Effects of Cadmium on BMP Induced Bone Formation
To demonstrate the direct effects of cadmium on activities of bone morphogenetic protein (BMP).a complex containing BMP and cadmium chloride(CdCl2)was implanted beneath the abdominal skin of young male Wistar rats.The activity of BMP was wtudied by observing the histological changes,and measuring th...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2003, Vol.23 (1), p.91-93 |
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| container_title | Journal of Huazhong University of Science and Technology. Medical sciences |
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| creator | 陈秋生 徐顺清 |
| description | To demonstrate the direct effects of cadmium on activities of bone morphogenetic protein (BMP).a complex containing BMP and cadmium chloride(CdCl2)was implanted beneath the abdominal skin of young male Wistar rats.The activity of BMP was wtudied by observing the histological changes,and measuring the activity of alkaline phosphatase(ALP) and acid posphatase(ACP) and calcium content of the implants at different time points.Our results showed that during bone formation induced by BMP.cadmium inhibited the activities of osteoblasts and osteoclasts,and slowed the deposition of calcium.It is concluded that cadmium can directly affect biological activities of BMP directly. |
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Medical sciences</jtitle><addtitle>Journal of Zuazhong University of Science and Technology: Medical Edition</addtitle><date>2003</date><risdate>2003</risdate><volume>23</volume><issue>1</issue><spage>91</spage><epage>93</epage><pages>91-93</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>To demonstrate the direct effects of cadmium on activities of bone morphogenetic protein (BMP).a complex containing BMP and cadmium chloride(CdCl2)was implanted beneath the abdominal skin of young male Wistar rats.The activity of BMP was wtudied by observing the histological changes,and measuring the activity of alkaline phosphatase(ALP) and acid posphatase(ACP) and calcium content of the implants at different time points.Our results showed that during bone formation induced by BMP.cadmium inhibited the activities of osteoblasts and osteoclasts,and slowed the deposition of calcium.It is concluded that cadmium can directly affect biological activities of BMP directly.</abstract><pub>Department of Environmental Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</pub><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-0733 |
| ispartof | Journal of Huazhong University of Science and Technology. Medical sciences, 2003, Vol.23 (1), p.91-93 |
| issn | 1672-0733 1993-1352 |
| language | eng |
| recordid | cdi_wanfang_journals_tjykdxxb_e200301030 |
| source | Alma/SFX Local Collection |
| subjects | BMD 成骨作用 骨形态发生蛋白 |
| title | Effects of Cadmium on BMP Induced Bone Formation |
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