Facile Synthesis of [1,2,4]Triazolo[4,3-a]pyrazin-3-amines via Oxidative Cyclization of 1-(Pyrazin-2-yl)guanidine Derivatives

In this study, we applied a novel, mild, and convenient synthetic method involving the oxidative cyclization of 1-(pyrazin-2-yl)guanidine derivatives to produce [1,2,4]triazolo[4,3- a ]pyrazin-3-amines. We optimized the reaction procedure to easily obtain 5-chloro-[1,2,4]triazolo[4,3- a ]pyrazin-3-a...

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Veröffentlicht in:	Transactions of Tianjin University 2019-04, Vol.25 (2), p.185-194
Hauptverfasser:	Li, Wei, Kang, Jieqiong, Zhou, Xueqin, Liu, Dongzhi, Sun, Haiya, Xu, Fang, Wang, Tianyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Derivatives Engineering Guanidines Humanities and Social Sciences Mechanical Engineering multidisciplinary NMR Nuclear magnetic resonance Overhauser effect Pyrazines Research Article Science
Online-Zugang:	Volltext
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