Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats
To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles...
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Veröffentlicht in: | Current medical science 2005, Vol.25 (2), p.191-193 |
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description | To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P |
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The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. It is concluded that exercise can promote the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats, which may be one of the mechanisms responsible for the amelioration of insulin resistance in the rats.]]></description><identifier>ISSN: 1672-0733</identifier><identifier>ISSN: 2096-5230</identifier><identifier>EISSN: 1993-1352</identifier><identifier>EISSN: 2523-899X</identifier><identifier>DOI: 10.1007/bf02873574</identifier><identifier>PMID: 16116970</identifier><language>eng</language><publisher>China: Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</publisher><subject>2型糖尿病 ; Adiponectin - biosynthesis ; Adiponectin - genetics ; Animals ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Type 2 - metabolism ; Glucose Transporter Type 4 - biosynthesis ; Glucose Transporter Type 4 - genetics ; GLUT4 ; Male ; mRNA ; Physical Exertion ; Rats ; Rats, Wistar ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; 功能锻炼 ; 动物实验 ; 脂肪细胞</subject><ispartof>Current medical science, 2005, Vol.25 (2), p.191-193</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2943-ebfa7f092c28b0eaeb9edbabe04588dcf65fbbad11177d94928597572c350ef43</citedby><cites>FETCH-LOGICAL-c2943-ebfa7f092c28b0eaeb9edbabe04588dcf65fbbad11177d94928597572c350ef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16116970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>唐兆生 袁莉 谷成英 刘贇 祝炼</creatorcontrib><title>Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats</title><title>Current medical science</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description><![CDATA[To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. It is concluded that exercise can promote the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats, which may be one of the mechanisms responsible for the amelioration of insulin resistance in the rats.]]></description><subject>2型糖尿病</subject><subject>Adiponectin - biosynthesis</subject><subject>Adiponectin - genetics</subject><subject>Animals</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Glucose Transporter Type 4 - biosynthesis</subject><subject>Glucose Transporter Type 4 - genetics</subject><subject>GLUT4</subject><subject>Male</subject><subject>mRNA</subject><subject>Physical Exertion</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>功能锻炼</subject><subject>动物实验</subject><subject>脂肪细胞</subject><issn>1672-0733</issn><issn>2096-5230</issn><issn>1993-1352</issn><issn>2523-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9PHCEYh4nRqLW9-AEM8dBDm1H-DDAct3a1JhtNzHomwLwo6y4zDrPp7rcvZrfpsSf4wZPnDfwQOqfkihKirl0grFFcqPoAnVKteUW5YIdlLxWriOL8BH3KeUGIUJLVx-iESkqlVuQUmWkI4EfcBTzdwOBjBtwlPL5Cyf0AOccSy-2kjX2XChoTXj09TLBNLb6bPc_rXSzH820PmOGf0ToYo8dPdsyf0VGwywxf9usZer6dzm9-VbPHu_ubyazyTNe8AhesCkQzzxpHwILT0LriIbVomtYHKYJztqWUKtXqWrNGaCUU81wQCDU_Q9933t82BZtezKJbD6lMNONi-9ZuNs4AKx9AGGG80F93dD9072vIo1nF7GG5tAm6dTayEUTyRv4XpKouUv4x_9sO9EOX8wDB9ENc2WFrKDEfLZkft39bKvDF3rp2K2j_oftaCnC5t7126eU9lvc4699CXIKhQkpNqOZ_AJNElYU</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>唐兆生 袁莉 谷成英 刘贇 祝炼</creator><general>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TS</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats</title><author>唐兆生 袁莉 谷成英 刘贇 祝炼</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2943-ebfa7f092c28b0eaeb9edbabe04588dcf65fbbad11177d94928597572c350ef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2型糖尿病</topic><topic>Adiponectin - biosynthesis</topic><topic>Adiponectin - genetics</topic><topic>Animals</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Glucose Transporter Type 4 - biosynthesis</topic><topic>Glucose Transporter Type 4 - genetics</topic><topic>GLUT4</topic><topic>Male</topic><topic>mRNA</topic><topic>Physical Exertion</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>功能锻炼</topic><topic>动物实验</topic><topic>脂肪细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>唐兆生 袁莉 谷成英 刘贇 祝炼</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>唐兆生 袁莉 谷成英 刘贇 祝炼</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats</atitle><jtitle>Current medical science</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2005</date><risdate>2005</risdate><volume>25</volume><issue>2</issue><spage>191</spage><epage>193</epage><pages>191-193</pages><issn>1672-0733</issn><issn>2096-5230</issn><eissn>1993-1352</eissn><eissn>2523-899X</eissn><abstract><![CDATA[To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. It is concluded that exercise can promote the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats, which may be one of the mechanisms responsible for the amelioration of insulin resistance in the rats.]]></abstract><cop>China</cop><pub>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</pub><pmid>16116970</pmid><doi>10.1007/bf02873574</doi><tpages>3</tpages></addata></record> |
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subjects | 2型糖尿病 Adiponectin - biosynthesis Adiponectin - genetics Animals Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - metabolism Glucose Transporter Type 4 - biosynthesis Glucose Transporter Type 4 - genetics GLUT4 Male mRNA Physical Exertion Rats Rats, Wistar RNA, Messenger - biosynthesis RNA, Messenger - genetics 功能锻炼 动物实验 脂肪细胞 |
title | Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats |
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