Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats

To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles...

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Veröffentlicht in:Current medical science 2005, Vol.25 (2), p.191-193
1. Verfasser: 唐兆生 袁莉 谷成英 刘贇 祝炼
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description To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P
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The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. It is concluded that exercise can promote the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats, which may be one of the mechanisms responsible for the amelioration of insulin resistance in the rats.]]></description><identifier>ISSN: 1672-0733</identifier><identifier>ISSN: 2096-5230</identifier><identifier>EISSN: 1993-1352</identifier><identifier>EISSN: 2523-899X</identifier><identifier>DOI: 10.1007/bf02873574</identifier><identifier>PMID: 16116970</identifier><language>eng</language><publisher>China: Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</publisher><subject>2型糖尿病 ; Adiponectin - biosynthesis ; Adiponectin - genetics ; Animals ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Type 2 - metabolism ; Glucose Transporter Type 4 - biosynthesis ; Glucose Transporter Type 4 - genetics ; GLUT4 ; Male ; mRNA ; Physical Exertion ; Rats ; Rats, Wistar ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; 功能锻炼 ; 动物实验 ; 脂肪细胞</subject><ispartof>Current medical science, 2005, Vol.25 (2), p.191-193</ispartof><rights>Copyright © Wanfang Data Co. 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All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2943-ebfa7f092c28b0eaeb9edbabe04588dcf65fbbad11177d94928597572c350ef43</citedby><cites>FETCH-LOGICAL-c2943-ebfa7f092c28b0eaeb9edbabe04588dcf65fbbad11177d94928597572c350ef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16116970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>唐兆生 袁莉 谷成英 刘贇 祝炼</creatorcontrib><title>Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats</title><title>Current medical science</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description><![CDATA[To investigate the impact of exercise on the expression of adiponectin and GLUT4 mRNA in type 2 diabetic rats, type 2 diabetic rat model was made. The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. 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biosynthesis</topic><topic>Adiponectin - genetics</topic><topic>Animals</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Glucose Transporter Type 4 - biosynthesis</topic><topic>Glucose Transporter Type 4 - genetics</topic><topic>GLUT4</topic><topic>Male</topic><topic>mRNA</topic><topic>Physical Exertion</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>功能锻炼</topic><topic>动物实验</topic><topic>脂肪细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>唐兆生 袁莉 谷成英 刘贇 祝炼</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - 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The diabetic rats were treated with swimming training for 8 weeks. The expression of adiponectin mRNA in perirenal fat and GLUT4 mRNA in skeletal muscles were assessed by reverse transcription polymerase chain reaction (RTPCR) and the levels of blood glucose, serum insulin, and blood lipid were measured. Our results showed that the expression of adiponectin mRNA and GLUT4 mRNA in diabetic model group was decreased by 45 % (P<0.01), 43 % (P<0.01) respectively. The gene expression of adiponectin and GI.UT4 was increased significantly in swimming group (P<0.05 and P<0.01, respectively). Compared with the model group, fasting insulin, TG, TC and FFA were decreased significantly in the training group (P<0.05 or P<0.01) as compared with model group. 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subjects 2型糖尿病
Adiponectin - biosynthesis
Adiponectin - genetics
Animals
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Type 2 - metabolism
Glucose Transporter Type 4 - biosynthesis
Glucose Transporter Type 4 - genetics
GLUT4
Male
mRNA
Physical Exertion
Rats
Rats, Wistar
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
功能锻炼
动物实验
脂肪细胞
title Effect of Exercise on the Expression of Adiponectin mRNA and GLUT4 mRNA in Type 2 Diabetic Rats
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