>263-264</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE)was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. 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| identifier | ISSN: 1672-0733 |
| ispartof | Journal of Huazhong University of Science and Technology. Medical sciences, 2005, Vol.25 (3), p.263-264 |
| issn | 1672-0733 1993-1352 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood Pressure - drug effects Depression, Chemical Female Kidney - innervation Male Microinjections Norepinephrine - pharmacology Rabbits Solitary Nucleus - physiology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Vasomotor System - physiopathology 交感神经 去甲肾上腺素 外周血 抑制作用 病理机制 |
| title | Mechanisms of Depressor Effect of Norepinephrine Injected into Subnucleus Commissuriu of Nucleus Solitarius Tractus in Rabbits |
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