N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion
The effect of TACO 1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-in...
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| Veröffentlicht in: | Tsinghua science and technology 2005, Vol.10 (4), p.489-495 |
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| creator | Liu, Changzhen Sui, Senfang |
| description | The effect of TACO
1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-induced differentiation were observed by fluorescence microscopy. The results show that the overexpression of TACO
1-299 inhibits cell adhesion while overexpressions of the other proteins do not have this effect. The actin-binding capability of TACO
1-299 was investigated and the results show that TACO
1-299 lacks the ability of TACO to bind F-actin. The inhibitive effect of TACO
1-299, the functional domain of TACO, suggests that TACO may play a role in cell differentiation mediating adhesion of monoblastic leukemia cells. |
| doi_str_mv | 10.1016/S1007-0214(05)70105-X |
| format | Article |
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1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-induced differentiation were observed by fluorescence microscopy. The results show that the overexpression of TACO
1-299 inhibits cell adhesion while overexpressions of the other proteins do not have this effect. The actin-binding capability of TACO
1-299 was investigated and the results show that TACO
1-299 lacks the ability of TACO to bind F-actin. The inhibitive effect of TACO
1-299, the functional domain of TACO, suggests that TACO may play a role in cell differentiation mediating adhesion of monoblastic leukemia cells.</description><identifier>ISSN: 1007-0214</identifier><identifier>EISSN: 1878-7606</identifier><identifier>EISSN: 1007-0214</identifier><identifier>DOI: 10.1016/S1007-0214(05)70105-X</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>cell adhesion ; differentiation ; TACO ; U937 cell</subject><ispartof>Tsinghua science and technology, 2005, Vol.10 (4), p.489-495</ispartof><rights>2005 Tsinghua University Press</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/qhdxxb-e/qhdxxb-e.jpg</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids></links><search><creatorcontrib>Liu, Changzhen</creatorcontrib><creatorcontrib>Sui, Senfang</creatorcontrib><title>N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion</title><title>Tsinghua science and technology</title><description>The effect of TACO
1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-induced differentiation were observed by fluorescence microscopy. The results show that the overexpression of TACO
1-299 inhibits cell adhesion while overexpressions of the other proteins do not have this effect. The actin-binding capability of TACO
1-299 was investigated and the results show that TACO
1-299 lacks the ability of TACO to bind F-actin. The inhibitive effect of TACO
1-299, the functional domain of TACO, suggests that TACO may play a role in cell differentiation mediating adhesion of monoblastic leukemia cells.</description><subject>cell adhesion</subject><subject>differentiation</subject><subject>TACO</subject><subject>U937 cell</subject><issn>1007-0214</issn><issn>1878-7606</issn><issn>1007-0214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkF9LwzAUxYMoOKcfQeije4jetEnTPkkp_hlMJ9jB3kKapi6jSzXZdH57s02fhQv3Ppxz7z0_hC4JXBMg6c0rAeAYYkKvgI04EGB4foQGJOMZ5imkx2H-k5yiM--XAEnKeDJAd8-40m5lrOyiym2skmvT26hvo6oop9HYLkxt1j56eSrw2DYbpZtolic8KnXXRUWz0D7oz9FJKzuvL377EM3u76ryEU-mD-OymGAVQ8owD_cpxDXJ0rxtNWQ6zqkiudKU5zFVGUtlI1XdZhnJY5JQKXOuk1CMMyqTZIhGh71f0rbSvollv3HhdS8-Fs12WwsdAzCgQFjQsoNWud57p1vx7sxKum9BQOy4iT03sYMigIk9NzEPvtuDT4cgn0Y74ZXRNgQ3Tqu1aHrzz4YfL1xxXg</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Liu, Changzhen</creator><creator>Sui, Senfang</creator><general>Elsevier Ltd</general><general>Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion</title><author>Liu, Changzhen ; Sui, Senfang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2065-7214402b1869ffe08e294c19ce47924c856adacbf88192134aa97e37e35754a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>cell adhesion</topic><topic>differentiation</topic><topic>TACO</topic><topic>U937 cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Changzhen</creatorcontrib><creatorcontrib>Sui, Senfang</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Tsinghua science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Changzhen</au><au>Sui, Senfang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion</atitle><jtitle>Tsinghua science and technology</jtitle><date>2005</date><risdate>2005</risdate><volume>10</volume><issue>4</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>1007-0214</issn><eissn>1878-7606</eissn><eissn>1007-0214</eissn><abstract>The effect of TACO
1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-induced differentiation were observed by fluorescence microscopy. The results show that the overexpression of TACO
1-299 inhibits cell adhesion while overexpressions of the other proteins do not have this effect. The actin-binding capability of TACO
1-299 was investigated and the results show that TACO
1-299 lacks the ability of TACO to bind F-actin. The inhibitive effect of TACO
1-299, the functional domain of TACO, suggests that TACO may play a role in cell differentiation mediating adhesion of monoblastic leukemia cells.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/S1007-0214(05)70105-X</doi><tpages>7</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | cell adhesion differentiation TACO U937 cell |
| title | N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion |
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