Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression
Majority of cancer patients die from cancer metastases. The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells. Blood vessel is one of the “pathways” for cancer to metastasize, in which tumor cells need to cross the endothelial barrier for intravasation and...
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| Veröffentlicht in: | Acta mechanica Sinica 2021-02, Vol.37 (2), p.218-228 |
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| container_title | Acta mechanica Sinica |
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| creator | Wei, Changling Tang, Mei Xu, Zhiling Yang, Li Lv, Yonggang |
| description | Majority of cancer patients die from cancer metastases. The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells. Blood vessel is one of the “pathways” for cancer to metastasize, in which tumor cells need to cross the endothelial barrier for intravasation and extravasation. Tumor vessels are arranged in untraditional hierarchies and characterized with rupture, bend, swell and high permeability that are beneficial to intravasation of cancer cell. Abnormal vessels are accompanied with uneven blood flow, increased compression and interstitial fluid pressure. Meanwhile, excessive proliferation of tumor leads to low oxygen pressure in solid tumor. The aberrant tumor mechanical microenvironment changes the biochemical and mechanical signal transduction of endothelial cells and participates in tumor progression. Many current researches focus on how chemical signals regulate endothelial cell function while the role of physical cues is unclear. In this review, the role of endothelial cells in the regulation of shear stress, intercellular force, extracellular matrix and pressure on tumor progression is summarized.
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| doi_str_mv | 10.1007/s10409-021-01056-4 |
| format | Article |
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Graphic Abstract</description><subject>Blood flow</subject><subject>Blood vessels</subject><subject>Cancer</subject><subject>Classical and Continuum Physics</subject><subject>Computational Intelligence</subject><subject>Endothelial cells</subject><subject>Engineering</subject><subject>Engineering Fluid Dynamics</subject><subject>Fluid pressure</subject><subject>Hierarchies</subject><subject>Review</subject><subject>Shear stress</subject><subject>Signal transduction</subject><subject>Theoretical and Applied Mechanics</subject><subject>Tumors</subject><issn>0567-7718</issn><issn>1614-3116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-AU8FD56qM0nadI-y-AULgug5pHXa7dIma9Lq-u-NVtibp8DwvO9kHsbOEa4QQF0HBAmLFDimgJDlqTxgM8xRpgIxP2SzOFOpUlgcs5MQNgAiR4Uzpp9dR4mrE7JvblhT15ouqajrQtLaJA4ST83YmaF19gfrqVob21aR6tvKO7IfrXe2JzskkRjG3vlk613jKYSYOWVHtekCnf29c_Z6d_uyfEhXT_ePy5tVWokMh5RLqCpJUomyMLKADEpVEAERyVKRAmEUV3WNRomskBnmGRdQG6nqEgUUYs4up95PY2tjG71xo7dxo-52u1ITj2qAR1WRvJjI-Mv3kcKwR3mGXCxgkeeR4hMVbwzBU623vu2N_9II-ke5npTr2Kt_lWsZQ2IKhQjbhvy--p_UN35Dg9Q</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Wei, Changling</creator><creator>Tang, Mei</creator><creator>Xu, Zhiling</creator><creator>Yang, Li</creator><creator>Lv, Yonggang</creator><general>The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences</general><general>Springer Nature B.V</general><general>Mechanobiology and Regenerative Medicine Laboratory,Bioengineering College,Chongqing University,Chongqing 400044,China</general><general>Key Laboratory of Biorheological Science and Technology(Chongqing University),Ministry of Education,Bioengineering College,Chongqing University,Chongqing 400044,China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20210201</creationdate><title>Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression</title><author>Wei, Changling ; Tang, Mei ; Xu, Zhiling ; Yang, Li ; Lv, Yonggang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-240cc4e473b8a48050b78ee0eee4b7e703a727ff1a735845165230fa47fb13083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood flow</topic><topic>Blood vessels</topic><topic>Cancer</topic><topic>Classical and Continuum Physics</topic><topic>Computational Intelligence</topic><topic>Endothelial cells</topic><topic>Engineering</topic><topic>Engineering Fluid Dynamics</topic><topic>Fluid pressure</topic><topic>Hierarchies</topic><topic>Review</topic><topic>Shear stress</topic><topic>Signal transduction</topic><topic>Theoretical and Applied Mechanics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Changling</creatorcontrib><creatorcontrib>Tang, Mei</creatorcontrib><creatorcontrib>Xu, Zhiling</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Lv, Yonggang</creatorcontrib><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Acta mechanica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Changling</au><au>Tang, Mei</au><au>Xu, Zhiling</au><au>Yang, Li</au><au>Lv, Yonggang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression</atitle><jtitle>Acta mechanica Sinica</jtitle><stitle>Acta Mech. Sin</stitle><date>2021-02-01</date><risdate>2021</risdate><volume>37</volume><issue>2</issue><spage>218</spage><epage>228</epage><pages>218-228</pages><issn>0567-7718</issn><eissn>1614-3116</eissn><abstract>Majority of cancer patients die from cancer metastases. The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells. Blood vessel is one of the “pathways” for cancer to metastasize, in which tumor cells need to cross the endothelial barrier for intravasation and extravasation. Tumor vessels are arranged in untraditional hierarchies and characterized with rupture, bend, swell and high permeability that are beneficial to intravasation of cancer cell. Abnormal vessels are accompanied with uneven blood flow, increased compression and interstitial fluid pressure. Meanwhile, excessive proliferation of tumor leads to low oxygen pressure in solid tumor. The aberrant tumor mechanical microenvironment changes the biochemical and mechanical signal transduction of endothelial cells and participates in tumor progression. Many current researches focus on how chemical signals regulate endothelial cell function while the role of physical cues is unclear. In this review, the role of endothelial cells in the regulation of shear stress, intercellular force, extracellular matrix and pressure on tumor progression is summarized.
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| subjects | Blood flow Blood vessels Cancer Classical and Continuum Physics Computational Intelligence Endothelial cells Engineering Engineering Fluid Dynamics Fluid pressure Hierarchies Review Shear stress Signal transduction Theoretical and Applied Mechanics Tumors |
| title | Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression |
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