Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia
In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene prote...
Gespeichert in:
| Veröffentlicht in: | Current medical science 2005, Vol.25 (1), p.29-31 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 31 |
|---|---|
| container_issue | 1 |
| container_start_page | 29 |
| container_title | Current medical science |
| container_volume | 25 |
| creator | 王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先 |
| description | In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene protein and mRNA, respectively in 59 children with AA and 51 normal controls. The relationship between SCF and c-kit and the pathogenesis of AA was analyzed subsequently. The results showed that the positive rate of SCF protein and mRNA expression in children with AA was significantly lower than that in healthy controls (P0.05). It was concluded that the expression of SCF is significantly decreased in children with AA, which may be closely associated with the pathogenesis of the AA. c-kit may be unrelated to the development of pediatric AA. Therefore, AA in children may have abnormalities at SCF/c-kit signal transduction levels. |
| doi_str_mv | 10.1007/bf02831379 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_tjykdxxb_e200501009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>15163762</cqvip_id><wanfj_id>tjykdxxb_e200501009</wanfj_id><sourcerecordid>tjykdxxb_e200501009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2539-f8f8fbabf5a5bdc7afa1ebb2e2bab282fad88daf192d33bd2ffb2f31286470123</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0Eoh9w4QcgiwOHooA_NnFybFcsVKpEVeDCxRrH411vE3sbe0X773G0iziiOXg0euYdvX4JecPZR86Y-mQcE63kUnXPyCnvOllxWYvnpW-UqJiS8oScpbRlrFaNWLwkJ7zu5EIyfkp-3cUBaXT0e8aRLnEY6Ar6HCcKwdLrnOgd9ribBz7QvEF6C3kT1xgw-TQv3qL1kCff08vdACnPTcDRwyvywsGQ8PXxPSc_V59_LL9WN9--XC8vb6pe1LKrXFvKgHE11Mb2ChxwNEagKEPRCge2bS043gkrpbHCOSOc5KJtFopxIc_Jh4PubwgOwlpv434K5aLO26d7-_hoNIrinZXP6gr9_kDvpviwx5T16FNffEPAuE-6UW2nRMf-C3IlF0LI-f7FAeynmNKETu8mP8L0pDnTc0D6avU3oAK_ParuzYj2H3pMpADvjmqbGNYPvvgx0N87P2CBeCNLhPIPF-eV7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17342232</pqid></control><display><type>article</type><title>Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Alma/SFX Local Collection</source><creator>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</creator><creatorcontrib>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</creatorcontrib><description>In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene protein and mRNA, respectively in 59 children with AA and 51 normal controls. The relationship between SCF and c-kit and the pathogenesis of AA was analyzed subsequently. The results showed that the positive rate of SCF protein and mRNA expression in children with AA was significantly lower than that in healthy controls (P<0.05). However, there was no significant difference in the positive rate of c-kit protein and mRNA expression between children with AA and control group (P>0.05). It was concluded that the expression of SCF is significantly decreased in children with AA, which may be closely associated with the pathogenesis of the AA. c-kit may be unrelated to the development of pediatric AA. Therefore, AA in children may have abnormalities at SCF/c-kit signal transduction levels.</description><identifier>ISSN: 1672-0733</identifier><identifier>ISSN: 2096-5230</identifier><identifier>EISSN: 1993-1352</identifier><identifier>EISSN: 2523-899X</identifier><identifier>DOI: 10.1007/bf02831379</identifier><identifier>PMID: 15934301</identifier><language>eng</language><publisher>China: Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</publisher><subject>Adolescent ; Anemia, Aplastic - etiology ; Anemia, Aplastic - metabolism ; Child ; Child, Preschool ; Female ; Humans ; Male ; Receptors, Colony-Stimulating Factor - biosynthesis ; Receptors, Colony-Stimulating Factor - genetics ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Stem Cell Factor - biosynthesis ; Stem Cell Factor - genetics ; 再生障碍性贫血 ; 发病机制 ; 干细胞</subject><ispartof>Current medical science, 2005, Vol.25 (1), p.29-31</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2539-f8f8fbabf5a5bdc7afa1ebb2e2bab282fad88daf192d33bd2ffb2f31286470123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15934301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</creatorcontrib><title>Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia</title><title>Current medical science</title><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><description>In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene protein and mRNA, respectively in 59 children with AA and 51 normal controls. The relationship between SCF and c-kit and the pathogenesis of AA was analyzed subsequently. The results showed that the positive rate of SCF protein and mRNA expression in children with AA was significantly lower than that in healthy controls (P<0.05). However, there was no significant difference in the positive rate of c-kit protein and mRNA expression between children with AA and control group (P>0.05). It was concluded that the expression of SCF is significantly decreased in children with AA, which may be closely associated with the pathogenesis of the AA. c-kit may be unrelated to the development of pediatric AA. Therefore, AA in children may have abnormalities at SCF/c-kit signal transduction levels.</description><subject>Adolescent</subject><subject>Anemia, Aplastic - etiology</subject><subject>Anemia, Aplastic - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Receptors, Colony-Stimulating Factor - biosynthesis</subject><subject>Receptors, Colony-Stimulating Factor - genetics</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Stem Cell Factor - biosynthesis</subject><subject>Stem Cell Factor - genetics</subject><subject>再生障碍性贫血</subject><subject>发病机制</subject><subject>干细胞</subject><issn>1672-0733</issn><issn>2096-5230</issn><issn>1993-1352</issn><issn>2523-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0Eoh9w4QcgiwOHooA_NnFybFcsVKpEVeDCxRrH411vE3sbe0X773G0iziiOXg0euYdvX4JecPZR86Y-mQcE63kUnXPyCnvOllxWYvnpW-UqJiS8oScpbRlrFaNWLwkJ7zu5EIyfkp-3cUBaXT0e8aRLnEY6Ar6HCcKwdLrnOgd9ribBz7QvEF6C3kT1xgw-TQv3qL1kCff08vdACnPTcDRwyvywsGQ8PXxPSc_V59_LL9WN9--XC8vb6pe1LKrXFvKgHE11Mb2ChxwNEagKEPRCge2bS043gkrpbHCOSOc5KJtFopxIc_Jh4PubwgOwlpv434K5aLO26d7-_hoNIrinZXP6gr9_kDvpviwx5T16FNffEPAuE-6UW2nRMf-C3IlF0LI-f7FAeynmNKETu8mP8L0pDnTc0D6avU3oAK_ParuzYj2H3pMpADvjmqbGNYPvvgx0N87P2CBeCNLhPIPF-eV7g</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</creator><general>Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</general><general>Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China%Department of Pediatrics, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China%Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia</title><author>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2539-f8f8fbabf5a5bdc7afa1ebb2e2bab282fad88daf192d33bd2ffb2f31286470123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Anemia, Aplastic - etiology</topic><topic>Anemia, Aplastic - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Receptors, Colony-Stimulating Factor - biosynthesis</topic><topic>Receptors, Colony-Stimulating Factor - genetics</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Stem Cell Factor - biosynthesis</topic><topic>Stem Cell Factor - genetics</topic><topic>再生障碍性贫血</topic><topic>发病机制</topic><topic>干细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>王军 冯建飞 王伟 胡豫 赵雪莲 王宏 朱绍先</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia</atitle><jtitle>Current medical science</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2005</date><risdate>2005</risdate><volume>25</volume><issue>1</issue><spage>29</spage><epage>31</epage><pages>29-31</pages><issn>1672-0733</issn><issn>2096-5230</issn><eissn>1993-1352</eissn><eissn>2523-899X</eissn><abstract>In order to investigate the levels of stem cell factor (SCF) and its receptor c-kit protein and mRNA in pediatric aplastic anemia (AA) and their relevance to the pathogenesis, immunocytochemical and in situ hybridization were utilized to detect the expression of SCF and its receptor c-kit gene protein and mRNA, respectively in 59 children with AA and 51 normal controls. The relationship between SCF and c-kit and the pathogenesis of AA was analyzed subsequently. The results showed that the positive rate of SCF protein and mRNA expression in children with AA was significantly lower than that in healthy controls (P<0.05). However, there was no significant difference in the positive rate of c-kit protein and mRNA expression between children with AA and control group (P>0.05). It was concluded that the expression of SCF is significantly decreased in children with AA, which may be closely associated with the pathogenesis of the AA. c-kit may be unrelated to the development of pediatric AA. Therefore, AA in children may have abnormalities at SCF/c-kit signal transduction levels.</abstract><cop>China</cop><pub>Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China</pub><pmid>15934301</pmid><doi>10.1007/bf02831379</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-0733 |
| ispartof | Current medical science, 2005, Vol.25 (1), p.29-31 |
| issn | 1672-0733 2096-5230 1993-1352 2523-899X |
| language | eng |
| recordid | cdi_wanfang_journals_tjykdxxb_e200501009 |
| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | Adolescent Anemia, Aplastic - etiology Anemia, Aplastic - metabolism Child Child, Preschool Female Humans Male Receptors, Colony-Stimulating Factor - biosynthesis Receptors, Colony-Stimulating Factor - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Stem Cell Factor - biosynthesis Stem Cell Factor - genetics 再生障碍性贫血 发病机制 干细胞 |
| title | Role of Stem Cell Factor and Its Receptor in the Pathogenesis of Pediatric Aplastic Anemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T06%3A13%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Stem%20Cell%20Factor%20and%20Its%20Receptor%20in%20the%20Pathogenesis%20of%20Pediatric%20Aplastic%20Anemia&rft.jtitle=Current%20medical%20science&rft.au=%E7%8E%8B%E5%86%9B%20%E5%86%AF%E5%BB%BA%E9%A3%9E%20%E7%8E%8B%E4%BC%9F%20%E8%83%A1%E8%B1%AB%20%E8%B5%B5%E9%9B%AA%E8%8E%B2%20%E7%8E%8B%E5%AE%8F%20%E6%9C%B1%E7%BB%8D%E5%85%88&rft.date=2005&rft.volume=25&rft.issue=1&rft.spage=29&rft.epage=31&rft.pages=29-31&rft.issn=1672-0733&rft.eissn=1993-1352&rft_id=info:doi/10.1007/bf02831379&rft_dat=%3Cwanfang_jour_proqu%3Etjykdxxb_e200501009%3C/wanfang_jour_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17342232&rft_id=info:pmid/15934301&rft_cqvip_id=15163762&rft_wanfj_id=tjykdxxb_e200501009&rfr_iscdi=true |