线粒体障碍在非酒精性脂肪性肝炎中的作用机制
R575.5; 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病.研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用.以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗....
Gespeichert in:
| Veröffentlicht in: | 临床肝胆病杂志 2021-08, Vol.37 (8), p.1953-1956 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | chi |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1956 |
|---|---|
| container_issue | 8 |
| container_start_page | 1953 |
| container_title | 临床肝胆病杂志 |
| container_volume | 37 |
| creator | 蔡恬莹 黄美州 陈浩 钱保林 付文广 |
| description | R575.5; 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病.研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用.以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗. |
| doi_str_mv | 10.3969/j.issn.1001-5256.2021.08.045 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour</sourceid><recordid>TN_cdi_wanfang_journals_lcgdbzz202108048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>lcgdbzz202108048</wanfj_id><sourcerecordid>lcgdbzz202108048</sourcerecordid><originalsourceid>FETCH-LOGICAL-s1038-d610a12a5e2cbfc7b237aec915bde651fb6c05f4d7d1a3d3eeb29917a292f4c3</originalsourceid><addsrcrecordid>eNo9j7tKA0EARadQMMT8hYXNrvPYmd2pRIIvCNikD_MMCWEFBxFSyRLBRotoFTYWNgbBJoVIIPozm0z2LzQoVvdyinu4AOwgGBLO-F437DiXhghCFFBMWYghRiFMQhjRDVD551ug5lxHQooI4xFlFbDvZ19-OizmD-Uo9893i3xSjp_Km6Gffi6vX1aDbJW9rks29tl98fHmR4NinvvHyTKfLW7ft8GmFT1nan9ZBc2jw2b9JGicHZ_WDxqBQ5AkgWYICoQFNVhJq2KJSSyM4ohKbRhFVjIFqY10rJEgmhgjMecoFphjGylSBbu_s1citSJtt7rnlxfpj7DVU20t-_31YZjAKCHfD9Jkqg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>线粒体障碍在非酒精性脂肪性肝炎中的作用机制</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>蔡恬莹 ; 黄美州 ; 陈浩 ; 钱保林 ; 付文广</creator><creatorcontrib>蔡恬莹 ; 黄美州 ; 陈浩 ; 钱保林 ; 付文广</creatorcontrib><description>R575.5; 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病.研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用.以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗.</description><identifier>ISSN: 1001-5256</identifier><identifier>DOI: 10.3969/j.issn.1001-5256.2021.08.045</identifier><language>chi</language><publisher>西南医科大学附属医院肝胆外科,四川泸州646000</publisher><ispartof>临床肝胆病杂志, 2021-08, Vol.37 (8), p.1953-1956</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/lcgdbzz/lcgdbzz.jpg</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>蔡恬莹</creatorcontrib><creatorcontrib>黄美州</creatorcontrib><creatorcontrib>陈浩</creatorcontrib><creatorcontrib>钱保林</creatorcontrib><creatorcontrib>付文广</creatorcontrib><title>线粒体障碍在非酒精性脂肪性肝炎中的作用机制</title><title>临床肝胆病杂志</title><description>R575.5; 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病.研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用.以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗.</description><issn>1001-5256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9j7tKA0EARadQMMT8hYXNrvPYmd2pRIIvCNikD_MMCWEFBxFSyRLBRotoFTYWNgbBJoVIIPozm0z2LzQoVvdyinu4AOwgGBLO-F437DiXhghCFFBMWYghRiFMQhjRDVD551ug5lxHQooI4xFlFbDvZ19-OizmD-Uo9893i3xSjp_Km6Gffi6vX1aDbJW9rks29tl98fHmR4NinvvHyTKfLW7ft8GmFT1nan9ZBc2jw2b9JGicHZ_WDxqBQ5AkgWYICoQFNVhJq2KJSSyM4ohKbRhFVjIFqY10rJEgmhgjMecoFphjGylSBbu_s1citSJtt7rnlxfpj7DVU20t-_31YZjAKCHfD9Jkqg</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>蔡恬莹</creator><creator>黄美州</creator><creator>陈浩</creator><creator>钱保林</creator><creator>付文广</creator><general>西南医科大学附属医院肝胆外科,四川泸州646000</general><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20210801</creationdate><title>线粒体障碍在非酒精性脂肪性肝炎中的作用机制</title><author>蔡恬莹 ; 黄美州 ; 陈浩 ; 钱保林 ; 付文广</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s1038-d610a12a5e2cbfc7b237aec915bde651fb6c05f4d7d1a3d3eeb29917a292f4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>蔡恬莹</creatorcontrib><creatorcontrib>黄美州</creatorcontrib><creatorcontrib>陈浩</creatorcontrib><creatorcontrib>钱保林</creatorcontrib><creatorcontrib>付文广</creatorcontrib><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>临床肝胆病杂志</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>蔡恬莹</au><au>黄美州</au><au>陈浩</au><au>钱保林</au><au>付文广</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>线粒体障碍在非酒精性脂肪性肝炎中的作用机制</atitle><jtitle>临床肝胆病杂志</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>37</volume><issue>8</issue><spage>1953</spage><epage>1956</epage><pages>1953-1956</pages><issn>1001-5256</issn><abstract>R575.5; 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病.研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用.以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗.</abstract><pub>西南医科大学附属医院肝胆外科,四川泸州646000</pub><doi>10.3969/j.issn.1001-5256.2021.08.045</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1001-5256 |
| ispartof | 临床肝胆病杂志, 2021-08, Vol.37 (8), p.1953-1956 |
| issn | 1001-5256 |
| language | chi |
| recordid | cdi_wanfang_journals_lcgdbzz202108048 |
| source | EZB-FREE-00999 freely available EZB journals |
| title | 线粒体障碍在非酒精性脂肪性肝炎中的作用机制 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T19%3A46%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%E7%BA%BF%E7%B2%92%E4%BD%93%E9%9A%9C%E7%A2%8D%E5%9C%A8%E9%9D%9E%E9%85%92%E7%B2%BE%E6%80%A7%E8%84%82%E8%82%AA%E6%80%A7%E8%82%9D%E7%82%8E%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6&rft.jtitle=%E4%B8%B4%E5%BA%8A%E8%82%9D%E8%83%86%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E8%94%A1%E6%81%AC%E8%8E%B9&rft.date=2021-08-01&rft.volume=37&rft.issue=8&rft.spage=1953&rft.epage=1956&rft.pages=1953-1956&rft.issn=1001-5256&rft_id=info:doi/10.3969/j.issn.1001-5256.2021.08.045&rft_dat=%3Cwanfang_jour%3Elcgdbzz202108048%3C/wanfang_jour%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_wanfj_id=lcgdbzz202108048&rfr_iscdi=true |