猪丹毒丝菌spaA基因的敲除及其致病作用的初步研究
S852.6; 为阐明SpaA在猪丹毒丝菌致病中的作用,以临床分离的猪丹毒丝菌野生强毒株为材料采用DNA重组技术构建spaA基因敲除载体,并利用该敲除载体通过同源重组敲除强毒株的spaA基因,比较强毒株和敲除株对小鼠毒力的差异.结果表明敲除株相比野生株对小鼠的毒力降低102倍,这说明SpaA与猪丹毒丝菌的致病性有关....
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| Veröffentlicht in: | 韶关学院学报 2020, Vol.41 (3), p.46-51 |
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| container_title | 韶关学院学报 |
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| creator | 陈富海 林晓君 凃彦芳 刘博婷 余璐 蔡巩林 林锦铨 彭凌 |
| description | S852.6; 为阐明SpaA在猪丹毒丝菌致病中的作用,以临床分离的猪丹毒丝菌野生强毒株为材料采用DNA重组技术构建spaA基因敲除载体,并利用该敲除载体通过同源重组敲除强毒株的spaA基因,比较强毒株和敲除株对小鼠毒力的差异.结果表明敲除株相比野生株对小鼠的毒力降低102倍,这说明SpaA与猪丹毒丝菌的致病性有关. |
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| source | 国家哲学社会科学学术期刊数据库 (National Social Sciences Database) |
| title | 猪丹毒丝菌spaA基因的敲除及其致病作用的初步研究 |
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